DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgB and Pitpnm3

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	XP_006533626.1	Gene:	Pitpnm3 / 327958	MGIID:	2685726	Length:	975	Species:	Mus musculus

Alignment Length:	1028	Identity:	427/1028 - (41%)
Similarity:	581/1028 - (56%)	Gaps:	159/1028 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 MAQKGKFGSKGALHSPVGSAHSFDLQSKKPHAKTAPRRHVANWRMERLEVDSKSNSDEEFFDCLD 425
            ||:.|..|..    ||.|.                     |.|.:..:..||..:||:||||..:
Mouse     1 MAKAGSAGGP----SPGGG---------------------APWHLRNVLSDSVESSDDEFFDARE 40

  Fly   426 --TNETNS----LAKWSS------LELLGEGDDSPPPHGGPSSAASVGGRGNSRQEDSIFNQDFL 478
              ....|:    :::|||      :|.:|:.|:    ..|..:.|........:|.:       |
Mouse    41 EVAEGKNAILIGMSQWSSNDLVEQIETIGKLDE----RQGDGATACTSSILQEKQRE-------L 94

  Fly   479 MRVASERGNKRQLRSSASVDRSHDSSPPGSPSTPSCPTTILILVVHAGSVLDAAS-ELTAKKSDV 542
            .||:..|   ::..:..|:: .|:....|. |..||.|.:|:||:|.|:|||..| :.:.|.:|:
Mouse    95 YRVSLRR---QRFPAQGSIE-IHEDGEEGC-SQRSCKTHVLLLVLHGGNVLDTGSGDPSCKAADI 154

  Fly   543 TTFRGSFEAVMRQHYPSLLTHVTIKMVPCPSICTDALGILSSLSPYSFDAS--PSAADIPNIADV 605
            .||....|.|||.|:|:.|.|:.||.||||:||::|..::|:|:|||.|..  .::.|     .|
Mouse   155 HTFSSVLEKVMRAHFPAALGHILIKFVPCPAICSEAFSLVSNLNPYSHDEGCLGTSQD-----HV 214

  Fly   606 PIGAIPLLSVASPEFHETVNKTVAAANIVYHEFLKSEEGHGFSGQIVMLGDSMGSLLAYEALCRS 670
            |:.|:|||:::||::.:.|...:..||.:|.|||||.:|.||:||:.::||.:|.|||::|:|.|
Mouse   215 PLAALPLLAISSPQYQDAVATVIERANHIYGEFLKSSDGIGFNGQVCLIGDCVGGLLAFDAICYS 279

  Fly   671 ---NGSQPGTAS--GASNSGGDAATNINTHNPL--SPRNSRLDDDERFIEADLDAKRLLVAPSPR 728
               :|..||::|  |:.:|..|....:.....|  |.|.|:.:.|......|.|.||    |.||
Mouse   280 AGPSGDSPGSSSRKGSISSTQDTPVVVEEDCSLASSKRLSKSNVDVSSGVEDEDPKR----PLPR 340

  Fly   729 RRRSSSSSDSRAT------------------------------------KLDFEVCDFFMFGSPL 757
            ::..||:.|..|.                                    :.||:|.|||:|||||
Mouse   341 KQSDSSTYDCEAITQHHAFLSSSIHSSVLKDEAEAPAAGTPQLSEVSLGRFDFDVSDFFLFGSPL 405

  Fly   758 SVVLAARKLHDAKAALP-------RPNCHQVYNLFHPTDPIASRLEPLLSARFSILAPVNVPRYA 815
            .:|||.|     :..||       ||.|.|||:.||..||.||||||||..:|.::.||:||||.
Mouse   406 GLVLAMR-----RTVLPGIDGFQMRPACSQVYSFFHCADPSASRLEPLLEPKFHLVPPVSVPRYQ 465

  Fly   816 KYPLGNGQPLHLLEVIQSHPQHFNDGNN-----LL--------------AGRRLSDASMQSTISG 861
            ::|||:||.|.|.:.:.:|...|.:|::     ||              ..||||..|..|..|.
Mouse   466 RFPLGDGQSLLLADALHTHSPLFLEGSSRGSPPLLDAPASPPQAPRFQRTERRLSKGSSHSDSSE 530

  Fly   862 LIENVSLSTIHALQNKWWGTKRLDYALYCPEGLSNFPAHALPHLFHASYWESPDVIAFILRQIGK 926
            ..::::......:..|||||||:|||||||:.|:.||..|||||||||||||.||:||||||:.:
Mouse   531 SSDSLAPMGASRITAKWWGTKRIDYALYCPDVLTAFPTVALPHLFHASYWESTDVVAFILRQVMR 595

  Fly   927 FEGIPFVGSNDDKDNASFHPGQPREKWIKKRTSVKLKNVAANHRANDVIVQEGREQRLNARFMYG 991
            :|... |..:...|..:..|..|||||::|||.|||:||.|||||||||..|...|.|..|||||
Mouse   596 YESAS-VKESTGLDPTALSPANPREKWLRKRTQVKLRNVTANHRANDVIAAEDGPQVLVGRFMYG 659

  Fly   992 PLDMITLHGEKVDVHIMKDPPAGEWTFLSTEVTDKNGRISYSIPDQVSLGYGIYPVKMVVRGDHT 1056
            ||||:.|.|||||:.:|.:|.:|.|..|.||:|:.:|||:|::|....||.|:||||||||||.|
Mouse   660 PLDMVALTGEKVDILVMTEPSSGRWVHLDTEITNNSGRITYNVPRPRRLGVGVYPVKMVVRGDQT 724

  Fly  1057 SVDCYMAVVPPLTECVVFSIDGSFTASMSVTGRDPKVRAGAVDVCRHWQELGYLLIYITGRPDMQ 1121
            ....|:.|:|...|||||||||||.||:|:.|.|||||.|||||.||||:|||:::|||||||||
Mouse   725 CAMSYLTVLPRGMECVVFSIDGSFAASVSIMGSDPKVRPGAVDVVRHWQDLGYMILYITGRPDMQ 789

  Fly  1122 QQRVVSWLSQHNFPHGLISFADGLSTDPLGHKTAYLNNLVQNHGISITAAYGSSKDISVYTNVGM 1186
            :|||||||||||||.|:|.|:|||..|||..|..:|.||:|...|.|||||||:||||||:.:|:
Mouse   790 KQRVVSWLSQHNFPQGMIFFSDGLVHDPLRQKAIFLRNLMQECFIKITAAYGSTKDISVYSVLGL 854

  Fly  1187 RTDQIFIVGKVGKKLQSNATVLSDGYAAHLAGLQAVGGSRPAKGNARMVIPRGCFNLPGQTANPR 1251
            ...||||||:..||.|:....||:|||||||.|:|...|||.|.|:||::.:|.|.|..|....|
Mouse   855 PASQIFIVGRSTKKYQTQCQFLSEGYAAHLAALEASHRSRPKKNNSRMILRKGSFGLHAQPEFLR 919

  Fly  1252 RRSN---AFELQ-----LANISPSSSNINSPSSGNHILLAQLIENAIEKDTPA 1296
            :|::   ...:|     .||..|..:.....|..:|           |:..||
Mouse   920 KRNHLRRTMSVQQPDPPAANPKPERAQSQPESDKDH-----------ERPLPA 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898
		DDHD	746..924	CDD:280937	96/203 (47%)
		LNS2	1072..1203	CDD:197870	89/130 (68%)
Pitpnm3	XP_006533626.1	DDHD	394..594	CDD:367219	97/204 (48%)
Pitpnm3	XP_006533626.1	LNS2	740..870	CDD:197870	89/129 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I787
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122895at2759
OrthoFinder	1	1.000	-	-		FOG0002342
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3231
SonicParanoid	1	1.000	-	-		X1383
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.710