DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgB and PITPNM1

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	NP_004901.2	Gene:	PITPNM1 / 9600	HGNCID:	9003	Length:	1244	Species:	Homo sapiens

Alignment Length:	1345	Identity:	582/1345 - (43%)
Similarity:	789/1345 - (58%)	Gaps:	191/1345 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLIKEYRIPLPLTVEEYRIAQLYMIAKKSREESHGEGSGVEIIINEPYKDGPGGNGQYTKKIYHV 65
            ||||||.|.||::::||::||||||.|||||||.||||||||:.|.||.|||||:||||.|:|||
Human     1 MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGSGQYTHKVYHV 65

  Fly    66 GNHLPGWIKSLLPKSALTVEEEAWNAYPYTRTRYTCPFVEKFSLDIETYYYPDNGYQDNVFQLSG 130
            |:|:|||.::||||:||.||||:||||||||||||||||||||::|||||.||.|.|.|||.|||
Human    66 GSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSG 130

  Fly   131 SDLRNRIVDVIDIVKDQLWGGDYVKEEDPKHFVSDKTGRGPLAEDWLEEYWREVKGKKQPTPRNM 195
            ::.|.||:|.||||:|.:..|:|..||||:.:.|.|||||||::||       .:...|..|
Human   131 AERRQRILDTIDIVRDAVAPGEYKAEEDPRLYHSVKTGRGPLSDDW-------ARTAAQTGP--- 185

  Fly   196 SLMTAYKICRVEFRYWGMQTKLEKFIHDVALRKMMLRAHRQAWAWQDEWFGLTIEDIRELERQTQ 260
             ||.|||:|:|||||||||.|:|:|||||.||::|||||||||.|||||..|::.|||.||.:|.
Human   186 -LMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWTELSMADIRALEEETA 249

  Fly   261 LALAKKMGGGEECSDDSVSEP--YVST-AATAASTTGSERKKSAPAVPPIVTQQPPSAEASSDEE 322
            ..||::|......|:.|.::|  ..|| |.:|||.||:          |...:.||..:||.|.
Human   250 RMLAQRMAKCNTGSEGSEAQPPGKPSTEARSAASNTGT----------PDGPEAPPGPDASPDA- 303

  Fly   323 GEEEEDDDEDENDAIGTGVDLSANQGGSAQRSRSQSIQMAQKGKFGSKGALHSPVGSAHSFDLQS 387
                                    ..|....|.|:|...:|.|     ||: ||
Human   304 ------------------------SFGKQWSSSSRSSYSSQHG-----GAV-SP----------- 327

  Fly   388 KKPHAKTAPRRHVANWRMERLEVDSKSNSDEEFFDC----LDTNET--NSLAKWSSLELLG---- 442
                      :.::.|||:.:..||:::|:|||||.    .|:.|.  ..:.||:|.:.:.
Human   328 ----------QSLSEWRMQNIARDSENSSEEEFFDAHEGFSDSEEVFPKEMTKWNSNDFIDAFAS 382

  Fly   443 --EGDDSPPPHGGPSSAASVGGRGNSRQEDSIFNQDFLMRVASERGNKRQLRSSASVDRSHDSSP 505
              |.:.:|.|  |..:|..:        ||                ..:..|.|..:|.:
Human   383 PVEAEGTPEP--GAEAAKGI--------ED----------------GAQAPRDSEGLDGA----- 416

  Fly   506 PGSPSTPSCPTTILILVVHAGSVLDAA-SELTAKKSDVTTFRGSFEAVMRQHYPSLLTHVTIKMV 569
             |.....:|....|.|::|:|::||:. .:..:|::||.|...:||||.|.|:|..|.||.:::|
Human   417 -GELGAEACAVHALFLILHSGNILDSGPGDANSKQADVQTLSSAFEAVTRIHFPEALGHVALRLV 480

  Fly   570 PCPSICTDALGILSSLSPYSFDASPSAADIPNIADVPIGAIPLLSVASPEFHETVNKTVAAANIV 634
            |||.||..|..::|:|||||.|....:....:|   |:.|:|||:.:|..:...|...:|..|..
Human   481 PCPPICAAAYALVSNLSPYSHDGDSLSRSQDHI---PLAALPLLATSSSRYQGAVATVIARTNQA 542

  Fly   635 YHEFLKSEEGHGFSGQIVMLGDSMGSLLAYEALCRSNGSQPGTASGASNSGGDAATNI------N 693
            |..||:|.||.||.||:.::||.:|.:|.::|||.|  :..||.|..|:..|.....:      .
Human   543 YSAFLRSPEGAGFCGQVALIGDGVGGILGFDALCHS--ANAGTGSRGSSRRGSMNNELLSPEFGP 605

  Fly   694 THNPL----------SPRNS-----RLDDDERFIEADLDAKRLLVAPS------PRR-------- 729
            ..:||          ||..|     |:..|....|.:.....|..||:      |||
Human   606 VRDPLADGVEGLGRGSPEPSALPPQRIPSDMASPEPEGSQNSLQAAPATTSSWEPRRASTAFCPP 670

  Fly   730 RRSSSSSD--SRATKLDFEVCDFFMFGSPLSVVLAARK--LHDAKAALPRPNCHQVYNLFHPTDP 790
            ..||.:.|  |...:|||:|..||:|||||.:|||.||  :...:||..||.|.|:|||||..||
Human   671 AASSEAPDGPSSTARLDFKVSGFFLFGSPLGLVLALRKTVMPALEAAQMRPACEQIYNLFHAADP 735

  Fly   791 IASRLEPLLSARFSILAPVNVPRYAKYPLGNGQPLHLLEVIQSHPQHFNDGNNLLAGRRLSDASM 855
            .||||||||:.:|..:||:.||||.|:|||:|..|.|.:.:|:|...|.:...:|.     .::.
Human   736 CASRLEPLLAPKFQAIAPLTVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMLV-----PSTP 795

  Fly   856 QSTISGLIENVSLST--------------IHALQNKWWGTKRLDYALYCPEGLSNFPAHALPHLF 906
            .||.....:...|:|              :..:..:||||||:||:|||||.|:.||...|||||
Human   796 TSTSGAFWKGSELATDPPAQPAAPSTTSEVVKILERWWGTKRIDYSLYCPEALTAFPTVTLPHLF 860

  Fly   907 HASYWESPDVIAFILRQIGKFEGIPFVGSNDDKDNASFHPGQPREKWIKKRTSVKLKNVAANHRA 971
            |||||||.||:||||||:.:.|.....   :.::.:.:.|..|||||.:|||.||::||.:||||
Human   861 HASYWESADVVAFILRQVIEKERPQLA---ECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRA 922

  Fly   972 NDVIVQEGREQRLNARFMYGPLDMITLHGEKVDVHIMKDPPAGEWTFLSTEVTDKNGRISYSIPD 1036
            :|.:|.|||.|.|:.||||||||::||.||||||:||..|.:|:|....||||:.:||:::.:|.
Human   923 SDTVVCEGRPQVLSGRFMYGPLDVVTLTGEKVDVYIMTQPLSGKWIHFGTEVTNSSGRLTFPVPP 987

  Fly  1037 QVSLGYGIYPVKMVVRGDHTSVDCYMAVVPPLTECVVFSIDGSFTASMSVTGRDPKVRAGAVDVC 1101
            :.:||.|:|||:||||||||..:|.:.||...||.||||||||||||:|:.|.|||||||||||.
Human   988 ERALGIGVYPVRMVVRGDHTYAECCLTVVARGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVV 1052

  Fly  1102 RHWQELGYLLIYITGRPDMQQQRVVSWLSQHNFPHGLISFADGLSTDPLGHKTAYLNNLVQNHGI 1166
            ||||:.|||::|:|||||||:.|||:||||||||||::||.|||:.|||..|..:|.:|||...:
Human  1053 RHWQDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEVEL 1117

  Fly  1167 SITAAYGSSKDISVYTNVGMRTDQIFIVGKVGKKLQSNATVLSDGYAAHLAGLQAVGGSRPAKGN 1231
            :|.|.|||.||::||..:|:...|.:|||:..:|||:....|||||.|||..|:|...|..:.|.
Human  1118 NIVAGYGSPKDVAVYAALGLSPSQTYIVGRAVRKLQAQCQFLSDGYVAHLGQLEAGSHSHASSGP 1182

  Fly  1232 ARMVIPRGCFNLPGQTANPRRRSNAFELQLANISPSSSNINSPSS 1276
            .|..:.:..:.:.......|::|..    |.:..||.:....|.:
Human  1183 PRAALGKSSYGVAAPVDFLRKQSQL----LRSRGPSQAEREGPGT 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	172/266 (65%)
		DDHD	746..924	CDD:280937	91/193 (47%)
		LNS2	1072..1203	CDD:197870	82/130 (63%)
PITPNM1	NP_004901.2	SRPBCC_PITPNM1-2_like	1..257	CDD:176898	172/266 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..331		27/134 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..358		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..682		22/100 (22%)
		DDHD	689..879	CDD:280937	92/194 (47%)
		Peptidase_M14NE-CP-C_like	<964..>1028	CDD:304370	32/63 (51%)
		LNS2	1023..1154	CDD:197870	82/130 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1206..1244		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	392	1.000	Domainoid score	I778
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1054	1.000	Inparanoid score	I259
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S4786
OMA	1	1.010	-	-		QHG48872
OrthoDB	1	1.010	-	-		D122895at2759
OrthoFinder	1	1.000	-	-		FOG0002342
OrthoInspector	1	1.000	-	-		otm41394
orthoMCL	1	0.900	-	-		OOG6_104036
Panther	1	1.100	-	-	O	PTHR10658
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.830