Protein Alignment rdgB and pitp-1

DIOPT Version :10

• Sequence 1: NP_001259535.1
• Gene: rdgB / 32340
• FlyBaseID: FBgn0003218
• Length: 1297
• Species: Drosophila melanogaster
• Sequence 2: NP_497726.2
• Gene: pitp-1 / 175459
• WormBaseID: WBGene00010813
• Length: 1034
• Species: Caenorhabditis elegans
• Alignment Length: 1297
• Identity: 456/1297 - (35%)
• Similarity: 653/1297 - (50%)
• Gaps: 308/1297 - (23%)

  Fly     1 MLIKEYRIPLPLTVEEYRIAQLYMIAKKSREESHGEGSGVEIIINEPYKDGPGGNGQYTKKIYHV 65
            ||||||||.||:||:||||||||||.||||.:|||:.||||||.|:||.|||||:||||.||||:
 Worm     1 MLIKEYRILLPMTVQEYRIAQLYMIQKKSRLDSHGQDSGVEIISNKPYTDGPGGSGQYTFKIYHI 65

  Fly    66 GNHLPGWIKSLLPKSALTVEEEAWNAYPYTRTRYTCPFVEKFSLDIETYYYPDNGYQDNVFQLSG 130
            |:.:|.||:::||.:||...||:|||||.|:|||:.|.:::|||::||.|:.|:|.|:|||.|:.
 Worm    66 GSRIPAWIRTVLPTNALEAHEESWNAYPVTKTRYSTPMMDRFSLEVETLYFDDHGQQENVFNLNE 130

  Fly   131 SDLRNRIVDVIDIVKDQLWGGDYVKEEDPKHFVSDKTGRGPLAEDWLEEYWREVKGKKQPTPRNM 195
            .|...||:|.:|.|||.:...||..|||||.:.|:.|.||||.:||:.|:.:          :.:
 Worm   131 KDKSTRIIDYMDFVKDPISSHDYCAEEDPKLYRSETTNRGPLNDDWVAEHLK----------KGL 185

  Fly   196 SLMTAYKICRVEFRYWGMQTKLEKFIHDVALRKMMLRAHRQAWAWQDEWFGLTIEDIRELERQTQ 260
            .:|.|||:|:||||||||||:.|::|||:|||..|:|||||||||||||.|||:.|||:||.:..
 Worm   186 PIMCAYKLCKVEFRYWGMQTRAERWIHDLALRNTMMRAHRQAWAWQDEWTGLTMNDIRKLEAEAA 250

  Fly   261 LALAKKMGGGEECSDDSVSEPYVSTAATAASTTGSERKKSAPAVPPIVTQQPPSAEASSDEEGEE 325
            |.|:|.|         ||.|                                       :|:|.:
 Worm   251 LHLSKVM---------SVKE---------------------------------------NEDGHQ 267

  Fly   326 EEDDDEDENDAIGTGVDLSANQGGSAQRSRSQSIQMAQKGKFGSKGALHSPVGSAHSFDLQSKKP 390
            :|:|.:|:.|| |..|
 Worm   268 DENDTDDDMDA-GDAV------------------------------------------------- 282

  Fly   391 HAKTAPRRHVANWRMERLEVDSKSNSDEEFFDCLDTN----ETNSLAKWSS-LELLGEGDDSPP- 449
                                     ||:.:|||.||:    :..|:.:||| |||..:.|:|||
 Worm   283 -------------------------SDDLYFDCTDTSPIPTQKPSIIRWSSELELEIQDDNSPPL 322

  Fly   450 -PHGGPSSAASVGGRGNSRQEDSIFNQDFLMRVASERGNKRQLRSSASVDRSHDSSPPGSPSTPS 513
             ||.|.:..|.:         ..:|:.||                              ||..|:
 Worm   323 TPHNGSTEVALL---------IMVFHGDF------------------------------SPDNPA 348

  Fly   514 CPTTILILVVHAGSVLDAASELTAKKSDVTTFRGSFEAVMRQHYPSLLTHVTIKMVPCPSICTDA 578
                                  .:|.:|..||..:.|..:::|||.|...:.|..|.|....|..
 Worm   349 ----------------------DSKTTDTNTFSSTIETCVQRHYPQLRNRLHIVNVSCGHEMTQV 391

  Fly   579 LGILSSLSPYSFDASPSAADIPNIADVPIGAIPLLSVASPEFHETVNKTVAAANIVYHEFLKSEE 643
            :..||::|| ||.....:..:            :|..||..::|.|..|:..||..|:||:.|:.
 Worm   392 VSKLSNISP-SFGLLHPSLSL------------MLPSASHLYNEAVEGTIRRANETYNEFIASQP 443

  Fly   644 GHGFSGQIVMLGDSMGSLLAYEALCRSNGSQPGTASGASN----------SGGDAATNI------ 692
              .|:|::.::||.:|.:..|||:.|...|.......:||          |...:.|:|
 Worm   444 --LFNGEVFVVGDCVGGIFLYEAMTRKCDSMTLLKRLSSNLSSRIIKEDQSPHQSMTDITITDTS 506

  Fly   693 ------NTHNPLSPRNSRLDDDERFIEADLDAKRLLVAPSP---RRRRSSSSSDS---RATKLDF 745
                  ..||.....:|.|.:..   .:...|:.....||.   |::.|..|.||   .|::|.|
 Worm   507 SISSCPQQHNQSVRDHSSLQNGH---ASRRSARNYSAPPSASYVRKKISLVSVDSVSFGASRLSF 568

  Fly   746 EVCDFFMFGSPLSVVLAARKLHDAKAALPRPNCHQVYNLFHPTDPIASRLEPLLSARFSILAPVN 810
            :....|:.|.||.:.|..||| |........:| |::||::|.||..:|:||:|..:.|.:.|.|
 Worm   569 QPSTVFLLGCPLGLTLMQRKL-DGSEIDGLDSC-QLFNLYYPLDPCGARIEPVLDGQLSCVPPYN 631

  Fly   811 VPRYAKYPLGNGQPLHLLEVIQSHPQHFNDGNNLLAGRRLSDASMQSTISGLIENVSLSTIHALQ 875
            ||:|.:||||:|:           .|.|.                             |||.|.|
 Worm   632 VPKYQRYPLGDGK-----------SQKFE-----------------------------STIDATQ 656

  Fly   876 NKWWGTKRLDYALYCPEGLSNFPAHALPHLFHASYWESPDVIAFILRQIGKFEGIPFVGS-NDDK 939
              .||:||:|..||||..:...|:.|||::.|||||||.||.:|:|||..:.|....:.: :...
 Worm   657 --MWGSKRIDNLLYCPNSMVALPSSALPNILHASYWESCDVASFLLRQFVRGEENSVLTTLSSSM 719

  Fly   940 DNASFHPGQPREKWIKKRTSVKLKNVAANHRANDVIVQEGREQRLNARFMYGPLDMITLHGEKVD 1004
            :|...:...|...|.:|||..|:.|::|||||||::|..|.:..:.|:|.|||:|::.|..|.|.
 Worm   720 NNIPLNIDLPTMHWKRKRTRFKIANLSANHRANDILVTAGMDLTVIAKFCYGPMDLVALSREPVS 784

  Fly  1005 VHIMKDPPAGEWTFLSTEVTDKNGRISYSIPDQVSLGYGIYPVKMVVRGDHTSVDCYMAVVPPLT 1069
            |.:.  |..|:|.......||.:||::..:..  :|..||:.||:||.||.:.:|.::|:||..|
 Worm   785 VFVY--PQRGDWYLHGVFDTDSHGRLTLQLAK--TLPCGIHSVKIVVHGDRSYLDAFVAIVPHGT 845

  Fly  1070 ECVVFSIDGSFTASMSVTGRDPKVRAGAVDVCRHWQELGYLLIYITGRPDMQQQRVVSWLSQHNF 1134
            :|.|||:|||.|||:||||:||:||.|||||.|:|||.|||:||:|.||||||:.|.:||:||||
 Worm   846 KCAVFSVDGSLTASVSVTGKDPRVRPGAVDVVRYWQEQGYLIIYLTARPDMQQRVVSAWLAQHNF 910

  Fly  1135 PHGLISFADGLSTDPLGHKTAYLNNLVQNHGISITAAYGSSKDISVYTNVGMRTDQIFIVGKVGK 1199
            ||.|:.|.:..||:||..|:.:|.::| :.|:.|..||||.||::|||:.|:  |...::...|.
 Worm   911 PHALLFFNNSFSTEPLKQKSLHLRHIV-DMGVHIHVAYGSGKDVNVYTSAGV--DPEHVISVAGS 972

  Fly  1200 KLQSNATVLSDGYAAHLAGL---QAVGGSRPAKGNARMVIPRGCFNLPGQTANPRRRSNAFE 1258
            :.::  .|..:.|::|||.|   |...|.|.......:.:.|.....|..|.    |...||
 Worm   973 RRRN--CVQIESYSSHLAALNSGQCTLGKRIEDDGLTLQLHRNVQRTPSFTP----RGGKFE 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	155/266 (58%)
		DDHD	743..924	CDD:460725	65/180 (36%)
		LNS2	1072..1203	CDD:197870	70/130 (54%)
pitp-1	NP_497726.2	SRPBCC_PITPNM1-2_like	1..258	CDD:176898	156/275 (57%)
		DDHD	566..>640	CDD:460725	29/75 (39%)
		Haloacid Dehalogenase-like Hydrolases	849..975	CDD:473868	70/128 (55%)