DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdgB and lpin1a

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	XP_005158866.1	Gene:	lpin1a / 799099	ZFINID:	ZDB-GENE-080722-2	Length:	920	Species:	Danio rerio

Alignment Length:	875	Identity:	167/875 - (19%)
Similarity:	259/875 - (29%)	Gaps:	327/875 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   608 GAIPLLSVASPE-------FH-------------ETVNKTVAAANIVYHEFLKSEEGHGF----- 647
            |.|.::.|..|:       ||             :.|:..:....:..|..| .|.|..|
Zfish    55 GCIDVIVVRQPDGTLQCSPFHVRFGKMGVLRSREKVVDIEINGEPVSLHMKL-GENGEAFFVKET 118

  Fly   648 --SGQIVMLGDSMGSLLAYEALCRSNGS-----QPGTASGASNSGGDAATNINTHNPLSPRNSRL 705
              .|::|      .|.||...:. |.||     |.|..:...:..|: .|.|.|..|:.|..
Zfish   119 EDDGEMV------PSYLATSPII-SEGSALMQAQMGKGTSRLSESGN-GTTIQTLGPMQPPG--- 172

  Fly   706 DDDERFIEADLDAKRLLVAPSPRRRRSSSSSDSRATKLDFEVCDFFMF------------GS-PL 757
                   ::.:..||     ..|||:|...|..|....|.|..|.|..            || .:
Zfish   173 -------DSSIMKKR-----RKRRRKSKVDSMKREDNGDSEDEDMFPIDMSSDDDDTEASGSRAM 225

  Fly   758 SVVLAARKLHDAK---------------------AALPRP-------NCHQVYNLFHPTDPIASR 794
            |..|.|.:|..|.                     .:||.|       :|.|...:||.||.....
Zfish   226 SHDLFAEQLKGASNTYMQSERNWAGVQSTGLEKTCSLPIPTNTGLSISCPQQSAMFHRTDSPNGS 290

  Fly   795 L-------EPLLSARFSILAPVN---------VPRYAK----YPLGNGQPLHLLEVIQSHPQHFN 839
            |       ..||.::.:...|.|         :|..||    .||.....:....:.:|...||.
Zfish   291 LPSTPKSDSELLDSQRNKGKPDNPEMLWTWGELPHAAKPSFRQPLPEPMVVTPKSIPRSESTHFR 355

  Fly   840 --DGNNLLAGR----RLSDASMQSTISGLIENVS-LSTI----------------HALQNKWWGT 881
              .|:.::..|    .:.|...:...|..:|.|. :|.:                ||:......:
Zfish   356 AITGDGMVESRGSVMYVPDIRTEEATSTAVEEVEPISVVAHLITELEDGRHSPGAHAISKTDSPS 420

  Fly   882 KRLD-----------------------YALYCPE------------------------------G 893
            ||.|                       .|||.|:                              |
Zfish   421 KRKDKRSPHLGSDGVYLDDITELEPEVAALYFPKSDGATSLRSGADSRSANQSPQSVGSSGMDSG 485

  Fly   894 LSNFPAHA--LPHLFHA---------------------SYWESPDVIAFI-----LRQIG-KF-- 927
            :.:|....  |||:..:                     ||.|..|..|.|     :.:|| |:
Zfish   486 VESFSDQLGDLPHIAISLCGGLSENREITREEFEERAISYQEFADNPAIIDDPNLVVKIGTKYYN 550

  Fly   928 --EGIPFV--------------GSNDDKDNASFHPGQPREKWIKKRTSVKLKNVAANHRANDVIV 976
              ...|.|              ..|..|:......|:....|..:.:|.|.::.|......|..:
Zfish   551 WTTAAPIVLAMQVFQKPLPTATVENIMKEKMPKKGGRWWFSWRGRNSSSKSESAADQIECGDESI 615

  Fly   977 QEGREQRLNARFMYGPLDMITLHGEKVDVHIMKDPPAGEWTFLSTEVTDKNG--------RISYS 1033
            :.|...||.........|    .|....:.:|..|          ||...:|        |:|
Zfish   616 RTGSVSRLKDESSSSEDD----SGGAKQIAVMNQP----------EVLHSSGGHCYRKTLRLS-- 664

  Fly  1034 IPDQ---VSLGYG----IYPVKMVVRGDHTSVDCYMAVVPPLTEC-------------VVFSIDG 1078
             |:|   ::|..|    ::.|....:|     .|         .|             |:..|||
Zfish   665 -PEQLASLNLKDGPNDVVFSVTTQYQG-----TC---------RCEGTIYLWNWDDKIVISDIDG 714

  Fly  1079 SFTAS------MSVTGRDPKVRAGAVDVCRHWQELGYLLIYIT----GRPDMQQQRVVSWLSQHN 1133
            :.|.|      :...|:| ....|...:.....:.||..:|.:    |..|| .:..:.|:::..
Zfish   715 TITRSDTLGHILPTLGKD-WTHQGIARLYHRVSQNGYKFMYCSARAIGMADM-TRGYLHWVNERG 777

  Fly  1134 ----------FPHGLIS--FADGLSTDPLGHKTAYL---NNLVQNHGISITAAYGS-SKDISVYT 1182
                      .|..|.|  ..:.:...|...|...|   .||...:.....||:|: :.|:..|.
Zfish   778 TMLPMGPVLLSPSSLFSAFHREVIEKKPEKFKIECLTDIKNLFYPNAEPFYAAFGNRATDVYSYK 842

  Fly  1183 NVGMRTDQIFIVGKVGKKLQSNATVLSDGY 1212
            .||:..::||.|...|:.:|.:|......|
Zfish   843 EVGVPLNRIFTVNPKGELIQEHAKTNISSY 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898
		DDHD	746..924	CDD:280937	59/342 (17%)
		LNS2	1072..1203	CDD:197870	35/156 (22%)
lpin1a	XP_005158866.1	Lipin_N	27..132	CDD:282436	17/83 (20%)
		Lipin_mid	499..589	CDD:293481	14/89 (16%)
		LNS2	659..884	CDD:285447	48/233 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900