DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rtc1 and RCL1

DIOPT Version :9

Sequence 1:	NP_572919.1	Gene:	Rtc1 / 32338	FlyBaseID:	FBgn0020909	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_014633.1	Gene:	RCL1 / 854152	SGDID:	S000005370	Length:	367	Species:	Saccharomyces cerevisiae

Alignment Length:	383	Identity:	123/383 - (32%)
Similarity:	213/383 - (55%)	Gaps:	39/383 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YRGSNFLKQRLILACLSGKPVKISQIRSEDETAPGLREYEISLIRLLDKITNGTKIELNPAGTSV 77
            ::||...:.|::||.|||||:||.:|||.| ..|||::||:|.:||::.:|||:.||::..||:|
Yeast    11 FQGSQNFRLRIVLATLSGKPIKIEKIRSGD-LNPGLKDYEVSFLRLIESVTNGSVIEISYTGTTV 74

  Fly    78 MFSPGLLHGGQLNHDCCVQRGIGYYLDALIALGPFCKSPLQCTLRGVTNSKDSPSVDHIKGAALS 142
            ::.||::.||...|.|...:.:||:::.::.|.||.|.......:|:|.|.:...::.||...:.
Yeast    75 IYRPGIIVGGASTHICPSSKPVGYFVEPMLYLAPFSKKKFSILFKGITASHNDAGIEAIKWGLMP 139

  Fly   143 LLKRFLLVDEGLE---LKVVRRGVAPLGGGEI------IFRCPVRKSLRAIQFQSQGMVKRIRGT 198
            ::::|     |:.   |..::||..||||||:      :...|:  ::..|   .:.::..|.|.
Yeast   140 VMEKF-----GVRECALHTLKRGSPPLGGGEVHLVVDSLIAQPI--TMHEI---DRPIISSITGV 194

  Fly   199 VYACKVSPAMANRTVEAAKGCMLKFLPDVYIYTDQNKGKMSGNSPGFGICLIAETTD-GVCFAAD 262
            .|:.:|||::.||.::.||..:.....:|.|..|..:|:.||.|||:||.|:|::.. |..:.|
Yeast   195 AYSTRVSPSLVNRMIDGAKKVLKNLQCEVNITADVWRGENSGKSPGWGITLVAQSKQKGWSYFA- 258

  Fly   263 CCSNTREESEDTPSIPENLGKEVALRLLDEIYRGGCVDSSYQWLAALYIALGQKHVSKFLTGALS 327
                  |:..|..||||.||::||.:||:||.:...|..:...||.:|:.:|::.:.:..... .
Yeast   259 ------EDIGDAGSIPEELGEKVACQLLEEISKSAAVGRNQLPLAIVYMVIGKEDIGRLRINK-E 316

  Fly   328 NYTVHFLQHLRDFFSITFKLENPEA--EDEDEAENVRGAQKVLMACVGIGYTNINKRV 383
            .....|:..|||.    .|:.|.|.  :..|||:|    :.::....|||:||.:|::
Yeast   317 QIDERFIILLRDI----KKIFNTEVFLKPVDEADN----EDMIATIKGIGFTNTSKKI 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtc1	NP_572919.1	RNA_Cyclase_Class_I	7..349	CDD:238447	111/345 (32%)
Rtc1	NP_572919.1	18S_RNA_Rcl1p	11..384	CDD:274564	123/383 (32%)
RCL1	NP_014633.1	18S_RNA_Rcl1p	10..367	CDD:274564	123/383 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341444
Domainoid	1	1.000	186	1.000	Domainoid score	I660
eggNOG	1	0.900	-	-		E1_COG0430
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4217
Inparanoid	1	1.050	196	1.000	Inparanoid score	I878
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53579
OrthoFinder	1	1.000	-	-		FOG0004680
OrthoInspector	1	1.000	-	-		oto100214
orthoMCL	1	0.900	-	-		OOG6_102522
Panther	1	1.100	-	-	LDO	PTHR11096
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1075
SonicParanoid	1	1.000	-	-		X3288
TreeFam	1	0.960	-	-
	15	14.790