Protein Alignment HOXD4 and cad

DIOPT Version :10

• Sequence 1: NP_055436.2
• Gene: HOXD4 / 3233
• HGNCID: 5138
• Length: 255
• Species: Homo sapiens
• Sequence 2: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Alignment Length: 287
• Identity: 82/287 - (28%)
• Similarity: 112/287 - (39%)
• Gaps: 99/287 - (34%)

Human    39 GGAQGADFQPPGLYPRPDFGEQ----PFGGSGPGPGSALPARGHGQEPGGPG----GHYAAPGEP 95
            |||.||          |...|.    ..||:|.|.|..      |...||||    .|.....|.
  Fly   129 GGAPGA----------PQLNETNSSIGVGGAGGGGGVG------GATDGGPGSAPPNHQQHIAEG 177

Human    96 CPAPP--------APPPAPLPGARAY--------------------------------------- 113
            .|:||        :.|.||...:..:
  Fly   178 LPSPPITVSGSEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNN 242

Human   114 SQSDPKQPPSGTALKQPAVVYPWMKKVHVNSVNPNY--------TGGEPK---RSRTAYTRQQVL 167
            :::.|.:||....:|:||  ||...:..::| :||.        ..|:.:   :.|..||..|.|
  Fly   243 NRTSPSKPPYFDWMKKPA--YPAQPQPDLSS-SPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRL 304

Human   168 ELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKL---PNTKG---RSSSSS 226
            |||||:..:||:|.||:.|:|.||.|||||:||||||||.|.:|.:|.   ||..|   :.:..|
  Fly   305 ELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNKKGSDPNVMGVGVQHADYS 369

Human   227 SSSSCSSSVAPSQHL--------QPMA 245
            ......:.:.|..||        .|||
  Fly   370 QLLDAKAKLEPGLHLSHSLAHSMNPMA 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXD4	NP_055436.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..127		28/142 (20%)
		Antp-type hexapeptide	133..138		2/4 (50%)
		Homeodomain	155..211	CDD:459649	33/58 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..255		11/48 (23%)
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	33/54 (61%)