DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgB and lpin-1

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	NP_506380.2	Gene:	lpin-1 / 179853	WormBaseID:	WBGene00010425	Length:	794	Species:	Caenorhabditis elegans

Alignment Length:	914	Identity:	172/914 - (18%)
Similarity:	290/914 - (31%)	Gaps:	343/914 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IIINEPYKDGPGGNGQYTKKIYHVG------------------NHLPGWIKSLLPKS--ALTVEE 86
            :::.:|       ||:|....:||.                  |.:...:|..|..|  |..|||
Worm    30 VVVEQP-------NGEYKSTPFHVRFGKYGVFSYSDKYVDIAVNGVEIDLKMKLADSGVAFFVEE 87

  Fly    87 EAWNAYPYTRTRYTCPFVEKFSLDIETYYYP-------DNGYQDNVFQLSGSDLRNRIVDVIDIV 144
            .......|.   .|.|..|:     ||   |       |....::..:|..:...|..||:.||.
Worm    88 ADDQVPDYL---LTSPLPEQ-----ET---PQTAGPAVDKVLAESARKLEETQNENEDVDMNDIA 141

  Fly   145 KDQLWGGDYVKEEDPKHFVSDKTGRGPLAEDWLEEYWREVKGKKQPTPRNMSLMTAYKICRVEFR 209
            |.:....|              .|:|...|...|:...:|: :||..|.:.|:.:       :.|
Worm   142 KSRSSSPD--------------GGQGNAREPKQEQSLSQVQ-RKQTLPFSSSVFS-------DRR 184

  Fly   210 YWGM--------QTKLEK-----------------FIHDVALRKMMLRAHRQAWAWQDEWFGLTI 249
            |..:        :|::|:                 |:|          :|.|....:.:.|..:.
Worm   185 YRSLPDLTVLAAETEVERTDIKKSDGKRTRKTPRPFVH----------SHSQCSPMEKKHFHKSN 239

  Fly   250 EDI-RELERQT-----QLALAKK-------------------MGGGEECSDDSV-SEP------- 281
            ::| |.|.|:|     ::.|.||                   ....:...|.|| |.|
Worm   240 DEILRSLRRETHDMDRRIPLRKKSRVTFNQQATRPIDIKIQQYNDSDSELDSSVNSSPSPSLVDQ 304

  Fly   282 ----YVSTAATAASTTGSERKKSAPAVPPIVT-----------------QQPPSAEAS------- 318
                .::..|.:.|....:|.::|...|..||                 :|...||.|
Worm   305 READRIADGALSDSEVDRQRDRNATPEPHDVTDWKWGELPETREQNKRKKQDEDAEKSTSRWSSW 369

  Fly   319 --------SDEEGEEEEDDDEDENDAIGTGVDLSANQGGSAQR-----SRSQSIQMAQKGKFGSK 370
                    :|||.:|:|..:::|.   |..:|...|...:...     .:..|:.....|.. |:
Worm   370 FWRSSTSTADEEQKEKEKLEQEEQ---GISLDELLNSSSNPVEIEKYLGKPPSVTSIDSGHV-SR 430

  Fly   371 GALH--SPVGSAHSFDLQSKKPHAKTAPRRHVANWRMERLEVDSKSNSDEEFFDCLDTNETNSLA 433
            |...  ||:.:...:...:..|:.||..|..|.
Worm   431 GVSQPSSPISNHDDYTPTTTPPNDKTPTRESVR-------------------------------- 463

  Fly   434 KWSSLELLGEGDDSPPPHGGPSSAASVGGRGNSRQEDSIF--NQDFL-----------MRVASER 485
                   .|.|:|.      |||.::..|..:....|.||  ::|.|           :|::||:
Worm   464 -------FGAGNDI------PSSTSATNGVRSRASSDEIFPLSEDELDDNFRPQYMQSLRLSSEK 515

  Fly   486 GNKRQLRSSASVDRSHD---SSPPGSPSTPSCPTTILI------LVVHAGSVLDAASELTAKKSD 541
                 |:|...|..:::   |.......|..|...|.:      :||   |.:|.    |..|||
Worm   516 -----LKSLGLVFGANELRFSITTKFQGTTWCSCNIYLYKWYEQIVV---SDIDG----TITKSD 568

  Fly   542 VT-----------TFRGSFEAVMRQHYPSLLTHVTIKMVPCPSICTDALGILSSLSPYSFDASPS 595
            |.           ...|..|...|      :.:...|||   .:.:.|:|...:...|....:..
Worm   569 VLGHVIPAIGGTWAHTGVAELYTR------IKNNGYKMV---YLSSRAIGQSHTTKQYLKSVAQD 624

  Fly   596 AADIPNIADVPIGAIPLLSVASPEFHETVNKTVAAANIVYHEFLKS--EEGHGF-SGQIVMLGDS 657
            :..:|   |.|:...| .|:.:....|.:.:......|.....||.  ..|:.| :|    .|:.
Worm   625 SKQLP---DGPVLLSP-TSIITAFRREVIERRPEEFKIAALTDLKQLFPSGNPFYAG----FGNR 681

  Fly   658 MGSLLAYEALCRSNGSQPGTASGASNSGGDAATNINTHNPLSPRNSRLDDDERFIEADLDAKRLL 722
            :..:::|||:.                                           :.|   |:.|:
Worm   682 ITDVVSYEAVA-------------------------------------------VPA---ARILI 700

  Fly   723 VAPSPRRRRSSSSSDSRATK-LDFEVCDFFMFGSPLSVVLA--ARKLHDAKAALPRPNCHQVYNL 784
            :.||.:.:||.||..:.:.| :..:..| :|| .||||.:.  |||.....:...:|..|..:..
Worm   701 IDPSGKVKRSDSSGLALSYKSMASDTVD-YMF-PPLSVHVKGDARKTERLTSTWSKPLEHSNFTH 763

  Fly   785 FHPT 788
            :|.|
Worm   764 WHMT 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	56/302 (19%)
		DDHD	746..924	CDD:280937	14/45 (31%)
		LNS2	1072..1203	CDD:197870
lpin-1	NP_506380.2	SMP2	1..736	CDD:227415	163/881 (19%)
lpin-1	NP_506380.2	LNS2	508..732	CDD:369773	57/300 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900