DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and cpr-5

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_503383.1	Gene:	cpr-5 / 178612	WormBaseID:	WBGene00000785	Length:	344	Species:	Caenorhabditis elegans

Alignment Length:	349	Identity:	168/349 - (48%)
Similarity:	214/349 - (61%)	Gaps:	21/349 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLLLLVATAASVAALTSGE-PSLLSDEFIEVVRSKAKTWTVGRNFDASVTEGHIRRLMGVHPDA 64
            ::.:||||.|::|......| |:|.....|:.|.|..|.||.|.  .....|...::||.|
Worm     4 LSAILLVAAASAVVIPGHREAPALTGQALIDYVNSAQKLWTAGH--QVIPKEKITKKLMDV---- 62

  Fly    65 HKFALPDKREVLGDLYVNSV-DELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRV 128
             |:.:|.|.|   |:....| |.:|:.||:|.|||||.:|..||||..|||||||.|.||:|||.
Worm    63 -KYLVPHKDE---DIVATEVSDAIPDHFDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRT 123

  Fly   129 CIHSGGKVNFHFSADDLVSCC---HTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEI 190
            ||.|.|.||...|::||:|||   .:||.||.||:|..||.:|.:.|:|:||.|.:..||:||.|
Worm   124 CIASNGAVNTLLSSEDLLSCCTGMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSI 188

  Fly   191 SPCEHHVNGTR-PPCAHGGR-TPKCSHVCQS--GYTVDYAKDKHFGSKSYSVRRNVREIQEEIMT 251
            :||...|||.: |.|..... ||||...|.|  .|...|.:||||||.:|:|.:.|.:||.||:|
Worm   189 APCGETVNGVKWPACPEDTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILT 253

  Fly   252 NGPVEGAFTVYEDLILYKDGVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHG 316
            |||:|.|||||||...|..|||.|..|..|||||::||||||  :...||||:.||||..||:.|
Worm   254 NGPIEVAFTVYEDFYQYTTGVYVHTAGASLGGHAVKILGWGV--DNGTPYWLVANSWNVAWGEKG 316

  Fly   317 FFRILRGQDHCGIESSISAGLPKL 340
            :|||:||.:.||||.|..||:|.|
Worm   317 YFRIIRGLNECGIEHSAVAGIPDL 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	11/39 (28%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	137/254 (54%)
cpr-5	NP_503383.1	Propeptide_C1	30..63	CDD:285358	11/39 (28%)
cpr-5	NP_503383.1	Peptidase_C1A_CathepsinB	83..336	CDD:239111	137/254 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161096
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2776
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D439739at33208
OrthoFinder	1	1.000	-	-		FOG0001215
OrthoInspector	1	1.000	-	-		otm14118
orthoMCL	1	0.900	-	-		OOG6_101151
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2465
SonicParanoid	1	1.000	-	-		X1059
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.700