Protein Alignment rdgB and Pitpnm1

DIOPT Version :10

• Sequence 1: NP_001259535.1
• Gene: rdgB / 32340
• FlyBaseID: FBgn0003218
• Length: 1297
• Species: Drosophila melanogaster
• Sequence 2: NP_032877.1
• Gene: Pitpnm1 / 18739
• MGIID: 1197524
• Length: 1243
• Species: Mus musculus
• Alignment Length: 1341
• Identity: 580/1341 - (43%)
• Similarity: 787/1341 - (58%)
• Gaps: 184/1341 - (13%)

  Fly     1 MLIKEYRIPLPLTVEEYRIAQLYMIAKKSREESHGEGSGVEIIINEPYKDGPGGNGQYTKKIYHV 65
            ||||||.|.||::::||::||||||.|||||||.||||||||:.|.||.||||||||||.|:|||
Mouse     1 MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGNGQYTHKVYHV 65

  Fly    66 GNHLPGWIKSLLPKSALTVEEEAWNAYPYTRTRYTCPFVEKFSLDIETYYYPDNGYQDNVFQLSG 130
            |:|:|||.::||||:||.||||:||||||||||||||||||||::|||||.||.|.|.|||.|||
Mouse    66 GSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSG 130

  Fly   131 SDLRNRIVDVIDIVKDQLWGGDYVKEEDPKHFVSDKTGRGPLAEDWLEEYWREVKGKKQPTPRNM 195
            ::.|.||||.||||:|.:..|:|..||||:.:.|.||||||||:||       .:...|..|
Mouse   131 AERRQRIVDTIDIVRDAVAPGEYKAEEDPRLYRSAKTGRGPLADDW-------ARTAAQTGP--- 185

  Fly   196 SLMTAYKICRVEFRYWGMQTKLEKFIHDVALRKMMLRAHRQAWAWQDEWFGLTIEDIRELERQTQ 260
             ||.|||:|:|||||||||.|:|:|||||.||::|||||||||.|||||..|::.|||.||.:|.
Mouse   186 -LMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWIELSMADIRALEEETA 249

  Fly   261 LALAKKMGGGEECSDDSVSEPYVSTAATAASTTGSERKKSAPAVPPIVTQQPPSAEASSDEEGEE 325
            ..||::|.   :|:..|..    ..|.|...::...|..::.|..|...:.||..:||.|.
Mouse   250 RMLAQRMA---KCNTGSEG----PEAQTPGKSSTEARPGTSTAGTPDGPEAPPGPDASPDA---- 303

  Fly   326 EEDDDEDENDAIGTGVDLSANQGGSAQRSRSQSIQMAQKGKFGSKGALHSPVGSAHSFDLQSKKP 390
                                 ..|....|.|:|...:|.|     |.: ||
Mouse   304 ---------------------SFGKQWSSSSRSSYSSQHG-----GGV-SP-------------- 327

  Fly   391 HAKTAPRRHVANWRMERLEVDSKSNSDEEFFDC----LDTNET--NSLAKWSSLELLGEGDDSPP 449
                   :.::.|||:.:..||:::|:|||||.    .|::|.  ..:.||:|.:.: :...||.
Mouse   328 -------QSLSEWRMQNIARDSENSSEEEFFDAHEGFSDSDEVFPKEMTKWNSNDFI-DAFASPT 384

  Fly   450 PHGG---PSSAASVGGRGNSRQEDSIFNQDFLMRVASERGNKRQLRSSASVDRSHDSSPPGSPST 511
            ...|   |:..|:.|....:|..                      |.|..:|.:      |....
Mouse   385 EVEGVPDPTVMATKGIEDGARAP----------------------RDSEGLDGA------GDLVV 421

  Fly   512 PSCPTTILILVVHAGSVLDAA-SELTAKKSDVTTFRGSFEAVMRQHYPSLLTHVTIKMVPCPSIC 575
            .:|....|.|::|:||:||:. .:..:|::||.|...:||||.|.|:|..|.||.:::||||.||
Mouse   422 EACSVHALFLILHSGSILDSGPGDTNSKQADVQTLSTAFEAVTRVHFPEALGHVALRLVPCPPIC 486

  Fly   576 TDALGILSSLSPYSFDASPSAADIPNIADVPIGAIPLLSVASPEFHETVNKTVAAANIVYHEFLK 640
            ..|..::|:|||||.|....:....:|   |:.|:|||:.:|..:...|...:|..|..|..||:
Mouse   487 AAAYALVSNLSPYSHDGDSLSRSQDHI---PLAALPLLATSSSRYQGAVATVIARTNQAYAAFLR 548

  Fly   641 SEEGHGFSGQIVMLGDSMGSLLAYEALCRSNGSQPGTASGASNSGG---------------DAAT 690
            |.||.||.||:|::||.:|.:|.::|||.|..:.|| :.|:|..|.               ..|.
Mouse   549 SSEGTGFCGQVVLIGDGVGGILGFDALCHSASAGPG-SRGSSRRGSMNNEMLSPEVGPVRDPLAD 612

  Fly   691 NINTHNPLSPRNSRLDDDERFIE---ADLDAKR--LLVAPS------PRRRRSSS----SSD--- 737
            .:......||..|.|.....|.:   .|.|..:  |.||.:      |||..::|    ||:
Mouse   613 GVEVLGRASPEPSALPAQRTFSDMANPDPDGSQNSLQVASTATSSGEPRRASTASCPPASSEAPD 677

  Fly   738 --SRATKLDFEVCDFFMFGSPLSVVLAARK--LHDAKAALPRPNCHQVYNLFHPTDPIASRLEPL 798
              :.|.:|||:|..||:|||||.:|||.||  :...:.|..||.|.|:|||||..||.|||||||
Mouse   678 GPTNAARLDFKVSGFFLFGSPLGLVLALRKTVMPALEVAQLRPACEQIYNLFHAADPCASRLEPL 742

  Fly   799 LSARFSILAPVNVPRYAKYPLGNGQPLHLLEVIQSHPQHFNDGNNLLA-------------GRRL 850
            |:.:|..:||:.||||.|:|||:|..|.|.:.:|:|...|.:...::.             |..|
Mouse   743 LAPKFQAIAPLAVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMMVPSTPTSASGAFWKGSEL 807

  Fly   851 -----SDASMQSTISGLIENVSLSTIHALQNKWWGTKRLDYALYCPEGLSNFPAHALPHLFHASY 910
                 |..:..||.|.:::         :.::|||.||:||:|||||.|:.||...|||||||||
Mouse   808 GNEPASQTAAPSTTSEVVK---------ILDRWWGNKRIDYSLYCPEALTAFPTVTLPHLFHASY 863

  Fly   911 WESPDVIAFILRQIGKFEGIPFVGSNDDKDNASFHPGQPREKWIKKRTSVKLKNVAANHRANDVI 975
            |||.||:||||||:.:.|....   .:.::.:.:.|..|||||.:|||.||::||.:||||:|.:
Mouse   864 WESADVVAFILRQVIEKERPQL---TECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRASDTV 925

  Fly   976 VQEGREQRLNARFMYGPLDMITLHGEKVDVHIMKDPPAGEWTFLSTEVTDKNGRISYSIPDQVSL 1040
            |.|||.|.||.||||||||::||.||||||::|..|.:|:|....||||:.:||:::.:|.:.:|
Mouse   926 VCEGRPQVLNGRFMYGPLDVVTLTGEKVDVYVMTQPLSGKWIHFGTEVTNSSGRLTFPVPSERAL 990

  Fly  1041 GYGIYPVKMVVRGDHTSVDCYMAVVPPLTECVVFSIDGSFTASMSVTGRDPKVRAGAVDVCRHWQ 1105
            |.|:|||:||||||||..:|.:.||...||.||||||||||||:|:.|.|||||||||||.||||
Mouse   991 GIGVYPVRMVVRGDHTYAECCLTVVSRGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQ 1055

  Fly  1106 ELGYLLIYITGRPDMQQQRVVSWLSQHNFPHGLISFADGLSTDPLGHKTAYLNNLVQNHGISITA 1170
            :.|||::|:|||||||:.|||:||||||||||::||.|||:.|||..|..:|.:|||...::|.|
Mouse  1056 DSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEVELNIVA 1120

  Fly  1171 AYGSSKDISVYTNVGMRTDQIFIVGKVGKKLQSNATVLSDGYAAHLAGLQAVGGSRPAKGNARMV 1235
            .|||.||::||..:|:...|.:|||:..:|||:....|||||.|||..|:|...|....|..|..
Mouse  1121 GYGSPKDVAVYAALGLSPSQTYIVGRAVRKLQAQCQFLSDGYVAHLGQLEAGSHSHAPSGPPRAA 1185

  Fly  1236 IPRGCFNLPGQTANPRRRSNAFELQLANISPSSSNINSPSS 1276
            :.:..:.:.......|::|..    |.:..||..:...|.:
Mouse  1186 LAKSSYAVAAPVDFLRKQSQL----LRSRGPSQVDREGPGT 1222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	175/266 (66%)
		DDHD	743..924	CDD:460725	93/200 (47%)
		LNS2	1072..1203	CDD:197870	82/130 (63%)
Pitpnm1	NP_032877.1	SRPBCC_PITPNM1-2_like	1..257	CDD:176898	175/266 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..330		21/126 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	581..679		22/98 (22%)
		DDHD	685..878	CDD:460725	94/201 (47%)
		LNS2	1022..1153	CDD:197870	82/130 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1206..1243		4/21 (19%)