DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CtsB1 and CTSO

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001325.1	Gene:	CTSO / 1519	HGNCID:	2542	Length:	321	Species:	Homo sapiens

Alignment Length:	257	Identity:	71/257 - (27%)
Similarity:	109/257 - (42%)	Gaps:	54/257 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHT 151
            ||..||    |.:...:.::|:|..||.||||..|.|:.....|.  ||.....|...::.|.:.
Human   108 LPLRFD----WRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIK--GKPLEDLSVQQVIDCSYN 166

  Fly   152 CGFGCNGGFPGAAWSYWTRKGIV-----SGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTP 211
             .:|||||....|.: |..|..|     |..|:.:..|.       | |:.:|
Human   167 -NYGCNGGSTLNALN-WLNKMQVKLVKDSEYPFKAQNGL-------C-HYFSG------------ 209

  Fly   212 KCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKD---GVY 273
              ||   ||:::.       |..:|.......|:.:.::|.||:    .|..|.:.::|   |:.
Human   210 --SH---SGFSIK-------GYSAYDFSDQEDEMAKALLTFGPL----VVIVDAVSWQDYLGGII 258

  Fly   274 QHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILRGQDHCGIESSISA 335
            ||........||:.|.|:...|  ..|||::.|||.:.||..|:..:..|.:.|||..|:|:
Human   259 QHHCSSGEANHAVLITGFDKTG--STPYWIVRNSWGSSWGVDGYAHVKMGSNVCGIADSVSS 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	70/256 (27%)
CTSO	NP_001325.1	Peptidase_C1A	109..319	CDD:239068	70/256 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810