DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rtc1 and ZK1127.5

DIOPT Version :9

Sequence 1:	NP_572919.1	Gene:	Rtc1 / 32338	FlyBaseID:	FBgn0020909	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_495445.2	Gene:	ZK1127.5 / 174151	WormBaseID:	WBGene00022852	Length:	379	Species:	Caenorhabditis elegans

Alignment Length:	376	Identity:	168/376 - (44%)
Similarity:	246/376 - (65%)	Gaps:	4/376 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LIYRGSNFLKQRLILACLSGKPVKISQIRSEDETAPGLREYEISLIRLLDKITNGTKIELNPAGT 75
            |.:.|.||.:.||..:.|||:|::|..||..|: .||:|::|..||.||:|:|||||:|::..||
Worm     6 LEFSGCNFFRIRLAYSILSGRPIRIINIRKNDD-RPGIRDFESKLIGLLEKVTNGTKVEISRTGT 69

  Fly    76 SVMFSPGLLHGGQLNHDCCVQRGIGYYLDALIALGPFCKSPLQCTLRGVTNSKDSPSVDHIKGAA 140
            .|:|.||::.||.:|.||..:|.|.|:|:.|:.|.||||.|:...|:||||:....|||.:|.:.
Worm    70 QVIFRPGMITGGVVNLDCGTERCISYFLEPLLLLSPFCKVPMVIKLKGVTNAPGEISVDGMKASW 134

  Fly   141 LSLLKRFLLVDEGLELKVVRRGVAPLGGGEIIFRCPVRKSLRAIQFQSQGMVKRIRGTVYACKVS 205
            |.:..:|:|.||.|::|:..||:.|.|||.::|..|:.|:||.::.|..|.|.:|||..|..||:
Worm   135 LKVYNKFVLNDEKLDIKIQARGLKPEGGGVVVFTAPIVKTLRPVKRQQVGKVCKIRGQAYVTKVT 199

  Fly   206 PAMANRTVEAAKGCMLKFLPDVYIYTDQNKGKMSGNSPGFGICLIAETTDGVCFAADCCSNTREE 270
            |::|.|.::|||..|..::.||||..||.||...|.|||:|:.|.||||:||.:.|:..|..:.|
Worm   200 PSLAYRMIDAAKKAMHGYISDVYITVDQRKGDAGGASPGYGLFLTAETTEGVIYQAEAISRPKGE 264

  Fly   271 SEDTPSIPENLGKEVALRLLDEIYRGGCVDSSYQWLAALYIALGQKHVSKFLTGALSNYTVHFLQ 335
            | ..|.:||::|.|....||.:||.||.:|||.|.||:.::.|..|.||.||.|.|..|:||.|:
Worm   265 S-GVPILPEDIGIEAGHALLQQIYMGGALDSSAQILASTFMTLCPKDVSHFLYGPLPMYSVHALR 328

  Fly   336 HLRDFFSITFKLEN-PEAEDEDEAENVRG-AQKVLMACVGIGYTNINKRVI 384
            ||:.||.|.||:|: .:...|:||:...| |.|.::..||:||:|:||.::
Worm   329 HLKQFFEIEFKMEDFKKTLKEEEADLKTGSADKAMVTAVGVGYSNLNKTIL 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtc1	NP_572919.1	RNA_Cyclase_Class_I	7..349	CDD:238447	154/337 (46%)
Rtc1	NP_572919.1	18S_RNA_Rcl1p	11..384	CDD:274564	168/374 (45%)
ZK1127.5	NP_495445.2	RNA_Cyclase_Class_I	2..342	CDD:238447	154/337 (46%)
ZK1127.5	NP_495445.2	18S_RNA_Rcl1p	6..378	CDD:274564	168/373 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156336
Domainoid	1	1.000	299	1.000	Domainoid score	I775
eggNOG	1	0.900	-	-		E1_COG0430
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4217
Inparanoid	1	1.050	323	1.000	Inparanoid score	I1474
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53579
OrthoDB	1	1.010	-	-		D1423847at2759
OrthoFinder	1	1.000	-	-		FOG0004680
OrthoInspector	1	1.000	-	-		oto19311
orthoMCL	1	0.900	-	-		OOG6_102522
Panther	1	1.100	-	-	LDO	PTHR11096
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1075
SonicParanoid	1	1.000	-	-		X3288
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840