Protein Alignment CtsB1 and CTSL

DIOPT Version :9

• Sequence 1: NP_001259536.2
• Gene: CtsB1 / 32341
• FlyBaseID: FBgn0030521
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_001244900.1
• Gene: CTSL / 1514
• HGNCID: 2537
• Length: 333
• Species: Homo sapiens
• Alignment Length: 378
• Identity: 91/378 - (24%)
• Similarity: 148/378 - (39%)
• Gaps: 100/378 - (26%)

  Fly     4 LLLVATAASVAALTSGEPSLLSDEFIEVVRSKAKTWTVGRNFDASVTEGHIRRLMGVHPDAHKFA 68
            |:|.|....:|:.|     |..|..:|...:|   |....|           ||.|::.:..:.|
Human     5 LILAAFCLGIASAT-----LTFDHSLEAQWTK---WKAMHN-----------RLYGMNEEGWRRA 50

  Fly    69 LPDK------------RE----------VLGDLYVNSVDELPEEFDSRK---------------- 95
            :.:|            ||          ..||:......::...|.:||
Human    51 VWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAP 115

  Fly    96 ---QWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCG-FGC 156
               .|.....:..:::||.|||||||.|..|:..::...:|..::  .|..:||.|....| .||
Human   116 RSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLIS--LSEQNLVDCSGPQGNEGC 178

  Fly   157 NGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGGRTPKCSHVCQSGY 221
            |||....|:.|     :...|...|.:. .|||         .|...|.:   .||.|....:|:
Human   179 NGGLMDYAFQY-----VQDNGGLDSEES-YPYE---------ATEESCKY---NPKYSVANDTGF 225

  Fly   222 TVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTV-YEDLILYKDGVY-QHEHGKELGGH 284
             ||..|.:             :.:.:.:.|.||:..|... :|..:.||:|:| :.:...|...|
Human   226 -VDIPKQE-------------KALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDH 276

  Fly   285 AIRILGWGVWGEE--KIPYWLIGNSWNTDWGDHGFFRILRG-QDHCGIESSIS 334
            .:.::|:|....|  ...|||:.|||..:||..|:.::.:. ::||||.|:.|
Human   277 GVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAAS 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	8/39 (21%)
		Peptidase_C1A_CathepsinB	88..336	CDD:239111	71/272 (26%)
CTSL	NP_001244900.1	Inhibitor_I29	29..87	CDD:214853	12/71 (17%)
		Peptidase_C1	114..332	CDD:395062	68/250 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149676
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750