DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgB and PAH1

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	NP_013888.1	Gene:	PAH1 / 855201	SGDID:	S000004775	Length:	862	Species:	Saccharomyces cerevisiae

Alignment Length:	817	Identity:	147/817 - (17%)
Similarity:	258/817 - (31%)	Gaps:	286/817 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 IRELERQTQLALAKKMG--------GGE-----ECSDDSVSEPYVSTAATAASTTGSERKKSAPA 303
            ::..:::.|:.:.:|:.        .||     |..|.....|.....:...|.|.|
Yeast    54 LKPSQKKVQVFINEKLSNMPMKLSDSGEAYFVFEMGDQVTDVPDELLVSPVMSATSS-------- 110

  Fly   304 VPPIVTQQPPSA--EASSDEEGEEEEDDDEDENDAIGTGVDLSANQGGSAQRSRSQSIQMAQKGK 366
             ||   |.|.::  |..::.|||.|.::.:.|...:.....|..|..|.:....|:
Yeast   111 -PP---QSPETSILEGGTEGEGEGENENKKKEKKVLEEPDFLDINDTGDSGSKNSE--------- 162

  Fly   367 FGSKGALHSPVGSAHSFDLQS----KKPHAKTAPRRHVANWRMERLEVDSKSNSDEEFFDCLDTN 427
              :.|:| ||..|:.:....|    |....:|...:...|.::..:.:.||.:::.:..  |||
Yeast   163 --TTGSL-SPTESSTTTPPDSVEERKLVEQRTKNFQQKLNKKLTEIHIPSKLDNNGDLL--LDT- 221

  Fly   428 ETNSLAKWSSLELLGEGDDSPPPHGGPSSAASVGGRGNSRQEDSIFNQDFLMR--VASERGNKRQ 490
                                               .|....::.:.:.|..::  :..|.||...
Yeast   222 -----------------------------------EGYKPNKNMMHDTDIQLKQLLKDEFGNDSD 251

  Fly   491 LRSSASVDRS----------H--DSSPPGSPSTPSCPTTILIL-VVHAGSVLD------------ 530
            :.|....|::          |  |.||||:|.|.:...::|.| .:.:||.|:
Yeast   252 ISSFIKEDKNGNIKIVNPYEHLTDLSPPGTPPTMATSGSVLGLDAMESGSTLNSLSSSPSGSDTE 316

  Fly   531 ----------AASELTAKKSDVTTFRGSFEAVMRQHYPSLLTHVTIKMVPCPSICTDALGILSSL 585
                      :.||.|:||...    ||.|...|......||:..:|          .|.:....
Yeast   317 DETSFSKEQSSKSEKTSKKGTA----GSGETEKRYIRTIRLTNDQLK----------CLNLTYGE 367

  Fly   586 SPYSFDASPSAADIPNIA-----DVPIGAIPLLSVASPEFHETVNKTVAAANIVYHEFLKSEEGH 645
            :...|......|.:.:..     ||||       |.| :...|:.|:.|..::
Yeast   368 NDLKFSVDHGKAIVTSKLFVWRWDVPI-------VIS-DIDGTITKSDALGHV------------ 412

  Fly   646 GFSGQIVMLGDS---MGSLLAYEALCRSNGSQ----PGTASGASNSGGDAATNINTHNPLSPRNS 703
                 :.|:|..   :|....:..:.| ||..    ...::|.::|......:|..:....|...
Yeast   413 -----LAMIGKDWTHLGVAKLFSEISR-NGYNILYLTARSAGQADSTRSYLRSIEQNGSKLPNGP 471

  Fly   704 RLDDDERFIEADLDAKRLLVAPSPRRRRSSSSSDSRATKLDFEVCD-----------FFM-FGSP 756
            .:...:|.:.|   .:|.::...|...:.:..:|.|:  |.||..|           ||. ||:.
Yeast   472 VILSPDRTMAA---LRREVILKKPEVFKIACLNDIRS--LYFEDSDNEVDTEEKSTPFFAGFGNR 531

  Fly   757 LSVVLAARKLHDAKAALPRPNCHQVYNLFHPTDPIASRLEPLLSARFSILAPVNVPRYAKYPLGN 821
            :                              ||.::.|             .|.:|....:.:..
Yeast   532 I------------------------------TDALSYR-------------TVGIPSSRIFTINT 553

  Fly   822 GQPLHLLEVIQSHPQHFNDGNNLLAGRRLSDASMQSTISGLIENVSLSTIHALQNKWWGTKRLDY 886
            ...:| :|:::            |||.|.|...:...:......|||.::....|    |..:..
Yeast   554 EGEVH-MELLE------------LAGYRSSYIHINELVDHFFPPVSLDSVDLRTN----TSMVPG 601

  Fly   887 ALYCPEG--LSNFPAH---ALPHLFH---------ASYWESPDVIAFILRQIGKFEGIPFVGSND 937
            :   |..  |.||.:.   ....||.         .::|..|      |..|.....|    |||
Yeast   602 S---PPNRTLDNFDSEITSGRKTLFRGNQEEKFTDVNFWRDP------LVDIDNLSDI----SND 653

  Fly   938 DKDNASFHPGQPREKWIKKRTSVKLKNVAANHRANDV 974
            |.||            |.:.|.|..::..:.:|||.|
Yeast   654 DSDN------------IDEDTDVSQQSNISRNRANSV 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	2/15 (13%)
		DDHD	746..924	CDD:280937	32/203 (16%)
		LNS2	1072..1203	CDD:197870
PAH1	NP_013888.1	SMP2	1..609	CDD:227415	124/724 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900