Protein Alignment CtsB1 and CTSH

DIOPT Version :9

• Sequence 1: NP_001259536.2
• Gene: CtsB1 / 32341
• FlyBaseID: FBgn0030521
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_004381.2
• Gene: CTSH / 1512
• HGNCID: 2535
• Length: 335
• Species: Homo sapiens
• Alignment Length: 336
• Identity: 86/336 - (25%)
• Similarity: 137/336 - (40%)
• Gaps: 72/336 - (21%)

  Fly    25 SDEFIEVVRSKAKTWTVGRNFDASVTEGHIRRL-------MGVHPDAHKF--ALPDKREVLGDLY 80
            ::|:...:::.|..|   |..:|.....|..::       |......||:  :.|.........|
Human    48 TEEYHHRLQTFASNW---RKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNY 109

  Fly    81 VNSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDL 145
            :......|...|.||:.   ..:..:::||:|||||.|....|:...:.|.:|..::  .:...|
Human   110 LRGTGPYPPSVDWRKKG---NFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLS--LAEQQL 169

  Fly   146 VSCCHTC-GFGCNGGFPGAAWSY-WTRKGIVSGGPYGSNQGCRPYEISPCEHHVNGTRPPCAHGG 208
            |.|.... ..||.||.|..|:.| ...|||:....|       ||:                  |
Human   170 VDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTY-------PYQ------------------G 209

  Fly   209 RTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTN-----GPVEGAFTVYEDLILY 268
            :...|..  |.|..:.:.||.          .|:....||.|..     .||..||.|.:|.::|
Human   210 KDGYCKF--QPGKAIGFVKDV----------ANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMY 262

  Fly   269 KDGVYQ----HEHGKELGGHAIRILGWGVWGEEK--IPYWLIGNSWNTDWGDHGFFRILRGQDHC 327
            :.|:|.    |:...:: .||:..:|:|    ||  ||||::.|||...||.:|:|.|.||::.|
Human   263 RTGIYSSTSCHKTPDKV-NHAVLAVGYG----EKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMC 322

  Fly   328 GIESSISAGLP 338
            |:.:..|..:|
Human   323 GLAACASYPIP 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	7/45 (16%)
		Peptidase_C1A_CathepsinB	88..336	CDD:239111	74/260 (28%)
CTSH	NP_004381.2	Inhibitor_I29	35..90	CDD:285458	7/44 (16%)
		Peptidase_C1	117..332	CDD:278538	74/261 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820