Protein Alignment rdgB and PITPNM2

DIOPT Version :9

• Sequence 1: NP_001259535.1
• Gene: rdgB / 32340
• FlyBaseID: FBgn0003218
• Length: 1297
• Species: Drosophila melanogaster
• Sequence 2: XP_024304866.1
• Gene: PITPNM2 / 57605
• HGNCID: 21044
• Length: 1435
• Species: Homo sapiens
• Alignment Length: 1523
• Identity: 619/1523 - (40%)
• Similarity: 824/1523 - (54%)
• Gaps: 375/1523 - (24%)

  Fly     1 MLIKEYRIPLPLTVEEYRIAQLYMIAKKSREESHGEGSGVEIIINEPYKDGPGGNGQYTKKIYHV 65
            |:|||||||||:|||||||||||||.||||.|::||||||||:.|.||.|||||:||||.|:|||
Human     1 MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILENRPYTDGPGGSGQYTHKVYHV 65

  Fly    66 GNHLPGWIKSLLPKSALTVEEEAWNAYPYTRTRYTCPFVEKFSLDIETYYYPDNGYQDNVFQLSG 130
            |.|:|.|.:|:|||:||.|.||:||||||||||:|||||||||:||||:|..|.|...:||.||.
Human    66 GMHIPSWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDAGENPDVFNLSP 130

  Fly   131 SDLRNRIVDVIDIVKDQLWGGDYVKEEDPKHFVSDKTGRGPLAEDWLEEYWREVKGKKQPTPRNM 195
            .:.....:|.||||||.:...:|..|||||.|.|.||.||||:|:|:|||      |||..|
Human   131 VEKNQLTIDFIDIVKDPVPHNEYKTEEDPKLFQSTKTQRGPLSENWIEEY------KKQVFP--- 186

  Fly   196 SLMTAYKICRVEFRYWGMQTKLEKFIHDVALRKMMLRAHRQAWAWQDEWFGLTIEDIRELERQTQ 260
             :|.|||:|:|||||||||:|:|:||||..||::|:|||||||.|||||:||::|:|||||::.|
Human   187 -IMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLSMENIRELEKEAQ 250

  Fly   261 LALAKKMG----GGEECSDDSVSEPYVSTAATAASTTGSERKKSAPAVPPIVTQQPPSAEASSDE 321
            |.|::||.    .|||.::      .|...|.:..|:|                :||...:|:.|
Human   251 LMLSRKMAQFNEDGEEATE------LVKHEAVSDQTSG----------------EPPEPSSSNGE 293

  Fly   322 EGEEEEDDDEDENDAIGTGVDLSANQGGSAQRSRSQSIQMAQKGKFGSKGALHSPVGSAHSFDLQ 386
                         ..:|.|  |......|::.|||           ..:||
Human   294 -------------PLVGRG--LKKQWSTSSKSSRS-----------SKRGA-------------- 318

  Fly   387 SKKPHAKTAPRRH-VANWRMERLEVDSKSNSDEEFFDC----LDTNE--TNSLAKWSSLELLGEG 444
                    :|.|| ::.|||:.:..||..:||:||||.    .||.|  ...:.||||.:|: :.
Human   319 --------SPSRHSISEWRMQSIARDSDESSDDEFFDAHEDLSDTEEMFPKDITKWSSNDLM-DK 374

  Fly   445 DDSPPPHGGPSSAASVGGRGNSRQEDSIFNQDFLMRVASERGNKRQLRSSASVDR-----SHDSS 504
            .:||.|                  ||:   ||.|.|..:.     :.|.::||::     ...|.
Human   375 IESPEP------------------EDT---QDGLYRQGAP-----EFRVASSVEQLNIIEDEVSQ 413

  Fly   505 PPGSPSTPSCPTTILILVVHAGSVLD-AASELTAKKSDVTTFRGSFEAVMRQHYPSLLTHVTIKM 568
            |..:|  || ...:|:||:|.|::|| .|.:.::||.|..|....|:.|||.||||.|..:.|::
Human   414 PLAAP--PS-KIHVLLLVLHGGTILDTGAGDPSSKKGDANTIANVFDTVMRVHYPSALGRLAIRL 475

  Fly   569 VPCPSICTDALGILSSLSPYSFDAS--PSAADIPNIADVPIGAIPLLSVASPEFHETVNKTVAAA 631
            ||||.:|:||..::|:|||||.|..  .|:.|     .:|:.|:|||:.:||::.|.|...:..|
Human   476 VPCPPVCSDAFALVSNLSPYSHDEGCLSSSQD-----HIPLAALPLLATSSPQYQEAVATVIQRA 535

  Fly   632 NIVYHEFLKSEEGHGFSGQIVMLGDSMGSLLAYEALCRSN------------------------- 671
            |:.|.:|:||:||..|:||:.::||.:|.:||::|||.||
Human   536 NLAYGDFIKSQEGMTFNGQVCLIGDCVGGILAFDALCYSNQPVSESQSSSRRGSVVSMQDNDLLS 600

  Fly   672 -----------------GSQPGTASGASNSGG---DAATNINTHNPLSPRNSRLDDDERFI---- 712
                             |...|::.|..:|||   :::.:::..|...||::..:|.:|.:
Human   601 PGILMNAAHCCGGGGGGGGGGGSSGGGGSSGGSSLESSRHLSRSNVDIPRSNGTEDPKRQLPRKR 665

  Fly   713 ------EAD-----------LDAKRLLVAPSPRRRRSSSSSDSRAT--KLDFEVCDFFMFGSPLS 758
                  |.|           |.|..|...|..|...||:..|....  :.|||:.|.|:||.||.
Human   666 SDSSTYELDTIQQHQAFLSSLHASVLRTEPCSRHSSSSTMLDGTGALGRFDFEITDLFLFGCPLG 730

  Fly   759 VVLAARKLHDAKAALP-------RPNCHQVYNLFHPTDPIASRLEPLLSARFSILAPVNVPRYAK 816
            :|||.|     |..:|       ||.|.||||||||.||.||||||||..||..|.|.:||||.:
Human   731 LVLALR-----KTVIPALDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQR 790

  Fly   817 YPLGNGQPLHLLEVIQSHPQHFNDGNNL------------------------------------- 844
            ||||:|....|:|.:|.:|:...:|..|
Human   791 YPLGDGCSTLLVETVQRNPELVLEGGPLAPLPHGDGFLETSMPVPAPTWQDGPRPGCAECVYPPL 855

  Fly   845 ----------------------LAG------------------------------------RRLS 851
                                  ||.                                    ||.|
Human   856 LVVTSASLVDLVLRDTPQSMPSLATHSSWDLGADVLQTHNAAFQEHGAPSSPGTAPASRGFRRAS 920

  Fly   852 DASMQSTISGLIENVSLSTI-----HALQN----------------------------------- 876
            :.|:.|.:||:.|:.:.|:|     .||.:
Human   921 EISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLER 985

  Fly   877 --------------KWWGTKRLDYALYCPEGLSNFPAHALPHLFHASYWESPDVIAFILRQIGKF 927
                          ||||.||:|||||||:.|:.||..|||||||||||||.||::|:|||:.:.
Human   986 APGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRH 1050

  Fly   928 EGIPFVGSNDDKDNASFHPGQPREKWIKKRTSVKLKNVAANHRANDVIVQEGREQRLNARFMYGP 992
            :....: ..|.|:.:.|.|.:|||||.:|||.|||:||.||||.||.:..|...|.|..||||||
Human  1051 DNSSIL-ELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGP 1114

  Fly   993 LDMITLHGEKVDVHIMKDPPAGEWTFLSTEVTDKNGRISYSIPDQVSLGYGIYPVKMVVRGDHTS 1057
            |||:||.|||||||||..||:|||.:|.|.||:.:||:||:||:...||.|:||:|||||||||.
Human  1115 LDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTF 1179

  Fly  1058 VDCYMAVVPPLTECVVFSIDGSFTASMSVTGRDPKVRAGAVDVCRHWQELGYLLIYITGRPDMQQ 1122
            .|.|:.|:|..||.|||||||||.||:|:.|.|||||||||||.||||:||||:||:|||||||:
Human  1180 ADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQK 1244

  Fly  1123 QRVVSWLSQHNFPHGLISFADGLSTDPLGHKTAYLNNLVQNHGISITAAYGSSKDISVYTNVGMR 1187
            ||||:||:|||||||::||.|||..|||.||..:|..|:....:.:.|||||:||::||:.:.:.
Human  1245 QRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLS 1309

  Fly  1188 TDQIFIVGKVGKKLQSNATVLSDGYAAHLAGLQAVGGSRPAKGNA-RMVIPRGCFNLPGQTANPR 1251
            ..||:|||:..||||.....::||||||||.|:....:|||:..| ||.:.:|.|.||||....|
Human  1310 PMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLR 1374

  Fly  1252 RRSNAFELQLANISPSSSNINSPSSGNH 1279
            .|::.    |..||.      .||..:|
Human  1375 SRNHL----LRTISA------QPSGPSH 1392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	172/266 (65%)
		DDHD	746..924	CDD:280937	101/333 (30%)
		LNS2	1072..1203	CDD:197870	83/130 (64%)
PITPNM2	XP_024304866.1	SRPBCC_PITPNM1-2_like	1..258	CDD:176898	172/266 (65%)
		DDHD	718..1048	CDD:308481	102/334 (31%)
		LNS2	1194..1325	CDD:197870	83/130 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	392	1.000	Domainoid score	I778
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7915
Inparanoid	1	1.050	1054	1.000	Inparanoid score	I259
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48872
OrthoDB	1	1.010	-	-		D122895at2759
OrthoFinder	1	1.000	-	-		FOG0002342
OrthoInspector	1	1.000	-	-		otm41394
orthoMCL	1	0.900	-	-		OOG6_104036
Panther	1	1.100	-	-	LDO	PTHR10658
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3231
SonicParanoid	1	1.000	-	-		X1383
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.870