DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and cpz-1

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_491023.2	Gene:	cpz-1 / 171829	WormBaseID:	WBGene00000788	Length:	306	Species:	Caenorhabditis elegans

Alignment Length:	257	Identity:	70/257 - (27%)
Similarity:	106/257 - (41%)	Gaps:	52/257 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 EEFDSRKQWPNCPTIGEIRDQGS---------------CGSCWAFGAVEAMSDRVCI-HSGGKVN 137
            |:|||.    :.|...:.||...               |||||||||..|::||:.| .......
Worm    58 EDFDSE----DLPKTWDWRDANGINYASADRNQHIPQYCGSCWAFGATSALADRINIKRKNAWPQ 118

  Fly   138 FHFSADDLVSC--CHTCGFGCNGGFPGAAWSYWTRKGI--VSGGPYGSNQG-CRPYEISPCEHHV 197
            .:.|..:::.|  ..||   ..||.||..:.|....||  .:...|.:..| |.||  :.|
Worm   119 AYLSVQEVIDCSGAGTC---VMGGEPGGVYKYAHEHGIPHETCNNYQARDGKCDPY--NRC---- 174

  Fly   198 NGTRPPCAHGGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVY 262
             |:   |..|    :|..:  ..||:       :....|.......:::.||...||:.......
Worm   175 -GS---CWPG----ECFSI--KNYTL-------YKVSEYGTVHGYEKMKAEIYHKGPIACGIAAT 222

  Fly   263 EDLILYKDGVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQ 324
            :....|..|:|:....::: .|.|.:.||||..|..:.||:..|||...||:||:|:|:..|
Worm   223 KAFETYAGGIYKEVTDEDI-DHIISVHGWGVDHESGVEYWIGRNSWGEPWGEHGWFKIVTSQ 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	70/257 (27%)
cpz-1	NP_491023.2	Peptidase_C1A_CathepsinX	65..305	CDD:239149	66/246 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810