DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgB and Lpin

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	NP_001188884.1	Gene:	Lpin / 35790	FlyBaseID:	FBgn0263593	Length:	1089	Species:	Drosophila melanogaster

Alignment Length:	1271	Identity:	251/1271 - (19%)
Similarity:	397/1271 - (31%)	Gaps:	489/1271 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 SLDIETYYYPDNGYQDNVFQLSGSDL-----RNRIVDV------IDIVKDQLWGGD-----YVKE 156
            ::|:......|..:|.:.|.:....|     |.::||:      :||   |:..||     :|:|
  Fly    26 AIDVIVVEQRDGEFQCSPFHVRFGKLGVLRSREKVVDIEINGVPVDI---QMKLGDSGEAFFVEE 87

  Fly   157 ----ED------------PKHFVS--DKTGRGPLAEDWLEEYWREVKGKKQ--------PTPRNM 195
                ||            |..|::  ||      |.|.:|:....|..|..        |.||..
  Fly    88 CLEDEDEELPANLATSPIPNSFLASRDK------ANDTMEDISGVVTDKNASEELLLPLPLPRRN 146

  Fly   196 SL---MTAYKICRVEFRYWGMQTKLEKFIHDVA-----------------LRKMMLRAHRQAWAW 240
            |:   ....|...||      .:|.|..:.|..                 |::...:..||.||.
  Fly   147 SIDFSKEEPKEAVVE------GSKFENQVSDYTQRRHTDNTLERRNLSEKLKEFTTQKIRQEWAE 205

  Fly   241 QDEWFGLTIEDIRELERQTQLALAKKMGGGEECSDDSVSEPYVSTAATAASTTGSERKKSAPAVP 305
            .:|.|                       .||:...||.|....|.|:..|.|     :|:.|||
  Fly   206 HEELF-----------------------QGEKKPADSDSLDNQSKASNEAET-----EKAIPAV- 241

  Fly   306 PIVTQQPPSAEASSDEEGEEEEDDDEDENDAIGTGVDLSANQGGSA-----------QRSRSQSI 359
                                 .:|.|.|.|.|...|:|:......|           :|.:||..
  Fly   242 ---------------------IEDTEKEKDQIKPDVNLTTVTTSEATKEVSKSKTKKRRKKSQMK 285

  Fly   360 QMAQKGKFGSKGALHSPVGSAHSFDLQSKKPHAKTAPRRHVANWRMERLEVDSKSNSDEEFFDCL 424
            :.||:     |.:..|.:|||...||    |.|:| |...|:|.......:.|.:|::
  Fly   286 KNAQR-----KNSSSSSLGSAGGGDL----PSAET-PSLGVSNIDEGDAPISSATNNN------- 333

  Fly   425 DTNETNSLAKWSSLELLGEGDDSP---PPHGGPSSAASVGGRGNSRQE-DSIFNQDFLMRVASER 485
            :|:.:|.....:.|.....|||||   .|| .|:|        |.|.: |..|..|..:......
  Fly   334 NTSSSNDEQLSAPLVTARTGDDSPLSEIPH-TPTS--------NPRLDLDIHFFSDTEITTPVGG 389

  Fly   486 GNKRQLRSSASVDRSHDSSPPGSPSTPSCPTTILILVVHAGSVLDAASELTAKKSDVTTFRGSFE 550
            |.....|::.           |.||||                :.:.|||              |
  Fly   390 GGAGSGRAAG-----------GRPSTP----------------IQSDSEL--------------E 413

  Fly   551 AVMRQHYPSLLTHVTIKMVPCPSICTDALGILSSLSPYSFDASPSAADIPNIADVPIGAIPLLSV 615
            ..||.:     .||..:               .|.:.:.:                 |.:|
  Fly   414 TTMRDN-----RHVVTE---------------ESTASWKW-----------------GELP---- 437

  Fly   616 ASPEFHETVNKTVAAANIVYHEF----------------LKSEEGHGFSGQIVMLGDSMGSL--- 661
             :||  :..|:.::||.:...|.                |:.|:|.|..|.|.:.....||:
  Fly   438 -TPE--QAKNEAMSAAQVQQSEHQSMLSNMFSFMKRANRLRKEKGVGEVGDIYLSDLDAGSMDPE 499

  Fly   662 --LAYEALCRSNGSQPGTASGASNSGGDAATNINTHNPLSPRNSRLDDDERFIEADLDAKRLLVA 724
              ..|.....|..:.|....|.|.:|        |..|.||  |.|::.::.|::|.|
  Fly   500 MAALYFPSPLSKAASPPEEDGESGNG--------TSLPHSP--SSLEEGQKSIDSDFD------- 547

  Fly   725 PSPRRRRSSS------------SSDSRATKLDFE----------VCDF-FMFGSPLSVVLAARKL 766
             ..:::|.::            .|:..|...|.|          ||.. .:|.||..||....|.
  Fly   548 -ETKQQRDNNRYLDFVAMSMCGMSEQGAPPSDEEFDRHLVNYPDVCKSPSIFSSPNLVVRLNGKY 611

  Fly   767 HDAKAALP---------RPNCHQVYNLFHPTDPIASRLEPLLSARFSILAPVNVPRYAKYPLGNG 822
            :...||.|         :|..|..             :|.|:|...
  Fly   612 YTWMAACPIVMTMITFQKPLTHDA-------------IEQLMSQTV------------------- 644

  Fly   823 QPLHLLEVIQSHPQHFNDGNNLLAGRRLSDASMQSTISGLIENVSLSTIHALQNK--WWGTKRLD 885
                             || ..|.|....:|..|:...|             |.|  ||..:|..
  Fly   645 -----------------DG-KCLPGDEKQEAVAQADNGG-------------QTKRYWWSWRRSQ 678

  Fly   886 YALYCPEGLSNFPAHALPHLFHASYWESPDVIAFILRQIGKFEGIPFVGSNDDKDN----ASFHP 946
            .|  .|..|:|  .|.:|                    :||          |:||.    .:...
  Fly   679 DA--APNHLNN--THGMP--------------------LGK----------DEKDGDQAAVATQT 709

  Fly   947 GQPREKWIKKRTSVKLKNVAANHRANDVIVQEGREQRLNARFMYGPLDMITLHGEKVDVHIMKDP 1011
            .:|....|...|..|          :|.:|...     |...:...|:.:|:...|.|     :|
  Fly   710 SRPTSPDITDPTLSK----------SDSLVNAE-----NTSALVDNLEELTMASNKSD-----EP 754

  Fly  1012 PAGEWTFLSTEVTDKNGRISYSIPDQVSLGYGIYPVKMVVRGDH---TSVDCYMAVVPPLTECVV 1073
                     .|...|:.|:|.:...:::|..|:..::..|...:   |...||:.......:.|:
  Fly   755 ---------KERYKKSLRLSSAAIKKLNLKEGMNEIEFSVTTAYQGTTRCKCYLFRWKHNDKVVI 810

  Fly  1074 FSIDGSFTAS------MSVTGRDPKVRAGAVDVCRHWQELGYLLIYITGRPDMQQQRVVSWLSQH 1132
            ..|||:.|.|      :.:.|:| ..:.|...:....::.||.|:|::.|...|.:....:|  .
  Fly   811 SDIDGTITKSDVLGHILPMVGKD-WAQLGVAQLFSKIEQNGYKLLYLSARAIGQSRVTREYL--R 872

  Fly  1133 NFPHGLISFADG-LSTDPLGHKTAYLNNLVQNHGISIT------------------AAYGSS-KD 1177
            :...|.:...|| |..:|....:|:...:::.......                  |.||:. .|
  Fly   873 SIRQGNVMLPDGPLLLNPTSLISAFHREVIEKKPEQFKIACLSDIRDLFPDKEPFYAGYGNRIND 937

  Fly  1178 ISVYTNVGMRTDQIFIVGKVGK-KLQSNATVLSDGY 1212
            :..|..||:...:||.:...|: |.:...|..|.||
  Fly   938 VWAYRAVGIPIMRIFTINTKGELKHELTQTFQSSGY 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	43/221 (19%)
		DDHD	746..924	CDD:280937	35/199 (18%)
		LNS2	1072..1203	CDD:197870	33/157 (21%)
Lpin	NP_001188884.1	Lipin_N	1..103	CDD:282436	17/79 (22%)
		Lipin_mid	562..671	CDD:293481	29/171 (17%)
		LNS2	760..985	CDD:285447	46/217 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900