Protein Alignment CtsB1 and CTSS

DIOPT Version :9

• Sequence 1: NP_001259536.2
• Gene: CtsB1 / 32341
• FlyBaseID: FBgn0030521
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_004070.3
• Gene: CTSS / 1520
• HGNCID: 2545
• Length: 331
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 88/305 - (28%)
• Similarity: 138/305 - (45%)
• Gaps: 63/305 - (20%)

  Fly    38 TWTVGRNFDASVTEGHIRRLMGVHPDAHKFALPD--KREVLGDLYVNSVDELPEEFDSRKQWPNC 100
            ::.:|.|....:|...:..||.      ...:|.  :|.:......|.:  ||:..|.|::  .|
Human    72 SYDLGMNHLGDMTSEEVMSLMS------SLRVPSQWQRNITYKSNPNRI--LPDSVDWREK--GC 126

  Fly   101 PTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCGF---GCNGGFPG 162
            .|  |::.|||||:||||.||.|:..::.:.:|..|:  .||.:||. |.|..:   ||||||..
Human   127 VT--EVKYQGSCGACWAFSAVGALEAQLKLKTGKLVS--LSAQNLVD-CSTEKYGNKGCNGGFMT 186

  Fly   163 AAWSY-WTRKGIVSGGPYGSNQGCRPYEI--SPCEHHVNGTRPPCAHGGRTPKCSHVCQSGYTVD 224
            .|:.| ...|||.|...|       ||:.  ..|::........|              |.||
Human   187 TAFQYIIDNKGIDSDASY-------PYKAMDQKCQYDSKYRAATC--------------SKYT-- 228

  Fly   225 YAKDKHFGSKSYSVRRNVREIQEEIMTNGPVE-GAFTVYEDLILYKDGVYQHEHGKELGGHAIRI 288
               :..:|      |.:|  ::|.:...|||. |....:....||:.|||......:...|.:.:
Human   229 ---ELPYG------REDV--LKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLV 282

  Fly   289 LGWG-VWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQ-DHCGIES 331
            :|:| :.|:|   |||:.|||..::|:.|:.|:.|.: :||||.|
Human   283 VGYGDLNGKE---YWLVKNSWGHNFGEEGYIRMARNKGNHCGIAS 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	5/25 (20%)
		Peptidase_C1A_CathepsinB	88..336	CDD:239111	79/253 (31%)
CTSS	NP_004070.3	PTZ00203	5..326	CDD:185513	88/305 (29%)
		Inhibitor_I29	28..87	CDD:214853	3/14 (21%)
		Peptidase_C1	115..329	CDD:278538	80/254 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820