DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdgB and pitpnm3

DIOPT Version :9

Sequence 1:	NP_001259535.1	Gene:	rdgB / 32340	FlyBaseID:	FBgn0003218	Length:	1297	Species:	Drosophila melanogaster
Sequence 2:	XP_031752634.1	Gene:	pitpnm3 / 100495900	XenbaseID:	XB-GENE-983510	Length:	959	Species:	Xenopus tropicalis

Alignment Length:	997	Identity:	410/997 - (41%)
Similarity:	576/997 - (57%)	Gaps:	127/997 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 SKKPHAKTAPRRHVANWRMERLEVDSKSNSDEEFFDCL-DTNETNS-----LAKWSS------LE 439
            ::.|....:.|...|.|.::::..||..:||:||||.. :..|..|     :::|:|      :|
Frog     2 AQAPQTGGSRRFSGAQWHLQKIINDSVDSSDDEFFDAREEVVEGKSAILIGMSQWNSNDLVEQIE 66

  Fly   440 LLGEGDDSPPPHGGPSSAASVGGRGNSRQEDSIFNQDFLMRVASERGNKRQLRSSASVDRSHDSS 504
            .:|:.:::|..                           |.||   .|.|.:....:|.:...||.
Frog    67 TIGKMEENPGE---------------------------LYRV---HGRKHRCPRQSSFEIQEDSE 101

  Fly   505 PPGSPSTPSCPTTILILVVHAGSVLD-AASELTAKKSDVTTFRGSFEAVMRQHYPSLLTHVTIKM 568
              .:....||.|.:|.||:|.||:|| ...::.:|.:||.||...||.|.|.|:|:.|.|:.|::
Frog   102 --DAMQENSCKTQVLALVLHGGSILDTGGGDINSKLADVNTFSSVFEKVTRAHFPAALGHILIRL 164

  Fly   569 VPCPSICTDALGILSSLSPYSFDASPSAADIPNIAD--VPIGAIPLLSVASPEFHETVNKTVAAA 631
            ||||:||::|..::.:|:|||:|     .:..||::  :|:.|:|||:::||::.:.|...:..|
Frog   165 VPCPAICSEAFSLVYNLNPYSYD-----ENCLNISEDHIPLAALPLLAISSPQYQDAVAMVINRA 224

  Fly   632 NIVYHEFLKSEEGHGFSGQIVMLGDSMGSLLAYEALCRSNGSQPGTASGASNSGGDAATNINTHN 696
            |.||:|||||.:|..|:||:.::||.:|.:|.::|||.| |..||.:..:|..|..::...|: .
Frog   225 NQVYNEFLKSPDGASFNGQVCLIGDCVGGILGFDALCYS-GKTPGESQNSSRRGSCSSIQDNS-T 287

  Fly   697 PLSPRNSRLDDDERFIEADLDAKRLLVAPSPR----RRRSSSSSDSRAT---------------- 741
            |....::.|...:|..::::|...:|...:|:    |::|.||:....|
Frog   288 PPEDNSAGLRGTKRLSKSNIDISGVLDNGAPKQPLLRKQSDSSTYDCDTITQHHAFLSSIHSSVL 352

  Fly   742 --------------------KLDFEVCDFFMFGSPLSVVLAARK--LHDAKAALPRPNCHQVYNL 784
                                :.||||.|||:|||||.:|||.|:  |....|....|.|.|||:.
Frog   353 KDDMDFPRTGSSNLCEVIMGRFDFEVSDFFLFGSPLGLVLAMRRTVLPGLDACRAHPACSQVYSF 417

  Fly   785 FHPTDPIASRLEPLLSARFSILAPVNVPRYAKYPLGNGQPLHLLEVIQSHPQHF---NDGNNLLA 846
            ||..||.||||||||...|.:|.|.|||||.|.|||:|:...|::.||:....|   ...||..:
Frog   418 FHSADPSASRLEPLLEKSFHMLPPFNVPRYQKNPLGDGKSYLLVDAIQACSAAFVEQGTPNNTAS 482

  Fly   847 ----------------GRRLSDASMQSTISGLIENVSLSTIHALQNKWWGTKRLDYALYCPEGLS 895
                            .||.|..||.|.:||..|::..:.|..:...|||:||:|||||||:.|:
Frog   483 ADTSPLASLSTPTQRKARRSSLVSMSSEMSGSSESLPSAKIANITANWWGSKRIDYALYCPDVLT 547

  Fly   896 NFPAHALPHLFHASYWESPDVIAFILRQIGKFEGIPFVGSNDDKDNASFHPGQPREKWIKKRTSV 960
            .||..|||||||||||||.||:||||||:.::|.:. :...:..|..:..|...:|||::||..|
Frog   548 AFPTVALPHLFHASYWESTDVVAFILRQLMRYESVQ-IQQKEGIDCMNMSPSSRQEKWLRKRNHV 611

  Fly   961 KLKNVAANHRANDVIVQEGREQRLNARFMYGPLDMITLHGEKVDVHIMKDPPAGEWTFLSTEVTD 1025
            ||:||.|||||||||..||..|.|..|||||||||:.|.||||||.||.:|.:|.|.:..||:::
Frog   612 KLRNVTANHRANDVIAVEGGPQVLVGRFMYGPLDMVALTGEKVDVLIMTEPSSGRWVYFETEISN 676

  Fly  1026 KNGRISYSIPDQVSLGYGIYPVKMVVRGDHTSVDCYMAVVPPLTECVVFSIDGSFTASMSVTGRD 1090
            .:||:|||:|....||.|:||:|||||||.:|...|:.|:||..|||||||||||.||:|:.|.|
Frog   677 SSGRVSYSVPKDKRLGVGVYPIKMVVRGDQSSAQSYLTVLPPGMECVVFSIDGSFAASVSIMGSD 741

  Fly  1091 PKVRAGAVDVCRHWQELGYLLIYITGRPDMQQQRVVSWLSQHNFPHGLISFADGLSTDPLGHKTA 1155
            ||||||||||.||||:||:|:||||||||||:|||||||||||||.|:|.|:|||..|||..||.
Frog   742 PKVRAGAVDVVRHWQDLGFLIIYITGRPDMQKQRVVSWLSQHNFPQGMIFFSDGLVHDPLRQKTI 806

  Fly  1156 YLNNLVQNHGISITAAYGSSKDISVYTNVGMRTDQIFIVGKVGKKLQSNATVLSDGYAAHLAGLQ 1220
            :|.||:|...|.|:|||||.||||||:.:|:...||:|||:..||.|:....:|||||||||.|:
Frog   807 FLRNLMQECHIKISAAYGSMKDISVYSVLGLSPPQIYIVGRPAKKYQNQCQFVSDGYAAHLASLE 871

  Fly  1221 AVGGSRPAKGNARMVIPRGCFNLPGQTANPRRRSNAFE-LQLANISPSSSN------INSPSSG- 1277
            ....|||.|.|:||::.:|.|.|..|....|:|::... :.:....|.|:|      .:.|.|.
Frog   872 FSHHSRPKKNNSRMILRKGSFGLHTQPEFLRKRNHLRRTMSVQQPEPPSTNPKPERAQSQPESDK 936

  Fly  1278 ---NHILLAQLIENAIEKDTPA 1296
               .|:.....:.||..|..|:
Frog   937 DHERHLNPLSWVRNASHKFEPS 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898
		DDHD	746..924	CDD:280937	97/198 (49%)
		LNS2	1072..1203	CDD:197870	90/130 (69%)
pitpnm3	XP_031752634.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	406	1.000	Domainoid score	I697
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	711	1.000	Inparanoid score	I638
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122895at2759
OrthoFinder	1	1.000	-	-		FOG0002342
OrthoInspector	1	1.000	-	-		oto103903
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.970