DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and cpr-8

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_503384.1	Gene:	cpr-8 / 178613	WormBaseID:	WBGene00021070	Length:	335	Species:	Caenorhabditis elegans

Alignment Length:	329	Identity:	137/329 - (41%)
Similarity:	186/329 - (56%)	Gaps:	18/329 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GEPSLLSDEFIEVVRSKAKTWTVGRNFDASVTEGHIRRLMGVHPDAHKFALPDKREVLGDLYVNS 83
            |.|....|..|..|.|:..|||.|  ..|......::.|:   .||.....  |.:..|....||
Worm    17 GVPPSEIDRIIHYVNSQKTTWTAG--IPALSRNSMLKTLV---TDAATIGF--KIQNFGVSQANS 74

  Fly    84 VDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSC 148
              :|...||:|::||.|.:|.:|.|...|.:.|||.|.|:||||:||:|||..|...||::|:||
Worm    75 --DLSPSFDARERWPECMSIPQINDISECKTSWAFAAAESMSDRLCINSGGFKNTILSAEELLSC 137

  Fly   149 C---HTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHV-NGTRPPCAH-GG 208
            |   .:||.||.||.|..||.|..:.||.:||.|.|..||:||.|.||...| |.|.|.|.: ..
Worm   138 CTGMFSCGEGCEGGNPFKAWQYIQKHGIPTGGSYESQFGCKPYSIPPCGKTVGNVTYPACTNTTS 202

  Fly   209 RTPKCSHVCQS--GYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDG 271
            .||.|...|.|  ||.:|..||:|:|.....:..:..|||.::|.|||::..|.||:|.:.|..|
Worm   203 PTPSCEKKCTSRIGYPIDIDKDRHYGVSVDQLPNSQIEIQSDVMLNGPIQATFEVYDDFLQYTTG 267

  Fly   272 VYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIESSISAG 336
            :|.|..|.:.|..::||:|||||  :.:||||..|||...||::|.||:|||.:.||:||:..:|
Worm   268 IYVHLTGNKQGHLSVRIIGWGVW--QGVPYWLCANSWGRQWGENGTFRVLRGTNECGLESNCVSG 330

  Fly   337 LPKL 340
            :|||
Worm   331 MPKL 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	10/39 (26%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	114/254 (45%)
cpr-8	NP_503384.1	Propeptide_C1	24..>40	CDD:369701	7/15 (47%)
cpr-8	NP_503384.1	Peptidase_C1A_CathepsinB	79..330	CDD:239111	114/252 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D439739at33208
OrthoFinder	1	1.000	-	-		FOG0001215
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101151
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.790