DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgB and Lpin2

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	XP_006245724.1	Gene:	Lpin2 / 316737	RGDID:	1304588	Length:	932	Species:	Rattus norvegicus

Alignment Length:	1029	Identity:	181/1029 - (17%)
Similarity:	316/1029 - (30%)	Gaps:	355/1029 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 LAKKMG-GGEECSDDSVSEPYVSTAATAASTTGSERKKSAPAVPPIVTQ-------QPPSAEASS 319
            |..|:| .||....:...|.|             |:..:..|..||.|:       .||..::|.
  Rat   114 LHMKLGDNGEAFFVEETEEEY-------------EKLPAYLATSPIPTEDQFFKHIDPPLVKSSG 165

  Fly   320 DEEGEEEEDDDED-ENDAIGTGVDLSANQGGSAQRSRSQSIQMAQKGKFGSKGALHSPVGSAHSF 383
            :|...:..|.... |::|:.|...:.     ..:|.|.:..|..:|
  Rat   166 NERPPQSSDVSHTLESEAVFTPSSVK-----KKKRRRKKCKQDNRK------------------- 206

  Fly   384 DLQSKKPHAKTAPRRHVANWRMERLEVDSKSNSDEEFFDCLDTNETNSLAKWSSLELLGEGD--D 446
            :.|:..|.|:...              |...:||:|        :....|:.||...|.|.|  :
  Rat   207 EEQAASPVAEDVG--------------DVAVSSDDE--------KRAQAARGSSNASLKEEDYKE 249

  Fly   447 SPPPHGGPSSAASVGGRGNSRQEDSIFNQDFLMRVASERGNKRQLRSSASVDRS----------- 500
            .||.|.|.:...|.|       :.|.....:...|..:..::.:::.|.|:.||
  Rat   250 PPPFHSGDNYPLSDG-------DWSPLETSYPQTVCPKSDSELEVKPSESLLRSESHMEWTWGGF 307

  Fly   501 -----------HDSSPPGSPSTPSCPTTILILVVHAGSVLDAASELTAKKSDVTTFRGSFEAVMR 554
                       :|..|..:..|||..|...::......:.:...:.|.:.:..|..:....|:.:
  Rat   308 PESTKVSKRERYDYHPRTATITPSENTHFRVIPSEDSLIREVEKDATVEDTTCTIVKPKPRALCK 372

  Fly   555 QHYPSLLTHVTIKMVPCPSICTDALGILSSLSPYSFDASPSAADIPN-IADVPIGAIPLLSVASP 618
            |...:..|.:....:..|.|.:            :.||.|    :|: .|:.|....|...|.||
  Rat   373 QLSDAASTELPESPLEAPQISS------------TLDADP----VPSPSAEAPSEPKPAAKVDSP 421

  Fly   619 EFHETVNKTV--AAANIVYHEFLKSEEGHGFSGQIVMLGDSMGSLLAYEALCRSNGSQPG----- 676
            ...:.|:|..  ...:.:|.:.||:.|     .::..|            ....:.:.||
  Rat   422 TKRKGVHKRSQHQGPDDIYLDDLKALE-----PEVAAL------------YFPKSDTDPGSRQWP 469

  Fly   677 ---TASGASN--SGGDAATNINTHNPLSPRNSRLDDDERFIEADLDAKRLLVAPSPRRRRSSSSS 736
               |.||:.:  |.|.||.:..|              |...::.:|...:.::..     ...|.
  Rat   470 ESDTFSGSQSPQSVGSAAADSGT--------------ECLSDSAMDLPDVTLSLC-----GGLSE 515

  Fly   737 DSRATKLDFEVCDFFMFGSPLSVVLAARKLHDAKAALPRPN-CHQVYNLFHPTDPIASRLEPLLS 800
            :...:|..|           :..::...:..:....:..|| ..::||.::
  Rat   516 NGEISKEKF-----------MEHIITYHEFAENPGLIDNPNLVIRIYNRYY-------------- 555

  Fly   801 ARFSILAPVNVPRYAKYPLGNGQPLHLLEVIQSHPQHFNDGNNLLAGRRLSDASMQSTISGLIEN 865
             .:::.||:               :..|:|.|               :.|..|:::|.:...:..
  Rat   556 -NWALAAPM---------------ILSLQVFQ---------------KSLPKATVESWVKDKMPK 589

  Fly   866 VSLSTIHALQNKWW-------GTKRLDYALYCPEGLSNF-PAHALPHLFHASYWESPDVIAFILR 922
            .|        .:||       .||:|...   .||.|.. ||:.||     |..|.|
  Rat   590 KS--------GRWWFWRKKESMTKQLPET---KEGKSEVPPANDLP-----SGTEEP-------- 630

  Fly   923 QIGKFEGIPFVGSNDDKDNASFHPGQPREKWIKKRTSVKLKNVAANHRANDVIVQEGREQRLNAR 987
                                                      |:|....||....|| .|.|...
  Rat   631 ------------------------------------------VSARPAENDTSSDEG-SQELEET 652

  Fly   988 FMYGPLDMITLHGEKVDVHIMKDPPAGEWTFLSTEVTDKNGRISYSIPDQVSLGYG----IYPVK 1048
            ....|:.|.||                  :...|....|:.|:|.....::.|..|    ::.:.
  Rat   653 IKVDPISMETL------------------SHCGTASYKKSLRLSSDQIAKLKLHDGPNDVVFSIT 699

  Fly  1049 MVVRGDHTSVDCYMAVVPPL----TECVVFSIDGSFTAS------MSVTGRDPKVRAGAVDVCRH 1103
            ...:|     .|..|....|    .:.::..|||:.|.|      :...|:| ....|...:...
  Rat   700 TQYQG-----TCRCAGTIYLWNWNDKVIISDIDGTITKSDALGQILPQLGKD-WTHQGIARLYHS 758

  Fly  1104 WQELGYLLIYIT----GRPDMQQQRVVSWLSQHN--FPHGLISFA----------DGLSTDPLGH 1152
            ..|.||..:|.:    |..|| .:..:.|::...  .|.|.:..:          :.:...|...
  Rat   759 INENGYKFLYCSARAIGMADM-TRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIEKKPEKF 822

  Fly  1153 KTAYLN---NLVQNHGISITAAYGS-SKDISVYTNVGMRTDQIFIVGKVGKKLQ 1202
            |...||   ||.........||:|: ..|:..||.||:...:||.|...|:.:|
  Rat   823 KIECLNDIKNLFAPSRQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQ 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	2/4 (50%)
		DDHD	746..924	CDD:280937	28/186 (15%)
		LNS2	1072..1203	CDD:197870	37/157 (24%)
Lpin2	XP_006245724.1	Lipin_N	39..144	CDD:282436	9/42 (21%)
		Lipin_mid	505..595	CDD:293481	16/158 (10%)
		LNS2	673..898	CDD:285447	46/211 (22%)
		AF1Q	<912..>932	CDD:259154
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900