DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdcd4 and Pdcd4

DIOPT Version :9

Sequence 1:	NP_001096977.1	Gene:	Pdcd4 / 32337	FlyBaseID:	FBgn0030520	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001161963.1	Gene:	Pdcd4 / 18569	MGIID:	107490	Length:	469	Species:	Mus musculus

Alignment Length:	533	Identity:	200/533 - (37%)
Similarity:	289/533 - (54%)	Gaps:	92/533 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVESNNKRATNGGRHFTPPSDSDSKESSV-----ERELNEEIEAVELNGSGGGGHSNGHVKKLM 60
            |::|:......|       |:|.|:...|:     |....|||:          ...||:.....
Mouse     1 MDIENEQTLNVN-------PTDPDNLSDSLFSGDEENAGTEEIK----------NEINGNWISAS 48

  Fly    61 AVEDGRIKRKAKRLIQR---QNSGSGGSANQTNGNGAAGAGGAHGASVMPLGINRIMPSPGGYVV 122
            .:.:.||..||||.:::   ::||.|.|.:. ||:.|..:|.|            :..||.|.::
Mouse    49 TINEARINAKAKRRLRKNSSRDSGRGDSVSD-NGSEAVRSGVA------------VPTSPKGRLL 100

  Fly   123 PHRRWKNSRRSRTINRGRGLPKKGGGGGKGVWGLPGSEALAEVYE----DENDPNYDSECNDRNV 183
                   .||||: .:|||||||||.|||||||.||     :||:    |..|||||.:  ..|.
Mouse   101 -------DRRSRS-GKGRGLPKKGGAGGKGVWGTPG-----QVYDVEEVDVKDPNYDDD--QENC 150

  Fly   184 ELREVITEITREEFFKLAEPIVLEYYEHGDPHEVALSFDEILQAPMREHVTSILVEIAMDHKDSQ 248
            ....|:..:....|.|...||:.||:||||.:|||....::....|:..|..:.|.:|::.|.|.
Mouse   151 VYETVVLPLDETAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASH 215

  Fly   249 REMTSVLISDLYGRVITGKDIEKGFNMLLANLPDLVLDTPEAPIMLGNFMARAVAD--------- 304
            |||||.|:|||.|.|::..|:||.|:.||.:||:|.||||.||.::|.|:||||.|
Mouse   216 REMTSKLLSDLCGTVMSTNDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYID 280

  Fly   305 ------DCIPPKFVAKSGEELRHLGLGEHAEQALRRADSLI-YKHVWAHLDNVWGMGGPLRPVKT 362
                  ||:                   .|..||.:|..|: ........|:|||.||..:||..
Mouse   281 SYKGTVDCV-------------------QARAALDKATVLLSMSKGGKRKDSVWGSGGGQQPVNH 326

  Fly   363 ITMQMELLLKEYLSSRDVAEAQRCLRALEVPHYHHELVYEAIVMTLESLSQTTEEAMCELLKQLD 427
            :..::::||||||.|.|::||:.||:.|||||:|||||||||||.|||..::..:.:.:|||.|.
Mouse   327 LVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIVMVLESTGESAFKMILDLLKSLW 391

  Fly   428 LTCLVLPAGMEQGFLRAFDDMADIVLDVPLAYIILDRFVERCNRAGFLTDKIINNVPSRGRKRFV 492
            .:..:....|::|:.|.::::.||.||||.:|.:|:||||.|.:||.::.::.:..|||||||||
Mouse   392 KSSTITIDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFV 456

  Fly   493 SEGDGGHVKPTTF 505
            ||||||.:||.::
Mouse   457 SEGDGGRLKPESY 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdcd4	NP_001096977.1	MA3	197..308	CDD:214714	54/125 (43%)
Pdcd4	NP_001096977.1	MA3	363..476	CDD:280933	53/112 (47%)
Pdcd4	NP_001161963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		8/40 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..128		18/72 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	58..64		0/5 (0%)
		Phosphodegron. /evidence=ECO:0000250	70..76		4/5 (80%)
		MA3	164..275	CDD:214714	44/114 (39%)
		MA3	327..440	CDD:214714	49/113 (43%)
		Nuclear localization signal. /evidence=ECO:0000255	448..454		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849256
Domainoid	1	1.000	113	1.000	Domainoid score	I6171
eggNOG	1	0.900	-	-		E1_KOG0403
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7879
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2530
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58981
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003154
OrthoInspector	1	1.000	-	-		oto93998
orthoMCL	1	0.900	-	-		OOG6_103300
Panther	1	1.100	-	-	O	PTHR12626
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5734
SonicParanoid	1	1.000	-	-		X2118
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790