DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgB and Lpin3

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	XP_038961442.1	Gene:	Lpin3 / 362261	RGDID:	1588534	Length:	845	Species:	Rattus norvegicus

Alignment Length:	969	Identity:	180/969 - (18%)
Similarity:	298/969 - (30%)	Gaps:	362/969 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 KFGSKGALHSPVGSAHSFDLQSKKPHAKTAPRRHVANWRMERLEVD---SKSNSDEEFF-DCLDT 426
            :||..|.|.|                     |..|.:..:....||   ...:|.|.|| ..||:
  Rat    51 RFGKLGVLRS---------------------REKVVDIEINGEPVDLHMKLGDSGEAFFVQELDS 94

  Fly   427 NETNSLAKWSSLELLGEGDDSPP-------PHGGPSSAASVGGRGNSRQEDSIFNQDFLMRVASE 484
            :|                :|.||       |.||.|...|....|.:.:.:.:        |.:.
  Rat    95 DE----------------EDVPPRLCTSPIPWGGLSGFPSDSQLGTASEPEGL--------VLTG 135

  Fly   485 RGNKRQLRSSASVDRSHDSSPPGSPSTPSCPTTILILVVHAGSVLDAASELTAKKSDVTTFRGSF 549
            |..:|:.|.....:.:.|||..               .:.||    |.||||..:..:..   |.
  Rat   136 RRKRRRRRKPRRREDAADSSSE---------------ELEAG----AESELTLLEKPMPE---SP 178

  Fly   550 EAVMRQHYPSLLTHVTIKMVP-CPSICTDALGILSS--LSPYSFDASPSAADIPNIADVPI---- 607
            .:..::..||....   .:.| ....||....:.|:  :||    .|.|..::..:...|:
  Rat   179 SSAWKEEEPSSQPK---DIYPYSDGECTPQANLSSADLMSP----KSDSELELRPLEPSPLRAES 236

  Fly   608 ------GAIPLLSVAS-PEFHETVNKTVAAANIVYHEFLKSEEGHGFSGQIVMLGDSMGSLLAYE 665
                  |.:|.::.|. |||                             .:|:  :||.     |
  Rat   237 HMQWAWGRLPKVAKAEHPEF-----------------------------SLVL--ESMA-----E 265

  Fly   666 ALCRSNGSQPGTASGASNSGGDAATNINTHNPLSPRNSRLDDDERFIEADLDAKR-------LLV 723
            |:|    :.||..|.:|.:|.|     ...:|......|    |.....|::|.|       .|.
  Rat   266 AIC----ALPGEPSPSSMAGVD-----TLRSPALQPGVR----EDMFHPDVEAYREETPMDSPLA 317

  Fly   724 APSPRRRRSSS---SSDSRATKLDFEVCDFFMFGSPLSVVLAAR-KLHDAKAALPRPNCHQVYNL 784
            ||..:..::.:   :....|||       .:.:.:|.|...:.| ::...:|:|.|.. |
  Rat   318 APESKETKTQNPRGTGHPPATK-------SWSWTTPESHTPSGRTEVSRGRASLKRSQ-H----- 369

  Fly   785 FHPTDPIASRLEPLLSARFSILAP-----VNVPRYAKYP-----LGNGQPLHLLEV--------- 830
            ..|:|.....|..|.|...::..|     :...|::: |     |.|....|..|.
  Rat   370 LGPSDIYLDDLPSLDSENVALYFPKSDCGMGARRWSE-PSNQKLLENPSREHTAECTLDSVDRIE 433

  Fly   831 --------------IQSHPQHFNDGNNLLAGRRLSD------------------ASMQSTISGLI 863
                          ::...||.....:|.....|.|                  |.|..::....
  Rat   434 LSLCGGLADTRDISLEKFTQHMVSYEDLTKNPGLLDDPNLVVKINEKHYNWAVAAPMILSLQAFQ 498

  Fly   864 ENVSLSTIHALQ--------NKWW-GTKRLDYALYCPEGLSNFPAHALPHLFHASYWESPDVIAF 919
            :|:..||:..||        .:|| ..:|.|           |||..     .::..|.    |.
  Rat   499 KNLPESTVDKLQKEKMPRKGGRWWFSWRRRD-----------FPAEE-----RSAQREK----AA 543

  Fly   920 ILRQIGKFEGIPFVGSNDDKDNA----------SFHPGQ-PREKWIKKRTSVKLKNVAANHRAND 973
            ..:|.|  |....:.|:||..::          |..||. |..|...:.:|.:::.:..|..|||
  Rat   544 TRKQQG--EKTEVLSSDDDVPDSPVILEVPPLPSSTPGYVPTYKKSLRLSSNQIRCLNLNEGAND 606

  Fly   974 VIVQEGREQRLNARFMYGPLDMITLHGEKVDVHIMKDPPAGEWTFLSTEVTDKNGRISYSIPDQV 1038
            |:.....:.:...|.             |..:::        |.:                .|:|
  Rat   607 VVFSVTTQYQGTCRC-------------KATIYL--------WNW----------------DDKV 634

  Fly  1039 SLGYGIYPVKMVVRGDHTSVDCYMAVVPPLTECVVFSIDGSFTAS------MSVTGRDPKVRAGA 1097
                                             |:..|||:.|.|      :...|:| ....|.
  Rat   635 ---------------------------------VISDIDGTITKSDALGHILPQLGKD-WTHQGI 665

  Fly  1098 VDVCRHWQELGYLLIYITGRP-DMQQ--QRVVSWLSQH--NFPHGLISFA----------DGLST 1147
            ..:.......||..:|.:.|. .|..  :..:.|:|:|  ..|.|.|..:          :.:..
  Rat   666 TSLYHKIHLNGYKFLYCSARAIGMAHLTKGYLQWVSEHGCGLPKGPILLSPSSLFSALHREVIEK 730

  Fly  1148 DPLGHKTAYLNNLVQ---NHGISITAAYGS-SKDISVYTNVGMRTDQIFIVGKVGKKLQ 1202
            .|...|.|.|:::.|   .......||:|: ..|:..|..||:...:||.|...|:.:|
  Rat   731 KPEVFKVACLSDIQQLFLPQRQPFYAAFGNRPNDVFAYRQVGLPESRIFTVNPRGELIQ 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898
		DDHD	746..924	CDD:280937	40/238 (17%)
		LNS2	1072..1203	CDD:197870	37/156 (24%)
Lpin3	XP_038961442.1	Lipin_N	1..107	CDD:398325	19/92 (21%)
		Lipin_mid	432..523	CDD:407117	13/90 (14%)
		LNS2	586..811	CDD:400509	48/275 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900