DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXD8 and ftz

DIOPT Version :9

Sequence 1:	NP_062458.1	Gene:	HOXD8 / 3234	HGNCID:	5139	Length:	290	Species:	Homo sapiens
Sequence 2:	NP_477498.1	Gene:	ftz / 40834	FlyBaseID:	FBgn0001077	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	302	Identity:	82/302 - (27%)
Similarity:	112/302 - (37%)	Gaps:	115/302 - (38%)

- Green bases have known domain annotations that are detailed below.

Human    71 HPHPSPPP----SGTGCGGREGRGQEYFHPGGGSPAAAY----------QAAPPPPPHPPPPPPP 121
            |||..||.    ||:....:.....:.::|......:.|          |..||..|..|||...
  Fly    23 HPHSLPPTYYDNSGSNAYYQNTSNYQGYYPQESYSESCYYYNNQEQVTTQTVPPVQPTTPPPKAT 87

Human   122 P-----------------PCGGIACHGEPAKFYGY---------DNLQRQPIFTTQQEA------ 154
            .                 |....|....|.|...|         :.:::.|..:|:..|
  Fly    88 KRKAEDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTVEQVKKAPAVSTKVTASPAPSY 152

Human   155 --ELVQYPDCKSSSGNIGEDPDHLNQSSSPSQ------------------MFPWMR----PQAAP 195
              |.|..|...:|     ||.|:|:..|..||                  ..|.:.    |..:|
  Fly   153 DQEYVTVPTPSAS-----EDVDYLDVYSPQSQTQKLKNGDFATPPPTTPTSLPPLEGISTPPQSP 212

Human   196 GR----------------------------------------RRGRQTYSRFQTLELEKEFLFNP 220
            |.                                        :|.||||:|:|||||||||.||.
  Fly   213 GEKSSSAVSQEINHRIVTAPNGAGDFNWSHIEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNR 277

Human   221 YLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKENNKDKFP 262
            |:||:|||::::||:|:|||:||||||||||.||:...|..|
  Fly   278 YITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDRTLDSSP 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXD8	NP_062458.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..127		17/86 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..200		12/100 (12%)
		Homeobox	201..253	CDD:278475	38/51 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..290		2/8 (25%)
ftz	NP_477498.1	FTZ	1..248	CDD:281812	39/229 (17%)
ftz	NP_477498.1	Homeobox	257..310	CDD:278475	38/52 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810