DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and Ctsb

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_031824.1	Gene:	Ctsb / 13030	MGIID:	88561	Length:	339	Species:	Mus musculus

Alignment Length:	343	Identity:	194/343 - (56%)
Similarity:	244/343 - (71%)	Gaps:	20/343 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLLLLVATAASVAALTSG--EPSL--LSDEFIEVVRSKAKTWTVGRNFDASVTEGHIRRLMGVHP 62
            :|:||    :.:.||||.  :||.  |||:.|..:..:..||..|||| .:|...::::|.|...
Mouse     4 SLILL----SCLLALTSAHDKPSFHPLSDDLINYINKQNTTWQAGRNF-YNVDISYLKKLCGTVL 63

  Fly    63 DAHKFALPDKREVLGDLYVNSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDR 127
            ...|  ||.:.....|:      :|||.||:|:||.||||||:||||||||||||||||||:|||
Mouse    64 GGPK--LPGRVAFGEDI------DLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDR 120

  Fly   128 VCIHSGGKVNFHFSADDLVSCCH-TCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEIS 191
            .|||:.|:||...||:||::||. .||.|||||:|..|||:||:||:||||.|.|:.||.||.|.
Mouse   121 TCIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIP 185

  Fly   192 PCEHHVNGTRPPCAHGGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVE 256
            ||||||||:||||...|.||:|:..|::||:..|.:|||||..||||..:|:||..||..|||||
Mouse   186 PCEHHVNGSRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVE 250

  Fly   257 GAFTVYEDLILYKDGVYQHEHGKELGGHAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRIL 321
            |||||:.|.:.||.|||:||.|..:||||||||||||  |..:||||..||||.||||:|||:||
Mouse   251 GAFTVFSDFLTYKSGVYKHEAGDMMGGHAIRILGWGV--ENGVPYWLAANSWNLDWGDNGFFKIL 313

  Fly   322 RGQDHCGIESSISAGLPK 339
            ||::||||||.|.||:|:
Mouse   314 RGENHCGIESEIVAGIPR 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	13/39 (33%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	164/248 (66%)
Ctsb	NP_031824.1	Propeptide_C1	26..65	CDD:285358	13/39 (33%)
Ctsb	NP_031824.1	Peptidase_C1A_CathepsinB	81..328	CDD:239111	164/248 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	380	1.000	Domainoid score	I844
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37550
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1904
Isobase	1	0.950	-	0	Normalized mean entropy	S2776
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001215
OrthoInspector	1	1.000	-	-		oto94309
orthoMCL	1	0.900	-	-		OOG6_101151
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2465
SonicParanoid	1	1.000	-	-		X1059
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810