DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rtc1 and RCL1

DIOPT Version :9

Sequence 1:	NP_572919.1	Gene:	Rtc1 / 32338	FlyBaseID:	FBgn0020909	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_005763.3	Gene:	RCL1 / 10171	HGNCID:	17687	Length:	373	Species:	Homo sapiens

Alignment Length:	378	Identity:	204/378 - (53%)
Similarity:	269/378 - (71%)	Gaps:	8/378 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IAQEGNCLIYRGSNFLKQRLILACLSGKPVKISQIRSEDETAPGLREYEISLIRLLDKITNGTKI 68
            :|.:.:.|.|.|.|||:|||:|:.|||:||||.:||:.|:. ||||::|.|.||||||||||::|
Human     1 MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRKIRARDDN-PGLRDFEASFIRLLDKITNGSRI 64

  Fly    69 ELNPAGTSVMFSPGLLHGGQLNHDCCVQRGIGYYLDALIALGPFCKSPLQCTLRGVTNSKDSPSV 133
            |:|..||::.:.||||:||.:.|||.|.|||||||::|:.|.||.|.||:..||||||.:..|||
Human    65 EINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLESLLCLAPFMKHPLKIVLRGVTNDQVDPSV 129

  Fly   134 DHIKGAALSLLKRFLLVDEGLELKVVRRGVAPLGGGEIIFRCPVRKSLRAIQFQSQGMVKRIRGT 198
            |.:|..||.|||:|.:..|..|||:||||:.|.||||::|.|||||.|:.||....|.:|||||.
Human   130 DVLKATALPLLKQFGIDGESFELKIVRRGMPPGGGGEVVFSCPVRKVLKPIQLTDPGKIKRIRGM 194

  Fly   199 VYACKVSPAMANRTVEAAKGCMLKFLPDVYIYTDQNKGKMSGNSPGFGICLIAETTDGVCFAADC 263
            .|:.:|||.||||.|::|:..:.||:||:|||||..||..||.|||||:.|:||||.|...:|:.
Human   195 AYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVNSGKSPGFGLSLVAETTSGTFLSAEL 259

  Fly   264 CSNTREESEDTPSIPENLGKEVALRLLDEIYRGGCVDSSYQWLAALYIALGQKHVSKFLTGALSN 328
            .||  .:.:....:||:||:..|..||:||||||||||:.|.||.|.:.|||:.|||.|.|.||.
Human   260 ASN--PQGQGAAVLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSP 322

  Fly   329 YTVHFLQHLRDFFSITFKLENPEAEDEDEAENVRGAQKVLMACVGIGYTNINK 381
            ||:.||:||:.||.|.||:|....     .|.::|..||||.|||||::|::|
Human   323 YTIEFLRHLKSFFQIMFKIETKPC-----GEELKGGDKVLMTCVGIGFSNLSK 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtc1	NP_572919.1	RNA_Cyclase_Class_I	7..349	CDD:238447	189/341 (55%)
Rtc1	NP_572919.1	18S_RNA_Rcl1p	11..384	CDD:274564	203/371 (55%)
RCL1	NP_005763.3	18S_RNA_Rcl1p	8..371	CDD:274564	203/371 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141340
Domainoid	1	1.000	379	1.000	Domainoid score	I857
eggNOG	1	0.900	-	-		E1_COG0430
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4217
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1881
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53579
OrthoDB	1	1.010	-	-		D1423847at2759
OrthoFinder	1	1.000	-	-		FOG0004680
OrthoInspector	1	1.000	-	-		oto91404
orthoMCL	1	0.900	-	-		OOG6_102522
Panther	1	1.100	-	-	LDO	PTHR11096
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1075
SonicParanoid	1	1.000	-	-		X3288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800