Protein Alignment HOXD4 and H2.0

DIOPT Version :10

• Sequence 1: NP_055436.2
• Gene: HOXD4 / 3233
• HGNCID: 5138
• Length: 255
• Species: Homo sapiens
• Sequence 2: NP_523488.2
• Gene: H2.0 / 33841
• FlyBaseID: FBgn0001170
• Length: 418
• Species: Drosophila melanogaster
• Alignment Length: 279
• Identity: 67/279 - (24%)
• Similarity: 95/279 - (34%)
• Gaps: 103/279 - (36%)

Human    48 PPGLYPRPDFGEQPFGGSG---PGP----GSAL---PARGHGQEPGGPGGHYAAPGEPCPAPPA- 101
            ||...|.... ..||.|..   |||    .|.|   |.|         ...:|||..|..|..|
  Fly   131 PPTFTPTSSH-TYPFVGLDKLFPGPYMDYKSVLRPTPIR---------AAEHAAPTYPTLATNAL 185

Human   102 -----------------------------PPP----------APLPGARAYSQSDPKQPPSGTAL 127
                                         |||          |||....:...:..:|...|...
  Fly   186 LRFHQHQKQQHQQHHHHQHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLTQQQQRFLGKTP 250

Human   128 KQPAVVYPWMKKVHVNSVNPN----------------YTGGEPKR--SRTAYTRQQVLELEKEFH 174
            :|...:.|........:.:.|                .:.|:.||  ||..::..|...||.:|.
  Fly   251 QQLLDIAPTSPAAAAAATSQNGAHGHGGGNGQGNASAGSNGKRKRSWSRAVFSNLQRKGLEIQFQ 315

Human   175 FNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKW------------KKDHKLPNTKG--RSSSS 225
            ..:|:|:..|.::|..|.|::.|:|:|||||||||            |:...:|.:.|  ::|:.
  Fly   316 QQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKWRHTRENLKSGQEKQPSAVPESGGVFKTSTP 380

Human   226 S-----------SSSSCSS 233
            |           ||.||||
  Fly   381 SGDGTPQEALDYSSDSCSS 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXD4	NP_055436.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..127		27/128 (21%)
		Antp-type hexapeptide	133..138		1/4 (25%)
		Homeodomain	155..211	CDD:459649	25/69 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..255		10/35 (29%)
H2.0	NP_523488.2	Homeodomain	292..352	CDD:459649	25/59 (42%)