Protein Alignment Mrgn1 and Mgrn1

DIOPT Version :10

• Sequence 1: NP_572915.1
• Gene: Mrgn1 / 32330
• FlyBaseID: FBgn0030514
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_001365941.1
• Gene: Mgrn1 / 17237
• MGIID: 2447670
• Length: 578
• Species: Mus musculus
• Alignment Length: 692
• Identity: 250/692 - (36%)
• Similarity: 338/692 - (48%)
• Gaps: 178/692 - (25%)

  Fly     1 MGNFVSRQNAAVEEADPSTNNAYKYPPRMGNFFGTHFIMGGERFDTPQPESYLFGENADLNFLGN 65
            ||:.:||:.|.||:.|...|:||:|||:.||:|.:||.||||:||||.||.||||||.||||||:
Mouse     1 MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGS 65

  Fly    66 RPTAFPYPPPQANEPTKTLKSLVNIRKESVRFVKTMNDKKLGGVLEKPKMKEIDRDLDLDKEKSN 130
            ||..|||..|..:||.|||:|||||||:|:|.|:.                         ||.::
Mouse    66 RPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRY-------------------------KEDAD 105

  Fly   131 VTIEDVDGNVLCSMGLGGGDADMTPPPPPCSYNIEFTFDSDAKCAITIYYFCSED-VSPSGVTLV 194
            ...||.:                   .|...|::|||||:||:.|||||....|: |:...|...
Mouse   106 SPTEDGE-------------------KPRVLYSLEFTFDADARVAITIYCQAVEELVNGVAVYSC 151

  Fly   195 PREGLTSETYHYEKGINQCFSQPSHVFNPQQMPEDELGYSPGREQYPVAIHCVVEEGS--DECRQ 257
            ....|.|||.||::|::|.||.||...:..:..:|||.:...|..:||.|..||:||.  :....
Mouse   152 KNPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGH 216

  Fly   258 SHTTICVIDHHPENGSYVLRALKQKIFVDGLCYLLQEIYGIENKAVNKTS-LDEEIDDHGSECVI 321
            :|..:...:.|.: ||:.::.||||..||.:.||||||||||||...:|. .|:|..|:.||||:
Mouse   217 AHVLLAAFEKHVD-GSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSSECVV 280

  Fly   322 CMSETRDTLILPCRHLCLCNSCADSLRYQANNCPICRAPFRALLQIRAVQK------GIS-THVL 379
            |:|:.||||||||||||||.||||:||||||||||||.|||||||||||:|      .|| :.||
Mouse   281 CLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPISFSPVL 345

  Fly   380 HQNT---------------PTSAAG-----EPAPVDVPPGYIPVSLIEALNGPPQYVARARNSEH 424
            .|:.               |.|.|.     |.:...:||||.|:||:|||||
Mouse   346 AQSVDHDEHSCPFKKSKSHPASLASKKPKRETSSDSIPPGYEPISLLEALNG------------- 397

  Fly   425 DVTDSAATVAASTMTSADIKATSPIKSSSQRRPKIKKNASTCTSTSEVGTITNQSGGGNGSSTHS 489
                              ::|.||...|:....:|                 ..||..:|.|..|
Mouse   398 ------------------LRAVSPAIPSAPLYEEI-----------------TYSGISDGLSQAS 427

  Fly   490 VEI-------ESDPKKSSTATCTSP--TLGASTSPEPKQDKLQIVNERKYPRSTAG-------SG 538
            ..:       ||..:|..|.: .||  ||.:.:.|..::|:.::..:...|...:|       |.
Mouse   428 CPLAGLDRIMESGLQKGKTQS-KSPDSTLRSPSFPIHEEDEEKLSEDSDAPLPPSGVELVLRESS 491

  Fly   539 GDGSAGTDDDVDSENEKLSPLLSPGSKSKNVSSKSLKQVVACLEADDDVDNKSSTGDG------- 596
            ...|.||::..:       |.|..||:..::              ||.:.:.|....|
Mouse   492 SPESFGTEEGDE-------PSLKQGSRVPSI--------------DDVLQDGSPQHHGCSQPVPP 535

  Fly   597 -----PTEESSLKKGSSIKRT-KPRPELSGSGAPSP--AEAT 630
                 |...:|::...|:..| .|.|.|||| :|.|  ||.|
Mouse   536 ADIYLPGWSTSMETPHSLGTTSSPWPLLSGS-SPEPGVAELT 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrgn1	NP_572915.1	PEX10	<255..359	CDD:227861	61/104 (59%)
		RING_Ubox	314..372	CDD:473075	48/57 (84%)
Mgrn1	NP_001365941.1	mRING-HC-C3HC5_MGRN1	268..325	CDD:438465	44/56 (79%)