DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgB and plrdgb

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	NP_571650.2	Gene:	plrdgb / 58096	ZFINID:	ZDB-GENE-000406-3	Length:	947	Species:	Danio rerio

Alignment Length:	953	Identity:	380/953 - (39%)
Similarity:	535/953 - (56%)	Gaps:	134/953 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 RRHVA-NWRMERLEVDSKSNSDEEFFDCLDTNETNS-----LAKWSSLELLGEGDDSPPPHGGPS 455
            |:|.| :||::.:..:|..:|||||||..|..|..:     :::|:|.:|:             .
Zfish    14 RKHSASHWRLQNIAQESVESSDEEFFDARDVMEGKTALLLEMSQWNSNDLV-------------E 65

  Fly   456 SAASVGGRGNSRQEDSIFNQDFLMRVASERGNKRQLRSSASVDRSHDSSPPGSPSTPSCPTTILI 520
            ...::|...:||:.        |.|:...|     ....:|||...|..       ..|.|.:||
Zfish    66 QIETLGHLEHSRES--------LYRLRHPR-----CAPQSSVDGLEDME-------RKCRTQLLI 110

  Fly   521 LVVHAGSVLDA-ASELTAKKSDVTTFRGSFEAVMRQHYPSLLTHVTIKMVPCPSICTDALGILSS 584
            ||:|.|.:||: ..:...|..|..|.....|.|.|.|:.:....:.:::||||.:|.||..::|:
Zfish   111 LVIHGGHILDSGGGDPGGKAGDAATLASVLERVARAHFQAAADSMLVRLVPCPPVCADAFTLVSN 175

  Fly   585 LSPYSFDASPSAADIPNIADVPIGAIPLLSVASPEFHETVNKTVAAANIVYHEFLKSEEGHGFSG 649
            |:|||:|.:..:..:.::   |:.|:|:|::|:|.:...|...:|.||.||..||:|.||.||:|
Zfish   176 LNPYSYDENCVSTSVDHL---PLAALPILAIAAPHYQNAVAAVIAQANQVYRNFLQSPEGVGFTG 237

  Fly   650 QIVMLGDSMGSLLAYEALCRSNGSQPGTASGASNSGGDAATNINTH---------NPLSPRNSRL 705
            |:.::.|.:|.:|.::|||.|...|..:..|.|       ||.:|.         |.|||   .|
Zfish   238 QVCLVADCVGGVLCFDALCFSGDKQHRSPEGGS-------TNNSTESLKEKPGVVNSLSP---TL 292

  Fly   706 DDDERFIEADLDAKR----LLVAPSPRRRRSSSSSDSRATK------------------------ 742
            ...:|..::::|...    |.....|..|:.|.|.|:....
Zfish   293 RGSKRLSKSNIDVSTPCDVLSGIRHPLIRKQSDSCDADVASGQREVFISSLSQDDQCGSRQALSP 357

  Fly   743 --LDFEVCDFFMFGSPLSVVLAARK--LHDAKAALPRPNCHQVYNLFHPTDPIASRLEPLLSARF 803
              .:|||.|.|:.|.||.:|||.|:  :.....|..||.|.|::|||:|:||.||||||||.:..
Zfish   358 GCFEFEVSDCFLLGCPLGLVLAMRRTVVPGVDVAQLRPACSQIFNLFYPSDPSASRLEPLLHSVL 422

  Fly   804 SILAPVNVPRYAKYPLGNGQPLHLLEVIQSHPQHFNDGNNLLAG-----------RRLSDASMQS 857
            :.|.|..||||.:.|||:|:...:::.:.   :|..:|.....|           ||.||.::..
Zfish   423 TQLPPFPVPRYQRCPLGDGRSTLIVDTVL---RHVTEGGVSADGAADQCYGGSVSRRGSDRAVPL 484

  Fly   858 TISGLI--ENVSLSTIHALQNKWWGTKRLDYALYCPEGLSNFPAHALPHLFHASYWESPDVIAFI 920
            ...|..  |.||:|.:   .::|||:|||||.||||:.|:.||..|||||||||||||.|.:|||
Zfish   485 GSEGTAPSEPVSISQV---CSRWWGSKRLDYVLYCPDVLTTFPTIALPHLFHASYWESTDAVAFI 546

  Fly   921 LRQIGKFEGIPFVGSNDDKDNASFHPGQPREKWIKKRTSVKLKNVAANHRANDVIVQEGREQRLN 985
            |||:.:.:.:. .|..|..|.....|..|||||:::||.|||:|:.||||.:||||.|...|.|.
Zfish   547 LRQVMRCDCLK-AGEADCSDAIPISPSSPREKWLRRRTHVKLRNITANHRVHDVIVTEDGPQTLV 610

  Fly   986 ARFMYGPLDMITLHGEKVDVHIMKDPPAGEWTFLSTEVTDKNGRISYSIPDQVSLGYGIYPVKMV 1050
            .|||||||||:||.||||||.:.....:|.|....|.||..:||:||:|||...||.|:||:|||
Zfish   611 GRFMYGPLDMVTLTGEKVDVFLKTQSGSGRWVLFDTVVTSSSGRVSYTIPDNKRLGVGVYPIKMV 675

  Fly  1051 VRGDHTSVDCYMAVVPPLTECVVFSIDGSFTASMSVTGRDPKVRAGAVDVCRHWQELGYLLIYIT 1115
            |:||.||.:.::.|:|...|||||||||||.||:|:.|.|||||.|||||.||||:||||:||||
Zfish   676 VKGDQTSAEAFLTVLPQGMECVVFSIDGSFAASVSLMGSDPKVRPGAVDVVRHWQDLGYLIIYIT 740

  Fly  1116 GRPDMQQQRVVSWLSQHNFPHGLISFADGLSTDPLGHKTAYLNNLVQNHGISITAAYGSSKDISV 1180
            ||||||:|||||||||||||.|::.|::||..|||..||.:|.:||:...|.|:|||||.||:||
Zfish   741 GRPDMQKQRVVSWLSQHNFPQGMVFFSEGLVHDPLRQKTIFLKSLVKECHIKISAAYGSMKDMSV 805

  Fly  1181 YTNVGMRTDQIFIVGKVGKKLQSNATVLSDGYAAHLAGLQAVGGSRPAKGNARMVIPRGCFNLPG 1245
            |:.:|:..:||:|||:..||.|.....||:||||||:.|:...|||..|.  |||:.:|.|.|..
Zfish   806 YSTLGLAPNQIYIVGRPSKKHQHQCQFLSEGYAAHLSTLEFEHGSRSKKN--RMVLRQGSFGLSS 868

  Fly  1246 QT--ANPR------------RRSNAFELQLANISPSSSNINSP 1274
            :|  .:|.            ||:    :.:...||.||::::|
Zfish   869 KTDFLSPSPDFLSCKRTPLLRRA----MSVQQPSPPSSSVSTP 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898
		DDHD	746..924	CDD:280937	86/192 (45%)
		LNS2	1072..1203	CDD:197870	86/130 (66%)
plrdgb	NP_571650.2	DDHD	363..551	CDD:308481	87/193 (45%)
		SMP2	<553..844	CDD:227415	167/291 (57%)
		LNS2	697..828	CDD:197870	86/130 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594940
Domainoid	1	1.000	376	1.000	Domainoid score	I824
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122895at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24651
orthoMCL	1	0.900	-	-		OOG6_104036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750