DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtsB1 and AgaP_AGAP007684

DIOPT Version :9

Sequence 1:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_001687862.1	Gene:	AgaP_AGAP007684 / 1269545	VectorBaseID:	AGAP007684	Length:	463	Species:	Anopheles gambiae

Alignment Length:	346	Identity:	101/346 - (29%)
Similarity:	148/346 - (42%)	Gaps:	60/346 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ALTSGEPSLLSDEFI-----EVVRS---KAKTWTV--GRNFDASVTEGHIRRLMGVHPDAHKFAL 69
            ::|..|...|:|:.:     .:.||   ||..::.  |..:|    ||.:.||....|   :|.:
Mosquito   117 SVTCTEDVCLADDDLLRQLHHLERSIGWKATNYSEWWGHKYD----EGKVLRLGTFQP---RFRV 174

  Fly    70 PDKREVLGDLYVNSVDELPEEFDSRKQWPNCPTIGEIRDQGSCGSCWAFGAVEAMSDRVCIHSGG 134
            ...:.:     .|....||..||:.:.|..  .:.|.||||.|||.|||......|||..|.|.|
Mosquito   175 KAMKRL-----SNKGGHLPTRFDASEHWTG--LVAEARDQGWCGSSWAFSTATMASDRFAILSKG 232

  Fly   135 KVNFHFSADDLVSCCHTCGFGCNGGFPGAAWSYWTRKGIVSGGPYGSNQGCRPYEISP--CEHHV 197
            :.....:...:::|... ..||:||....||.|..|.|:|       |:.|.||..:.  |:...
Mosquito   233 REMVQLAPQQMLACVRR-QQGCSGGHLDTAWQYLRRTGVV-------NEECYPYIAAQNVCKISN 289

  Fly   198 NGTRPPCAHGGRTPKCSHVCQSGYTVDYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVY 262
            :.|.       .|..|....:...|:.|.....|.      ..|..:|..||...|.|:....||
Mosquito   290 DDTL-------ITANCELPVKVNRTLMYKMGPAFS------LNNETDIMAEIKDRGTVQAIMRVY 341

  Fly   263 EDLILYKDGVYQHEHG-----KELGGHAIRILGWGVWGEEK-----IPYWLIGNSWNTDWGDHGF 317
            .|...|:.|:|:|...     :....|::|::|   ||||:     :.||:..|||...||::|.
Mosquito   342 RDFFSYRSGIYRHSAAATPAEERSAYHSVRLIG---WGEERVGYDVVKYWIAINSWGQWWGENGR 403

  Fly   318 FRILRGQDHCGIESSISAGLP 338
            ||||||.:.|.|||.:.|..|
Mosquito   404 FRILRGSNECDIESYVLASNP 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358	13/49 (27%)
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	81/259 (31%)
AgaP_AGAP007684	XP_001687862.1	Somatomedin_B	37..78	CDD:279385
		VWC	89..>136	CDD:302663	4/18 (22%)
		Peptidase_C1A_CathepsinB	188..421	CDD:239111	81/258 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910