Protein Alignment rdgB and LPIN2

DIOPT Version :10

• Sequence 1: NP_001259535.1
• Gene: rdgB / 32340
• FlyBaseID: FBgn0003218
• Length: 1297
• Species: Drosophila melanogaster
• Sequence 2: XP_005258234.1
• Gene: LPIN2 / 9663
• HGNCID: 14450
• Length: 933
• Species: Homo sapiens
• Alignment Length: 1027
• Identity: 177/1027 - (17%)
• Similarity: 298/1027 - (29%)
• Gaps: 396/1027 - (38%)

  Fly   347 QGGSAQ--------------RSRSQSIQMAQKGKFGSKGALHSPVG-SAHSFDLQSKKPHAKTAP 396
            |.||.|              ||:.:.|.:...   ||...||..:| :..:|.::..:...:..|
Human    76 QDGSYQCSPFHVRFGKLGVLRSKEKVIDIEIN---GSAVDLHMKLGDNGEAFFVEETEEEYEKLP 137

  Fly   397 RRHVANWRMERLEVDSKSNSDEEFFDCLDTNETNSLAKWSSLELLGEGDDSPPPHGG-------- 453
             .::|.         |...::::||..:||            .|:..|.|..|....
Human   138 -AYLAT---------SPIPTEDQFFKDIDT------------PLVKSGGDETPSQSSDISHVLET 180

  Fly   454 -----PSSAASVGGRGNSRQEDSIFNQDFLMRVASERGNKRQLRSSASVDRSHD----------- 502
                 |||......|....::||               .|.:..:||:.:.:.|
Human   181 ETIFTPSSVKKKKRRRKKYKQDS---------------KKEEQAASAAAEDTCDVGVSSDDDKGA 230

  Fly   503 ----SSPPGSPSTPSCPTTILILVVHAG----------SVLDAASELTA-KKSDVTTFRGSFEAV 552
                .|...|.....|...:|.   |:|          |.|:.....|| .|||........|::
Human   231 QAARGSSNASLKEEECKEPLLF---HSGDHYPLSDGDWSPLETTYPQTACPKSDSELEVKPAESL 292

  Fly   553 MR------------------------QHYPSLLT-----HVTIKMVPC---------------PS 573
            :|                        .|:|...|     :...:::|.               .:
Human   293 LRSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRVIPSEDNLISEVEKDASMEDT 357

  Fly   574 ICT--------------DALGILSSLSP----------YSFDASPSAADIPNIADVPIGAIPLLS 614
            :||              |...:...|.|          ...|..|:||    :|:.|..:.|...
Human   358 VCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLDADHLPNAA----LAEAPSESKPAAK 418

  Fly   615 VASPEFHETVNKTV--AAANIVYHEFLKSEEGHGFSGQIVMLGDSMGSLLAYEALCRSNGSQPG- 676
            |.||...:.|:|..  ...:.:|.:.||     |...::..|            ....:.|:||
Human   419 VDSPSKKKGVHKRSQHQGPDDIYLDDLK-----GLEPEVAAL------------YFPKSESEPGS 466

  Fly   677 -------TASGASN--SGGDAATNINTHNPLSPRNSRLDDDERFIEADLDAKRLLVAPSPRRRRS 732
                   |.||:.:  |.|.||.:..|              |...::.:|...:.::..     .
Human   467 RQWPESDTLSGSQSPQSVGSAAADSGT--------------ECLSDSAMDLPDVTLSLC-----G 512

  Fly   733 SSSSDSRATKLDFEVCDFFMFGSPLSVVLAARKLHDAKAALPRPN-CHQVYNLFHPTDPIASRLE 796
            ..|.:...:|..|           :..::...:..:....:..|| ..::||.::
Human   513 GLSENGEISKEKF-----------MEHIITYHEFAENPGLIDNPNLVIRIYNRYY---------- 556

  Fly   797 PLLSARFSILAPVNVPRYAKYPLGNGQPLHLLEVIQSHPQHFNDGNNLLAGRRLSDASMQSTISG 861
                 .:::.||:               :..|:|.|               :.|..|:::|.:..
Human   557 -----NWALAAPM---------------ILSLQVFQ---------------KSLPKATVESWVKD 586

  Fly   862 LIENVSLSTIHALQNKWW-GTKRLDYALYCPEGLSNFPAHALPHLFHASYWESPDVIAFILRQIG 925
            .:...|        .:|| ..||.......||.                             :.|
Human   587 KMPKKS--------GRWWFWRKRESMTKQLPES-----------------------------KEG 614

  Fly   926 KFEGIPFVGSNDDKDNASFHPGQPREKWIKKRTSVKLKNVAANHRANDVIVQEGREQRLNARFMY 990
            |.|..|          ||..|...:|.            ..|....||....|| .|.|......
Human   615 KSEAPP----------ASDLPSSSKEP------------AGARPAENDSSSDEG-SQELEESITV 656

  Fly   991 GPLDMITL-HGEKVDVHIMKDPPAGEWTFLSTEVTDKNGRISYSIPDQVSLGYG----IYPVKMV 1050
            .|:....| ||                   ||....|:.|:|.....::.|..|    ::.:...
Human   657 DPIPTEPLSHG-------------------STTSYKKSLRLSSDQIAKLKLHDGPNDVVFSITTQ 702

  Fly  1051 VRGDHTSVDCYMAVVPPL----TECVVFSIDGSFTAS------MSVTGRDPKVRAGAVDVCRHWQ 1105
            .:|     .|..|....|    .:.::..|||:.|.|      :...|:| ....|...:.....
Human   703 YQG-----TCRCAGTIYLWNWNDKIIISDIDGTITKSDALGQILPQLGKD-WTHQGIAKLYHSIN 761

  Fly  1106 ELGYLLIYIT----GRPDMQQQRVVSWLSQHN--FPHGLISFA----------DGLSTDPLGHKT 1154
            |.||..:|.:    |..|| .:..:.|::...  .|.|.:..:          :.:...|...|.
Human   762 ENGYKFLYCSARAIGMADM-TRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIEKKPEKFKI 825

  Fly  1155 AYLN---NLVQNHGISITAAYGS-SKDISVYTNVGMRTDQIFIVGKVGKKLQ 1202
            ..||   ||.........||:|: ..|:..||.||:...:||.|...|:.:|
Human   826 ECLNDIKNLFAPSKQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQ 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898
		DDHD	743..924	CDD:460725	20/182 (11%)
		LNS2	1072..1203	CDD:197870	37/157 (24%)
LPIN2	XP_005258234.1	Lipin_N	38..144	CDD:461356	15/80 (19%)
		Lipin_mid	506..598	CDD:465292	18/160 (11%)
		LNS2	674..899	CDD:462403	46/211 (22%)
		WRNPLPNID	912..>930	CDD:464448