DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdcd4 and pdcd4

DIOPT Version :9

Sequence 1:	NP_001096977.1	Gene:	Pdcd4 / 32337	FlyBaseID:	FBgn0030520	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_012821786.2	Gene:	pdcd4 / 407925	XenbaseID:	XB-GENE-959687	Length:	484	Species:	Xenopus tropicalis

Alignment Length:	559	Identity:	199/559 - (35%)
Similarity:	288/559 - (51%)	Gaps:	129/559 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVESNNKRATNGGRHFTPPSD------------SDSKESSVERELNEEIEAVELNGSGGGGHSN 53
            ||:|:              |||            |||:.|..|:...||               |
Frog     1 MEIET--------------PSDINANVANVANVESDSELSGAEQIKYEE---------------N 36

  Fly    54 GHVKKLMAVEDGRIKRKAKRLIQRQNSGSGGSANQTNGNGAAGAGGAHGASVMPLGINRIMPSPG 118
            |:|.: .::.:.|:..||||.:::.:|...|..:..:.||.:..|      |:|       .||.
Frog    37 GNVAE-SSLTEARLHAKAKRRLRKNSSRDSGRGDSVSDNGESARG------VLP-------TSPK 87

  Fly   119 GYVVPHRRWKNSRRSRTINRGRGLPKKGGGGGKGVWGLPGSEALAEVYEDE----NDPNYDSE-- 177
            ..::       .|:||| .:|||||||||.|||||||.||     ::|::|    .|||||.:
Frog    88 AKLM-------DRKSRT-GKGRGLPKKGGAGGKGVWGTPG-----QIYDEEVVDIKDPNYDEDQK 139

  Fly   178 -------------CND-RNVELREVITEIT-----REEFFKLAEPIVLEYYEHGDPHEVALSFDE 223
                         |.. :..:....:.|.|     .:.|.|...|||.||:||||.:|||.....
Frog   140 AEFLLRPWQPRACCGSIKGSDQESCVYETTVLPLDEKSFEKSVTPIVQEYFEHGDANEVAEMLKG 204

  Fly   224 ILQAPMREHVTSILVEIAMDHKDSQREMTSVLISDLYGRVITGKDIEKGFNMLLANLPDLVLDTP 288
            :....|:..:..:.|.:|::.|.|.|||||.|:|.|.|.:::.:|:|:.|:.||..:|:||||||
Frog   205 LNLGEMKCGLPVLAVSLALEGKASHREMTSKLLSHLCGTLLSTEDVERSFDKLLQEMPELVLDTP 269

  Fly   289 EAPIMLGNFMARAVAD---------------DCIPPKFVAKSGEELRHLGLGEHAEQALRRADSL 338
            :||.::|.|:||||.|               ||:                   ||..||.||..|
Frog   270 QAPQLVGQFIARAVGDEILSATYLDGYRGTVDCV-------------------HARAALDRAAVL 315

  Fly   339 --IYKHVWAHLDNVWGMGGPLRPVKTITMQMELLLKEYLSSRDVAEAQRCLRALEVPHYHHELVY 401
              |.|.....:|:|||.||...||..:..:::|||||::.|.||.||:|||:.|||||:||||||
Frog   316 LRITKGGRRRIDSVWGTGGGQLPVNKLVKEIDLLLKEFVLSGDVVEAERCLQELEVPHFHHELVY 380

  Fly   402 EAIVMTLESLSQTTEEAMCELLKQLDLTCLVLPAGMEQGFLRAFDDMADIVLDVPLAYIILDRFV 466
            ||::|.||:....|.:.|..||:.|..:..:....|::|:.|.:.::.||.||||.||.:|:|||
Frog   381 EAVLMVLEANGNNTYKMMLSLLEALLKSGAITLDQMKRGYDRIYQEIPDINLDVPKAYSVLERFV 445

  Fly   467 ERCNRAGFLTDKIINNVPSRGRKRFVSEGDGGHVKPTTF 505
            |.|.:||.::.:|.:..|.|||||||||||||.:|..::
Frog   446 EDCFKAGIISKQIRDLCPCRGRKRFVSEGDGGRLKSESY 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdcd4	NP_001096977.1	MA3	197..308	CDD:214714	51/125 (41%)
Pdcd4	NP_001096977.1	MA3	363..476	CDD:280933	53/112 (47%)
pdcd4	XP_012821786.2	MA3	178..289	CDD:214714	49/110 (45%)
pdcd4	XP_012821786.2	MA3	342..455	CDD:214714	53/112 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6283
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7879
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2474
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412881at33208
OrthoFinder	1	1.000	-	-		FOG0003154
OrthoInspector	1	1.000	-	-		otm48791
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5734
SonicParanoid	1	1.000	-	-		X2118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090