Protein Alignment Mrgn1 and RNF157

DIOPT Version :10

• Sequence 1: NP_572915.1
• Gene: Mrgn1 / 32330
• FlyBaseID: FBgn0030514
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_001425650.1
• Gene: RNF157 / 114804
• HGNCID: 29402
• Length: 680
• Species: Homo sapiens
• Alignment Length: 811
• Identity: 274/811 - (33%)
• Similarity: 382/811 - (47%)
• Gaps: 193/811 - (23%)

  Fly     1 MGNFVSRQNAAVEEADPSTNNAYKYPPRMGNFFGTHFIMGGERFDTPQPESYLFGENADLNFLGN 65
            ||...|||:|.|||.|..:|:.|:|||:.|::|.:|||||||:||:..||.||||||:|||||||
Human     1 MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDLNFLGN 65

  Fly    66 RPTAFPY--PPPQANEPTKTLKSLVNIRKESVRFVKTMNDKKLGGVLEKPKMKEIDRDLDLDKEK 128
            ||..|||  ||||  ||.|||:|||||||:::|.||...:.|..|                 :|.
Human    66 RPVVFPYAAPPPQ--EPVKTLRSLVNIRKDTLRLVKCAEEVKSPG-----------------EEA 111

  Fly   129 SNVTIEDVDGNVLCSMGLGGGDADMTPPPPPCSYNIEFTFDSDAKCAITIYYFCSEDVSPSGVTL 193
            |...:.                           ||:|||||:||:.||||||..:|:......:.
Human   112 SKAKVH---------------------------YNVEFTFDTDARVAITIYYQATEEFQNGIASY 149

  Fly   194 VPRE-GLTSETYHYEKGINQCFSQPSHVFNPQQMPEDELGYSPGREQYPVAIHCVVEEGSDECRQ 257
            :|:: .|.|||..|::|:.|.|..|||..:|.:..|:|||:...||.||:.:|.||:||.:....
Human   150 IPKDNSLQSETVQYKRGVCQQFCLPSHTVDPSEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGH 214

  Fly   258 SHTTICVIDHHPENGSYVLRALKQKIFVDGLCYLLQEIYGIENKAVNKTS--LDEEIDDHGSECV 320
            .|..:...:.|.: |::.::.||||..|||:.||||||||||||...:.|  .::|:.|:.:|||
Human   215 CHVLLGTFEKHTD-GTFCVKPLKQKQVVDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECV 278

  Fly   321 ICMSETRDTLILPCRHLCLCNSCADSLRYQANNCPICRAPFRALLQIRAVQKGI------STHVL 379
            :|:|:.|||||||||||||||:|||:||||||||||||.||||||||||::|.:      |.:.:
Human   279 VCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPI 343

  Fly   380 HQNTPTSAAGEPAPVDVPPGYIPVSLIEALNGPPQYVARARNSEHDVTDSAATVAASTMTSADIK 444
            ..:..:.:...|:..::||||..|||:||||||             :|.|.|......:....:.
Human   344 ISSQTSDSEEHPSSENIPPGYEVVSLLEALNGP-------------LTPSPAVPPLHVLGDGHLS 395

  Fly   445 ATSP-------------------IKSSSQRRPKIKKNASTCTSTSEVGTITNQSGGGNGSSTHSV 490
            ...|                   :..||.:..|:||:.|..||.             |.|..|..
Human   396 GMLPSYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQ-------------NSSVLHEE 447

  Fly   491 EIESDPKKSSTATCTSPT---LGASTSPEPKQDKLQIVNERKYPRSTAGSGGDGSAGTDDDVDSE 552
            |.|....:|.|.....|:   ||......|:.:.|.:        |::|:           :|..
Human   448 EDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTL--------SSSGA-----------IDQS 493

  Fly   553 NEKLSPLLSPGSKSKNVSSKSLKQVVACLEAD----DDVDNKSSTGDGP-TEESSLKKGSSIKRT 612
            :...:||.|..|..:..:|.||.|.|..:.:.    |.|.:.|.:...| |||    :|.::...
Human   494 SCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEE----EGEALSSP 554

  Fly   613 KP---RPELSGSGAPS----------PA-EATAEDSDYYTPEDTQNSILSPLCPTERAKSGDPLG 663
            :|   .|...|.|.|:          || |..||.:|....||                 |.|..
Human   555 QPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEED-----------------GSPTQ 602

  Fly   664 AGSLGNGGLSVGRSAGSVGGQAGVGPVVVGFSSAVKKNLHKKSTSVGNMVGSGSVTTVVDLKSNN 728
            .|.        .|:...:|.:.....   .|..|..|.|..|..|...:.|:....
Human   603 EGG--------QRTCAFLGMECDNNN---DFDIASVKALDNKLCSEVCLPGAWQAD--------- 647

  Fly   729 VSSLPDMLDSPISGNSASTRSSSDSYSSSSS 759
                    |:.:|.|:...|.||.|...|.:
Human   648 --------DNAVSRNAQRRRLSSSSLEDSET 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrgn1	NP_572915.1	PEX10	<255..359	CDD:227861	59/105 (56%)
		RING_Ubox	314..372	CDD:473075	46/57 (81%)
RNF157	NP_001425650.1	D-box 1. /evidence=ECO:0000303|PubMed:28655764	329..332		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	339..362		2/22 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	651..680		7/20 (35%)
		D-box 2. /evidence=ECO:0000303|PubMed:28655764	657..660		0/2 (0%)