DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdcd4 and PDCD4

DIOPT Version :9

Sequence 1:	NP_001096977.1	Gene:	Pdcd4 / 32337	FlyBaseID:	FBgn0030520	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_055271.2	Gene:	PDCD4 / 27250	HGNCID:	8763	Length:	469	Species:	Homo sapiens

Alignment Length:	530	Identity:	198/530 - (37%)
Similarity:	291/530 - (54%)	Gaps:	86/530 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVESNNKRATNGGRHFTPPSDSDSKESSV-----ERELNEEIEAVELNGSGGGGHSNGHVKKLM 60
            |:||  |::..|     ..|:|.|:...|:     |....|||:. |:||:.....|
Human     1 MDVE--NEQILN-----VNPADPDNLSDSLFSGDEENAGTEEIKN-EINGNWISASS-------- 49

  Fly    61 AVEDGRIKRKAKRLIQRQNSGSGGSANQTNGNGAAGAGGAHGASVMPLGINRIMPSPGGYVVPHR 125
             :.:.||..||||.:::.:|...|..:..:.:         |:..:..|:. :..||.|.::
Human    50 -INEARINAKAKRRLRKNSSRDSGRGDSVSDS---------GSDALRSGLT-VPTSPKGRLL--- 100

  Fly   126 RWKNSRRSRTINRGRGLPKKGGGGGKGVWGLPGSEALAEVYE----DENDPNYDSECNDRNVELR 186
                .||||: .:|||||||||.|||||||.||     :||:    |..|||||.:  ..|....
Human   101 ----DRRSRS-GKGRGLPKKGGAGGKGVWGTPG-----QVYDVEEVDVKDPNYDDD--QENCVYE 153

  Fly   187 EVITEITREEFFKLAEPIVLEYYEHGDPHEVALSFDEILQAPMREHVTSILVEIAMDHKDSQREM 251
            .|:..:....|.|...||:.||:||||.:|||....::....|:..|..:.|.:|::.|.|.|||
Human   154 TVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREM 218

  Fly   252 TSVLISDLYGRVITGKDIEKGFNMLLANLPDLVLDTPEAPIMLGNFMARAVAD------------ 304
            ||.|:|||.|.|::..|:||.|:.||.:||:|.||||.||.::|.|:||||.|
Human   219 TSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYK 283

  Fly   305 ---DCIPPKFVAKSGEELRHLGLGEHAEQALRRADSLI-YKHVWAHLDNVWGMGGPLRPVKTITM 365
               ||:                   .|..||.:|..|: ........|:|||.||..:.|..:..
Human   284 GTVDCV-------------------QARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVK 329

  Fly   366 QMELLLKEYLSSRDVAEAQRCLRALEVPHYHHELVYEAIVMTLESLSQTTEEAMCELLKQLDLTC 430
            ::::||||||.|.|::||:.||:.|||||:|||||||||:|.|||..::|.:.:.:|||.|..:.
Human   330 EIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSS 394

  Fly   431 LVLPAGMEQGFLRAFDDMADIVLDVPLAYIILDRFVERCNRAGFLTDKIINNVPSRGRKRFVSEG 495
            .:....|::|:.|.::::.||.||||.:|.:|:||||.|.:||.::.::.:..||||||||||||
Human   395 TITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEG 459

  Fly   496 DGGHVKPTTF 505
            |||.:||.::
Human   460 DGGRLKPESY 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdcd4	NP_001096977.1	MA3	197..308	CDD:214714	54/125 (43%)
Pdcd4	NP_001096977.1	MA3	363..476	CDD:280933	53/112 (47%)
PDCD4	NP_055271.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		13/43 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..128		31/87 (36%)
		Nuclear localization signal. /evidence=ECO:0000255	58..64		4/5 (80%)
		Phosphodegron	70..76		1/5 (20%)
		MA3	164..275	CDD:214714	52/110 (47%)
		Nuclear localization signal. /evidence=ECO:0000255	241..250		4/8 (50%)
		MA3	327..440	CDD:214714	53/112 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158879
Domainoid	1	1.000	115	1.000	Domainoid score	I6052
eggNOG	1	0.900	-	-		E1_KOG0403
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7879
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2572
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58981
OrthoDB	1	1.010	-	-		D412881at33208
OrthoFinder	1	1.000	-	-		FOG0003154
OrthoInspector	1	1.000	-	-		oto90413
orthoMCL	1	0.900	-	-		OOG6_103300
Panther	1	1.100	-	-	O	PTHR12626
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5734
SonicParanoid	1	1.000	-	-		X2118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800