DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgB and Lpin1

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	XP_006515038.1	Gene:	Lpin1 / 14245	MGIID:	1891340	Length:	1010	Species:	Mus musculus

Alignment Length:	1233	Identity:	224/1233 - (18%)
Similarity:	367/1233 - (29%)	Gaps:	408/1233 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 PGWIKSLLPKSA----------------LTVEEEAWNAYPYTRTRYTCPFVEKFSLDIETYYYPD 118
            ||||:|:.|.:.                :||:|......|.|.:  .|       :||.....|:
Mouse    45 PGWIRSVWPSNINVQTMNYVGQLAGQVFVTVKELYKGLNPATLS--GC-------IDIIVIRQPN 100

  Fly   119 NGYQDNVFQLSGSDL-----RNRIVDV------IDIVKDQLWGGD-----YVKEED-PKHFVSDK 166
            ...|.:.|.:....:     |.::||:      :|:   .:..||     :|:|.| .:..:...
Mouse   101 GSLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDL---HMKLGDNGEAFFVQETDNDQEIIPMY 162

  Fly   167 TGRGPLAEDWLEEYWREVKGKKQPTPRNMSLMTAYKICRVEFRYWGMQTKLEKFIHDVALRKMML 231
            ....|:..:.......::|.......|.:...||.:
Mouse   163 LATSPILSEGAARMESQLKRNSVDRIRCLDPTTAAQ----------------------------- 198

  Fly   232 RAHRQAWAWQDEWFGLTIEDI----------RELERQTQLALAKKMGGGEECSDDSVSEPYVSTA 286
                          ||...|.          |:..|:.||...|:........|:.:....:|:.
Mouse   199 --------------GLPPSDTPSTGSLGKKRRKRRRKAQLDNLKRDDNVNTSEDEDMFPIEMSSD 249

  Fly   287 ATAASTTGSERKKSAP-AVPPIVTQQPPSAEASSDEEGEEEEDDDEDEN-DAIGTGVDLSANQGG 349
            ...|...||   ::.| .|||.                   :||...|| .:|.|....::....
Mouse   250 EDTAPMDGS---RTLPNDVPPF-------------------QDDIPKENFPSISTYPQSASYPSS 292

  Fly   350 SAQRSRSQS--IQMAQKGKFGSKGALHSPVGSAHSFDLQSKKPHAKTAPRRHVANWRMERLEVDS 412
            ..:.|.|.|  :...:.....::|.|.|      |..|||...||..:|..          ...|
Mouse   293 DREWSPSPSSLVDCQRTPPHLAEGVLSS------SCPLQSCHFHASESPSG----------SRPS 341

  Fly   413 KSNSDEEFFDCLDTNETNSLAKWSSLELLGEGDDSPPPHGGPSSAASVGGRGNSRQEDSIFNQDF 477
            ...||.|    |.:...:.|...::||:|....:.|
Mouse   342 TPKSDSE----LVSKSADRLTPKNNLEMLWLWGELP----------------------------- 373

  Fly   478 LMRVASERGNKRQLRSSASVDRSHDSSPPGSPSTPSCPTTILILVVHAGSVLDAASELTAKKSDV 542
                        |...|:|..:..:|||.||..||.   .:....:|:.|            ||
Mouse   374 ------------QAAKSSSPHKMKESSPLGSRKTPD---KMNFQAIHSES------------SD- 410

  Fly   543 TTFRGSFEAVMRQHYPSLLTHVTIKMVPCPSICTDALGILSSLSPYSFDASPSAADIPNIADVPI 607
             ||......:.|    .||.|.:........:..:.|..|.:.:|.|..|....|..||.|
Mouse   411 -TFSDQSPTMAR----GLLIHQSKAQTEMQFVNEEDLESLGAAAPPSPVAEELKAPYPNTA---- 466

  Fly   608 GAIPLLSVASPEFHETVNKTVAAANIVYHEFLKSEEGHGFSGQIVMLGDSMGSLLAYEAL-CRSN 671
                          ::.:||.:.:.      .|.:.........|.|.|.........|| ...|
Mouse   467 --------------QSSSKTDSPSR------KKDKRSRHLGADGVYLDDLTDMDPEVAALYFPKN 511

  Fly   672 GSQPGTASGASNSGGDAATNINTHNPLSPRNSRLDDDERFIEADLDAKRLLVAPSPRRRRSSSSS 736
            |...|....||::|..:|    ..:|.|...|.:|..   :|:..|:.|.|  ||.........|
Mouse   512 GDPGGLPKQASDNGARSA----NQSPQSVGGSGIDSG---VESTSDSLRDL--PSIAISLCGGLS 567

  Fly   737 DSR-ATKLDFEVCDFFMFGSPLSVVLAARKLHDAKAALPRPNC-----HQVYNLFHPTDPIASRL 795
            |.| .||      |.|     |...::.::..|..|.:..||.     ::.||.        :..
Mouse   568 DHREITK------DAF-----LEQAVSYQQFADNPAIIDDPNLVVKVGNKYYNW--------TTA 613

  Fly   796 EPLLSARFSILAPVNVPRYAKYPLGNGQPLH-LLEVIQSHPQHFNDGNNLLAGRRLSDASMQSTI 859
            .|||.|..:...|:.......|       || :|:.|                 |...:.:.|..
Mouse   614 APLLLAMQAFQKPLPKSSCLSY-------LHGILDAI-----------------RFCLSKIFSPP 654

  Fly   860 SGLIENVSLSTIHALQNKWWGTKRLDYALYCPEGLSNFPAHALPHLFHASYWESPDVIAFILRQI 924
            :..:|::....:.....:||.:.|...|....|   :.|...|....| :..|.|       .|:
Mouse   655 TATVESIMRDKMPKKGGRWWFSWRGRNATIKEE---SKPEQCLTGKGH-NTGEQP-------AQL 708

  Fly   925 GKFEGIPFVGSNDDKDNASFHPGQPRE---------KWIKKRTSVKLKNVAANHRANDVIVQEGR 980
            |....|....|:.|:::|:..|.....         |...:.||.:||::...:..|||:.....
Mouse   709 GLATRIKHESSSSDEEHAAAKPSGSSHLSLLSNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTT 773

  Fly   981 EQRLNARFMYGPLDMITLHGEKVDVHIMKDPPAGEWTFLSTEVTDKNGRISYSIPDQVSLGYGIY 1045
            :.:...|.                          |.|.......||
Mouse   774 QYQGTCRC--------------------------EGTIYLWNWDDK------------------- 793

  Fly  1046 PVKMVVRGDHTSVDCYMAVVPPLTECVVFSIDGSFTAS------MSVTGRDPKVRAGAVDVCRHW 1104
                                     .::..|||:.|.|      :...|:| ....|...:....
Mouse   794 -------------------------VIISDIDGTITRSDTLGHILPTLGKD-WTHQGIAKLYHKV 832

  Fly  1105 QELGYLLIYIT----GRPDMQQQRVVSWLSQHN--FPHGLI-----SFADGLSTDPLGHK----- 1153
            .:.||..:|.:    |..|| .:..:.|:::..  .|.|.:     |....|..:.:..|
Mouse   833 SQNGYKFLYCSARAIGMADM-TRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFK 896

  Fly  1154 ---TAYLNNLVQNHGISITAAYGS-SKDISVYTNVGMRTDQIFIVGKVGKKLQSNATVLSDGY 1212
               ...:.||...:.....||:|: ..|:..|..||:..::||.|...|:.:|.:|......|
Mouse   897 VQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSY 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	39/240 (16%)
		DDHD	746..924	CDD:280937	32/183 (17%)
		LNS2	1072..1203	CDD:197870	33/156 (21%)
Lpin1	XP_006515038.1	Lipin_N	61..166	CDD:368000	20/116 (17%)
		Spc7_N	<237..429	CDD:373822	58/295 (20%)
		Lipin_mid	558..>631	CDD:374860	19/91 (21%)
		LNS2	746..971	CDD:369773	48/286 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900