Protein Alignment Nna1 and AGBL5

DIOPT Version :10

• Sequence 1: NP_001285225.1
• Gene: Nna1 / 32329
• FlyBaseID: FBgn0265726
• Length: 1890
• Species: Drosophila melanogaster
• Sequence 2: NP_068603.4
• Gene: AGBL5 / 60509
• HGNCID: 26147
• Length: 886
• Species: Homo sapiens
• Alignment Length: 937
• Identity: 216/937 - (23%)
• Similarity: 340/937 - (36%)
• Gaps: 321/937 - (34%)

  Fly   620 GLEFESRFESGNLAKAVQI-----------------------TPTY-YELYLRPDL----YTSRS 656
            ||.|.|||:|||||...::                       :|.| :.::.|||.    :.:.:
Human     7 GLLFSSRFDSGNLAHVEKVESLSSDGEGVGGGASALTSGIASSPDYEFNVWTRPDCAETEFENGN 71

  Fly   657 KQWFYFRVRRTRRKMLYRFSIVNLVKSDSLYNDGMQPVMYSTLGAKEKSEGWRRCGDNICYYRND 721
            :.||||.||......|.:.:|:|:.|...||:.||.|.: .||..:.:   |.|..|...:...:
Human    72 RSWFYFSVRGGMPGKLIKINIMNMNKQSKLYSQGMAPFV-RTLPTRPR---WERIRDRPTFEMTE 132

  Fly   722 DESASSSANEDDEDNSTYTLTFTIEF-EHDDDTVFFAHSYPYTYSDLQDYLMEI-----QRHPVK 780
            .:               :.|:|...| |....|.|||..||::|||.|:.|.::     :.||..
Human   133 TQ---------------FVLSFVHRFVEGRGATTFFAFCYPFSYSDCQELLNQLDQRFPENHPTH 182

  Fly   781 SK-----FCKLRLLCRTLAGNNVYYLTVTA----------------PSSNEENMRR---KKSIVV 821
            |.     :....|||.:|.|..|..||:|:                |.::.....|   |:...:
Human   183 SSPLDTIYYHRELLCYSLDGLRVDLLTITSCHGLREDREPRLEQLFPDTSTPRPFRFAGKRIFFL 247

  Fly   822 SARVHPSETPASWMMKGLMDFI-TGDTTVAKRLRHKFIFKLVPMLNPDGVIVGNTRNSLTGKDLN 885
            |:||||.|||:|::..|.:||| ..|...|:.||..|:|||:||||||||:.|:.|....|.:||
Human   248 SSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLN 312

  Fly   886 RQYRTVIRETYPSIWYTKAMI------RRL----------------------------------- 909
            |||.......:|:|:..||::      .||
Human   313 RQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNSQSSSEHQPSSCLPPDAPVSDLEKANNLQNEAQC 377

  Fly   910 --------------------------------------------IEECGVAMYCDMHAHSRKHNI 930
                                                        .:|.|||.|.|:|.|:.|...
Human   378 GHSADRHNAEAWKQTEPAEQKLNSVWIMPQQSAGLEESAPDTIPPKESGVAYYVDLHGHASKRGC 442

  Fly   931 FIYGCENKRNPEKKLTE-QVFPLMLHKNSADRFSFESCKFKIQ----------RSKEGTGRIVVW 984
            |:||  |..:.|....| .::|.::..||| .|.|:.|.|..:          :||||:||:.::
Human   443 FMYG--NSFSDESTQVENMLYPKLISLNSA-HFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIY 504

  Fly   985 ML-GITNSYTIEASFG-GSSLGSRKG-----------------THFNTQDYEHMGRAFCETLLDY 1030
            .. ||.:|||:|.::. |.|:.|...                 :.:..:.:|.:|||.....||.
Human   505 KASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPAFPSRYTVELFEQVGRAMAIAALDM 569

  Fly  1031 --CDENPNKILNLLKQQDRLRSKIIERLMREGSSADEPLNI----------PLSDYSSDEGNCSS 1083
              |:..|..:|:.......||:.:::. :|........||:          |...::....:||.
Human   570 AECNPWPRIVLSEHSSLTNLRAWMLKH-VRNSRGLSSTLNVGVNKKRGLRTPPKSHNGLPVSCSE 633

  Fly  1084 SSDNEGKHSITTSDLEGPCCAPTRAP-----PSSPEVIHEIRKFRMRRM----RKVMHELDRIYF 1139
            ::.:..:...|.:...|...:...:|     ||.|  .|..|...:..:    :||.|.:    .
Human   634 NTLSRARSFSTGTSAGGSSSSQQNSPQMKNSPSFP--FHGSRPAGLPGLGSSTQKVTHRV----L 692

  Fly  1140 TPLFQRKFKTLTTLKRRRQKMGVKAAPSGKRLRGGGGPAVSAATPTPAPAVQAAAPVVETNDVQK 1204
            .|:.:.:     :..||||:..:...|:|            :..|:|||.
Human   693 GPVREPR-----SQDRRRQQQPLNHRPAG------------SLAPSPAPT--------------- 725

  Fly  1205 LHTPRQLARSLPSNSDQPTGGQSSDSSESMDSSQSESLLEPD-----GSSGSTAASKEVTKKVKT 1264
                                     ||....|.:..|.|.||     |||.|..:|.:..:.|..
Human   726 -------------------------SSGPASSHKLGSCLLPDSFNIPGSSCSLLSSGDKPEAVMV 765

  Fly  1265 SGAGTKKTAKKKKFMPTEKKKPVVNQKLHVDRNFRLWLANRRIYIYRRKKSTQARRTKVRNKPSK 1329
            .|.|         .:.|..:.|.:..:|                        |||....|..|..
Human   766 IGKG---------LLGTGARMPCIKTRL------------------------QARPRLGRGSPPT 797

  Fly  1330 KRGEVVRT--TLDLPTTDPGSDLHFST 1354
            :||....:  |...|.|...|:|...:
Human   798 RRGMKGSSGPTSPTPRTRESSELELGS 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nna1	NP_001285225.1	Pepdidase_M14_N	623..758	CDD:407865	41/163 (25%)
		M14_AGBL2-3_like	780..1031	CDD:349478	100/392 (26%)
AGBL5	NP_068603.4	Pepdidase_M14_N	10..155	CDD:407865	41/163 (25%)
		M14_AGBL5_like	183..574	CDD:349455	101/393 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..364		0/19 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	605..734		30/191 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	784..848		13/65 (20%)