DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgB and Pitpnm1

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	XP_038939635.1	Gene:	Pitpnm1 / 361694	RGDID:	1306710	Length:	1263	Species:	Rattus norvegicus

Alignment Length:	1361	Identity:	579/1361 - (42%)
Similarity:	779/1361 - (57%)	Gaps:	204/1361 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLIKEYRIPLPLTVEEYRIAQLYMIAKKSREESHGEGSGVEIIINEPYKDGPGGNGQYTKKIYHV 65
            ||||||.|.||::::||::||||||.|||||||.||||||||:.|.||.||||||||||.|:|||
  Rat     1 MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGNGQYTHKVYHV 65

  Fly    66 GNHLPGWIKSLLPKSALTVEEEAWNAYPYTRTRYTCPFVEKFSLDIETYYYPDNGYQDNVFQLSG 130
            |:|:|||.::||||:||.||||:||||||||||||||||||||::|||||.||.|.|.|||.|||
  Rat    66 GSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSG 130

  Fly   131 SDLRNRIVDVIDIVKDQLWGGDYVKEEDPKHFVSDKTGRGPLAEDWLEEYWREVKGKKQPTPRNM 195
            ::.|.||:|.||||:|.:..|:|..||||:.:.|.||||||||:||       .:...|..|
  Rat   131 AERRQRILDTIDIVRDAVAPGEYKAEEDPRLYRSVKTGRGPLADDW-------ARTAAQTGP--- 185

  Fly   196 SLMTAYKICRVEFRYWGMQTKLEKFIHDV---------------------ALRKMMLRAHRQAWA 239
             ||.|||:|:|||||||||.|:|:|||||                     .||::|||||||||.
  Rat   186 -LMCAYKLCKVEFRYWGMQAKIEQFIHDVDKDTEFRERCRLPCNAFGKSTGLRRVMLRAHRQAWC 249

  Fly   240 WQDEWFGLTIEDIRELERQTQLALAKKMGGGEECSDDSVSEPYVSTAATAASTTGSERKKS-APA 303
            |||||..|::.|||.||.:|...||::|                     |...||||..:: .|.
  Rat   250 WQDEWIELSMADIRALEEETARMLAQRM---------------------AKCNTGSEGPEAQTPG 293

  Fly   304 VPPIVTQQPPSAEASSDEEGEEEEDDDEDENDAIGTGVDLSANQGGSAQRSRSQSIQMAQKGKFG 368
            .|...||  |....:...:|.|.....:...||          ..|....|.|:|...:|.|
  Rat   294 KPSTETQ--PGTRTAGTPDGPEAPPGPDASPDA----------SFGKQWSSSSRSSYSSQHG--- 343

  Fly   369 SKGALHSPVGSAHSFDLQSKKPHAKTAPRRHVANWRMERLEVDSKSNSDEEFFDC----LDTNET 429
              |.: ||                     :.::.|||:.:..||:::|:|||||.    .|::|.
  Rat   344 --GGV-SP---------------------QSLSEWRMQNIARDSENSSEEEFFDAHEGFSDSDEV 384

  Fly   430 --NSLAKWSSLELLGEGDDSPPPHGGPSSAASVGGRGNSRQEDSIFNQDFLMRVASERGNKRQLR 492
              ..:.||:|.:.:..........|.|..|                    :|.........|..|
  Rat   385 FPKEMTKWNSNDFIDAFASPTEVEGVPDPA--------------------IMATKGIEDEARAPR 429

  Fly   493 SSASVDRSHDSSPPGSPSTPSCPTTILILVVHAGSVLDAA-SELTAKKSDVTTFRGSFEAVMRQH 556
            .|..:|.:      |.....:|....|.|::|:||:||:. .:..:|::||.|...:||||.|.|
  Rat   430 DSEGLDGT------GDLGVEACSVHALFLILHSGSILDSGPGDTNSKQADVQTLSTAFEAVTRVH 488

  Fly   557 YPSLLTHVTIKMVPCPSICTDALGILSSLSPYSFDASPSAADIPNIADVPIGAIPLLSVASPEFH 621
            :|..|.||.:::||||.||..|..::|:|||||.|....:....:|   |:.|:|||:.:|..:.
  Rat   489 FPEALGHVALRLVPCPPICAAAYALVSNLSPYSHDGDSLSRSQDHI---PLAALPLLATSSSRYQ 550

  Fly   622 ETVNKTVAAANIVYHEFLKSEEGHGFSGQIVMLGDSMGSLLAYEALCRSNGSQPGTASGASNSGG 686
            ..|...:|..|..|..||:|.||.||.||:|::||.:|.:|.::|||.|  :..||.|..|:..|
  Rat   551 GAVATVIARTNQAYAAFLRSSEGTGFCGQVVLIGDGVGGILGFDALCHS--ASAGTGSRGSSRRG 613

  Fly   687 D----------------AATNINTHNPLSPRNS-----RLDDDERFIEADLDAKRLLVAPS---- 726
            .                .|..:......||..|     |...|....:.|.....|.|||:
  Rat   614 SMNNEMLSPEVGPVRDPLADGVEVLGRASPEPSALPAQRTSSDMANPDPDGSQNSLQVAPTVTSG 678

  Fly   727 -PRRRRSSS----SSD-----SRATKLDFEVCDFFMFGSPLSVVLAARK--LHDAKAALPRPNCH 779
             |||..::|    ||:     :.|.:|||:|..||:|||||.:|||.||  :...:.|..||.|.
  Rat   679 EPRRASTASCPPASSEAPDGPTNAARLDFKVSGFFLFGSPLGLVLALRKTVMPALEVAQMRPACE 743

  Fly   780 QVYNLFHPTDPIASRLEPLLSARFSILAPVNVPRYAKYPLGNGQPLHLLEVIQSHPQHFND---- 840
            |:|||||..||.||||||||:.:|..:||:.||||.|:|||:|..|.|.:.:|:|...|.:
  Rat   744 QIYNLFHAADPCASRLEPLLAPKFQAIAPLAVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEM 808

  Fly   841 ---------------GNNLLAGRRLSDASMQSTISGLIENVSLSTIHALQNKWWGTKRLDYALYC 890
                           ||. |.....:..:..||.|.:::         :.::|||.||:||:|||
  Rat   809 MVPSTPTSASGAFWKGNE-LGNEPAAQPAAPSTTSEVVK---------ILDRWWGNKRIDYSLYC 863

  Fly   891 PEGLSNFPAHALPHLFHASYWESPDVIAFILRQIGKFEGIPFVGSNDDKDNASFHPGQPREKWIK 955
            ||.|:.||...||||||||||||.||:||||||:.:.|....   .:.::.:.:.|..|||||.:
  Rat   864 PEALTAFPTVTLPHLFHASYWESADVVAFILRQVIEKERPQL---TECEEPSIYSPAFPREKWQR 925

  Fly   956 KRTSVKLKNVAANHRANDVIVQEGREQRLNARFMYGPLDMITLHGEKVDVHIMKDPPAGEWTFLS 1020
            |||.||::||.:||||:|.:|.|||.|.||.||||||||::||.||||||::|..|.:|:|....
  Rat   926 KRTQVKIRNVTSNHRASDTVVCEGRPQVLNGRFMYGPLDVVTLTGEKVDVYVMTQPLSGKWIHFG 990

  Fly  1021 TEVTDKNGRISYSIPDQVSLGYGIYPVKMVVRGDHTSVDCYMAVVPPLTECVVFSIDGSFTASMS 1085
            ||||:.:||:::.:|.:.:||.|:|||:||||||||..:|.:.||...||.||||||||||||:|
  Rat   991 TEVTNSSGRLTFPVPSERALGIGVYPVRMVVRGDHTYAECCLTVVSRGTEAVVFSIDGSFTASVS 1055

  Fly  1086 VTGRDPKVRAGAVDVCRHWQELGYLLIYITGRPDMQQQRVVSWLSQHNFPHGLISFADGLSTDPL 1150
            :.|.|||||||||||.||||:.|||::|:|||||||:.|||:||||||||||::||.|||:.|||
  Rat  1056 IMGSDPKVRAGAVDVVRHWQDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPL 1120

  Fly  1151 GHKTAYLNNLVQNHGISITAAYGSSKDISVYTNVGMRTDQIFIVGKVGKKLQSNATVLSDGYAAH 1215
            ..|..:|.:|||...::|.|.|||.||::||..:|:...|.:|||:..:|||:....|||||.||
  Rat  1121 RQKAMFLQSLVQEVELNIVAGYGSPKDVAVYAALGLSPSQTYIVGRAVRKLQAQCQFLSDGYVAH 1185

  Fly  1216 LAGLQAVGGSRPAKGNARMVIPRGCFNLPGQTANPRRRSNAFELQLANISPSSSNINSPSS 1276
            |..|:|...|....|..|..:.:..:.:.......|::|..    |.:..||..::..|.:
  Rat  1186 LGQLEAGSHSHAPSGPPRAALAKSSYAVAAPVDFLRKQSQL----LRSRGPSQVDLEGPGT 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	174/287 (61%)
		DDHD	746..924	CDD:280937	90/198 (45%)
		LNS2	1072..1203	CDD:197870	82/130 (63%)
Pitpnm1	XP_038939635.1	SRPBCC_PITPNM1-2_like	1..278	CDD:176898	175/308 (57%)
		DDHD	708..898	CDD:397132	91/199 (46%)
		LNS2	1042..1173	CDD:197870	82/130 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	391	1.000	Domainoid score	I750
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1085	1.000	Inparanoid score	I226
OMA	1	1.010	-	-		QHG48872
OrthoDB	1	1.010	-	-		D122895at2759
OrthoFinder	1	1.000	-	-		FOG0002342
OrthoInspector	1	1.000	-	-		otm45511
orthoMCL	1	0.900	-	-		OOG6_104036
Panther	1	1.100	-	-	O	PTHR10658
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840