Protein Alignment Pdcd4 and Pdcd4

DIOPT Version :9

• Sequence 1: NP_001096977.1
• Gene: Pdcd4 / 32337
• FlyBaseID: FBgn0030520
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_071601.2
• Gene: Pdcd4 / 64031
• RGDID: 620816
• Length: 469
• Species: Rattus norvegicus
• Alignment Length: 533
• Identity: 203/533 - (38%)
• Similarity: 291/533 - (54%)
• Gaps: 92/533 - (17%)

  Fly     1 MEVESNNKRATNGGRHFTPPSDSDSKESSV-----ERELNEEIEAVELNGSGGGGHSNGHVKKLM 60
            |:||  |::..|     ..|:|.|:...|:     |....|||:          ...||:.....
  Rat     1 MDVE--NEQILN-----VNPTDPDNLSDSLFSGDEENAGTEEIK----------NEINGNWISAS 48

  Fly    61 AVEDGRIKRKAKRLIQR---QNSGSGGSANQTNGNGAAGAGGAHGASVMPLGINRIMPSPGGYVV 122
            .:.:.||..||||.:::   ::||.|.|.:. ||:.|..:|.|            :..||.|.::
  Rat    49 TINEARINAKAKRRLRKNSSRDSGRGDSVSD-NGSEAVRSGVA------------VPTSPKGRLL 100

  Fly   123 PHRRWKNSRRSRTINRGRGLPKKGGGGGKGVWGLPGSEALAEVYE----DENDPNYDSECNDRNV 183
                   .||||: .:|||||||||.|||||||.||     :||:    |..|||||.:  ..|.
  Rat   101 -------DRRSRS-GKGRGLPKKGGAGGKGVWGTPG-----QVYDVEEVDVKDPNYDDD--QENC 150

  Fly   184 ELREVITEITREEFFKLAEPIVLEYYEHGDPHEVALSFDEILQAPMREHVTSILVEIAMDHKDSQ 248
            ....|:..:....|.|...||:.||:||||.:|||....::....|:..|..:.|.:|::.|.|.
  Rat   151 VYETVVLPLDETAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASH 215

  Fly   249 REMTSVLISDLYGRVITGKDIEKGFNMLLANLPDLVLDTPEAPIMLGNFMARAVAD--------- 304
            |||||.|:|||.|.|::..|:||.|:.||.:||:|.||||.||.::|.|:||||.|
  Rat   216 REMTSKLLSDLCGTVMSTNDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYID 280

  Fly   305 ------DCIPPKFVAKSGEELRHLGLGEHAEQALRRADSLI-YKHVWAHLDNVWGMGGPLRPVKT 362
                  ||:                   .|..||.:|..|: ........|:|||.||..:||..
  Rat   281 SYKGTVDCV-------------------QARAALDKATVLLSMSKGGKRKDSVWGSGGGQQPVNH 326

  Fly   363 ITMQMELLLKEYLSSRDVAEAQRCLRALEVPHYHHELVYEAIVMTLESLSQTTEEAMCELLKQLD 427
            :..::::||||||.|.|::||:.||:.|||||:|||||||||||.|||..::..:.|.:|||.|.
  Rat   327 LVKEIDMLLKEYLLSGDMSEAEHCLKELEVPHFHHELVYEAIVMVLESTGESAFKMMLDLLKSLW 391

  Fly   428 LTCLVLPAGMEQGFLRAFDDMADIVLDVPLAYIILDRFVERCNRAGFLTDKIINNVPSRGRKRFV 492
            .:..:....|::|:.|.::::.||.||||.:|.:|:||||.|.:||.::.::.:..|||||||||
  Rat   392 KSSTITIDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFV 456

  Fly   493 SEGDGGHVKPTTF 505
            ||||||.:||.::
  Rat   457 SEGDGGRLKPESY 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdcd4	NP_001096977.1	MA3	197..308	CDD:214714	54/125 (43%)
		MA3	363..476	CDD:280933	54/112 (48%)
Pdcd4	NP_071601.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	58..128		18/72 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	58..64		0/5 (0%)
		Phosphodegron. /evidence=ECO:0000250	70..76		4/5 (80%)
		MA3	164..275	CDD:214714	44/114 (39%)
		MA3	327..440	CDD:214714	50/113 (44%)
		Nuclear localization signal. /evidence=ECO:0000255	448..454		2/5 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352877
Domainoid	1	1.000	114	1.000	Domainoid score	I5958
eggNOG	1	0.900	-	-		E1_KOG0403
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7879
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2465
OMA	1	1.010	-	-		QHG58981
OrthoDB	1	1.010	-	-		D412881at33208
OrthoFinder	1	1.000	-	-		FOG0003154
OrthoInspector	1	1.000	-	-		oto97527
orthoMCL	1	0.900	-	-		OOG6_103300
Panther	1	1.100	-	-	O	PTHR12626
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2118
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770