DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Yp3 and PNLIP

DIOPT Version :9

Sequence 1:	NP_001285228.1	Gene:	Yp3 / 32339	FlyBaseID:	FBgn0004047	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_000927.1	Gene:	PNLIP / 5406	HGNCID:	9155	Length:	465	Species:	Homo sapiens

Alignment Length:	391	Identity:	94/391 - (24%)
Similarity:	141/391 - (36%)	Gaps:	133/391 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLVAAHASKDASNDRLKPTKWLTATELENVPSLNDITWERLENQPLEQGAKVIEKIYHVGQIKHD 77
            ||:.|.|.|:...:||....             :|..|..:..:||           |:
Human     9 LLLGAVAGKEVCYERLGCFS-------------DDSPWSGITERPL-----------HI------ 43

  Fly    78 LTPSFVP-SPSNVPV-WIIKSNGQKVECKLNNYVETAKAQPGFGEDEVTIVLTGLPKTSPAQQKA 140
                 :| ||.:|.. :::.:|...     ||:.|.|       .|..:|..:.. ||:    :.
Human    44 -----LPWSPKDVNTRFLLYTNENP-----NNFQEVA-------ADSSSISGSNF-KTN----RK 86

  Fly   141 MRRLIQAYVQKYN---LQQLQKNAQEQQQQLKSSDYDYTSSEEAADQWKSAKAASGDLIIID-LG 201
            .|.:|..::.|..   |..:.||.                          .|..|.:.|.:| .|
Human    87 TRFIIHGFIDKGEENWLANVCKNL--------------------------FKVESVNCICVDWKG 125

  Fly   202 STLTNFKRYAMLDVLNTGAMIGQTLIDLTNK-GVPQEIIHLIGQGISAHVAGAAGNKYTAQTGHK 265
            .:.|.:.: |..::...||.:...:..|.:. |.....:|:||..:.||.||.||.:    |...
Human   126 GSRTGYTQ-ASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRR----TNGT 185

  Fly   266 LRRITGLDPAKVLSKRPQILGGLSRGDADFVDAIHTSTFAMGTPI----------RCGDVDFYPN 320
            :.||||||||:...:....|..|...||.|||.|||.    |.||          ..|.:||:||
Human   186 IGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTD----GAPIVPNLGFGMSQVVGHLDFFPN 246

  Fly   321 GPSTGVPG-SENV------IEAVARATRYFAESVRPGSERNFPAVPANSLKQYK-------EQDG 371
            | ...:|| .:|:      |:.:...||.||              ..|.|:.||       ..||
Human   247 G-GVEMPGCKKNILSQIVDIDGIWEGTRDFA--------------ACNHLRSYKYYTDSIVNPDG 296

  Fly   372 F 372
            |
Human   297 F 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Yp3	NP_001285228.1	Lipase	93..400	CDD:278576	78/309 (25%)
Yp3	NP_001285228.1	Abhydrolase	<215..396	CDD:304388	56/183 (31%)
PNLIP	NP_000927.1	Lipase	17..352	CDD:278576	90/383 (23%)
PNLIP	NP_000927.1	PLAT_PL	355..465	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145213
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840