Protein Alignment CtsB1 and CTSW

DIOPT Version :9

• Sequence 1: NP_001259536.2
• Gene: CtsB1 / 32341
• FlyBaseID: FBgn0030521
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_001326.3
• Gene: CTSW / 1521
• HGNCID: 2546
• Length: 376
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 87/401 - (21%)
• Similarity: 134/401 - (33%)
• Gaps: 139/401 - (34%)

  Fly    10 AASVAALTSG------------EPSLLSDEFIEVVRSKAKTWTVGRNFDASVTEGHIRRLMGVHP 62
            |..||.|..|            :|..|.:.|        |.:.:..|......|.|..||
Human    12 ALLVAGLAQGIRGPLRAQDLGPQPLELKEAF--------KLFQIQFNRSYLSPEEHAHRL----- 63

  Fly    63 D--AHKFALPDK--------------------REVLGDLY-----VNSVDELPEEFDSRKQWPNC 100
            |  ||..|...:                    .|..|.||     ...|..:..|..|.:...:.
Human    64 DIFAHNLAQAQRLQEEDLGTAEFGVTPFSDLTEEEFGQLYGYRRAAGGVPSMGREIRSEEPEESV 128

  Fly   101 P----------TIGEIRDQGSCGSCWAF---GAVEAMSDRVCIHSGGKVNF----HFSADDLVSC 148
            |          .|..|:||.:|..|||.   |.:|.:         .:::|    ..|..:|:.
Human   129 PFSCDWRKVASAISPIKDQKNCNCCWAMAAAGNIETL---------WRISFWDFVDVSVQELLD- 183

  Fly   149 CHTCGFGCNGGFPGAAWSYW----TRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGR 209
            |..||.||:|||   .|..:    ...|:.|...|......|.:...|.::.
Human   184 CGRCGDGCHGGF---VWDAFITVLNNSGLASEKDYPFQGKVRAHRCHPKKYQ------------- 232

  Fly   210 TPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDGVYQ 274
                        .|.:.:|      ...::.|...|.:.:.|.||:.....: :.|.||:.||.:
Human   233 ------------KVAWIQD------FIMLQNNEHRIAQYLATYGPITVTINM-KPLQLYRKGVIK 278

  Fly   275 HEH---GKELGGHAIRILGW-------GVWGE-----------EKIPYWLIGNSWNTDWGDHGFF 318
            ...   ..:|..|::.::|:       |:|.|           ...|||::.|||...||:.|:|
Human   279 ATPTTCDPQLVDHSVLLVGFGSVKSEEGIWAETVSSQSQPQPPHPTPYWILKNSWGAQWGEKGYF 343

  Fly   319 RILRGQDHCGI 329
            |:.||.:.|||
Human   344 RLHRGSNTCGI 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	9/41 (22%)
		Peptidase_C1A_CathepsinB	88..336	CDD:239111	64/284 (23%)
CTSW	NP_001326.3	Inhibitor_I29	42..98	CDD:214853	11/68 (16%)
		Peptidase_C1A	129..358	CDD:239068	62/271 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149673
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740