Protein Alignment Nna1 and agbl2

DIOPT Version :10

• Sequence 1: NP_001285225.1
• Gene: Nna1 / 32329
• FlyBaseID: FBgn0265726
• Length: 1890
• Species: Drosophila melanogaster
• Sequence 2: XP_073798308.1
• Gene: agbl2 / 568152
• ZFINID: ZDB-GENE-070719-6
• Length: 1035
• Species: Danio rerio
• Alignment Length: 1741
• Identity: 434/1741 - (24%)
• Similarity: 602/1741 - (34%)
• Gaps: 817/1741 - (46%)

  Fly     3 KGVKD---KENRNSAMGPEI----CEVQQHPSKQNDGFLGSFLSKGLKTNQLVVNTDEKTLRPVA 60
            :|::|   .:..||:...|.    .|.:|..||....|..  |:|.|:|.|||.:.|.:  ||:.
Zfish    38 EGIQDSTASDMINSSSPSESSDSNLEEEQEESKPCSNFFS--LNKALRTRQLVFDFDGE--RPIP 98

  Fly    61 RLKEPRDLFALPKDKDNDCSQQAPRWPVECQVIEERIIHIPYVPAVPEPLNAPTGNELKPRPVGE 125
            ||::|.|||.:|   ...|..|..|||:||.||.::|.||.:.|:.||....|||||..|.||||
Zfish    99 RLRDPLDLFTIP---STSCPFQGVRWPIECDVICDKIQHIEWDPSEPETFYQPTGNEQTPMPVGE 160

  Fly   126 ENGIVVFSYSPISAVNYEKPKAKKEDDESSDESDYSSDSRQDSTPPSRSTPMRLAGGGECAPGKL 190
            ..|
Zfish   161 VRG-------------------------------------------------------------- 163

  Fly   191 NSVSKMINNVDNRSTSASLDDNDDYYDDEYDTSGGYCGGSGEAKEKAIIKDLIEAKKKRYQEEAE 255
            |:|                                ||
Zfish   164 NTV--------------------------------YC---------------------------- 168

  Fly   256 VTPVGGGTARNSRAASRSEASKDASDIDDIWKNNTSEYKPASPRYVLSQFGKNVTKAVIDRIVDH 320
                                      ||           ||             |||
Zfish   169 --------------------------ID-----------PA-------------TKA-------- 175

  Fly   321 EDLVPPSGSQKVSNQFAVGPVKLPKTNIARLEVAFERSACQDRSKSRLKKKMSSSRRRRESTSDE 385
                                                                             
Zfish   176 ----------------------------------------------------------------- 175

  Fly   386 DSSSSSLGNEEDEEVDDSDSDAENTGSGIGLRRILGSYSARLAGGAEKCPCPGSGSVSDTETLVG 450
                                                ||.
Zfish   176 ------------------------------------SYF-------------------------- 178

  Fly   451 DESRSRLAGSNGLHQQDVVCSRNRQAQSRSPLRSVPHTHAATVAAAAAALARGRNRDKDGCLGGK 515
              :.||:.||.|                  |::|.
Zfish   179 --TYSRVGGSRG------------------PIKSA------------------------------ 193

  Fly   516 DEKNMGMGVGTTGTSSMGTRTSSPVRNNVFRLSKDQHILLNSMTSQETTGTLISSTSTNQTTTTT 580
                                                                 :|.:.||...|
Zfish   194 -----------------------------------------------------TSCANNQKEPT- 204

  Fly   581 NSSQSFLCSDLPQAQFSRSAVGGARFMTNCHPMNPEEYDGLEFESRFESGNLAKAVQITPTYYEL 645
                                                    |.||||||.|||.||||:....|||
Zfish   205 ----------------------------------------LAFESRFECGNLQKAVQVGQYDYEL 229

  Fly   646 YLRPDLYTSRSKQWFYFRVRRTRRKMLYRFSIVNLVKSDSLYNDGMQPVMYSTLGAKEKSEGWRR 710
            .||.||||::..||||||||..|..:.|||:|:||:||.|||..||.|::||...|..|.|||:|
Zfish   230 TLRTDLYTTKHTQWFYFRVRNMREGVTYRFTIINLMKSSSLYGAGMCPLLYSEKTAWLKGEGWKR 294

  Fly   711 CGDNICYYRNDDESASSSANEDDEDNSTYTLTFTIEFEHDDDTVFFAHSYPYTYSDLQDYLMEIQ 775
            .|.:|.||||         |.:.:..:.|:||:|:||.:|.||.:.||.||||||.||.||.|:.
Zfish   295 TGSSIRYYRN---------NIEQDGKALYSLTWTLEFPYDGDTCYLAHCYPYTYSKLQHYLREVI 350

  Fly   776 RHPVKSKFCKLRLLCRTLAGNNVYYLTVTAPSSNEENMRRKKSIVVSARVHPSETPASWMMKGLM 840
            ..||::.:||||:|||:||||.||.||:|||||:....:.|:::||:|||||.||..||||:|.:
Zfish   351 SDPVRAAYCKLRVLCRSLAGNAVYVLTITAPSSSLAERKAKRAVVVTARVHPGETNGSWMMQGFL 415

  Fly   841 DFITGDTTVAKRLRHKFIFKL---------VPMLNPDGVIVGNTRNSLTGKDLNRQYRTVIRETY 896
            :|:..|...|..||..|||||         :||||||||:|||.|.||.|:||||.||:::|:::
Zfish   416 EFLLSDLPDAHLLRETFIFKLDLQMFWPQVIPMLNPDGVVVGNYRCSLAGRDLNRNYRSMLRDSF 480

  Fly   897 PSIWYTKAMIRRLIEECGVAMYCDMHAHSRKHNIFIYGCENKRNPEKKLTEQVFPLMLHKNSADR 961
            |.||||:.|::||:.|..|.:|||.|.||||:|:|:|||..:::..:.|.|:|||||:.||:.|:
Zfish   481 PCIWYTRNMVKRLLAEREVVVYCDFHGHSRKNNVFMYGCNERKDASQCLQERVFPLMMSKNAKDK 545

  Fly   962 FSFESCKFKIQRSKEGTGRIVVWMLGITNSYTIEASFGGSSLGSRKGTHFNTQDYEHMGRAFCET 1026
            |||.|||||:.:|||||||||:|.|||.||||:|::||||:||.||||||:|.|.:.||..||:|
Zfish   546 FSFRSCKFKMHKSKEGTGRIVMWRLGIRNSYTMESTFGGSTLGDRKGTHFSTLDLKSMGYCFCDT 610

  Fly  1027 LLDYCDENPNKILNLLKQQD-RLRSKIIERLMREGSSADEPLNIPLSDYSSDEGNCSSSSDNEGK 1090
            |||:||.:|.|:...|::.. .|:.:|..:|.||..|.:...:|.:.  ||..|:.|:.||....
Zfish   611 LLDFCDPDPAKMTRCLEELGVLLKQEIRRKLGREVDSLENLSDIDIE--SSTSGSNSTESDGLPV 673

  Fly  1091 HSITTSDLEGPCCAPTRAPPSSPEVIHEIRKFRMRRMRKVMHELDRIYFTPLFQRKFKTLTTLKR 1155
            |.:..::                                              |.|.|.|.:.|.
Zfish   674 HLLNVTN----------------------------------------------QGKKKLLRSRKE 692

  Fly  1156 RRQKMGVKAAPSGKRLRGGGGPAVSAATPTPAPAVQAAAPVVETNDVQKLHTPRQLARSLPSNSD 1220
            |            .|||.|              .||:|.|.:...:::.|.       .:|||.|
Zfish   693 R------------NRLRQG--------------RVQSAGPKIFQRNIKHLD-------PVPSNED 724

  Fly  1221 QPTGGQSSDSSESMDSSQSESLLEPDGSSGSTAASKEVTKKVKTSGAGTKKTAKKKKFMPTEKKK 1285
                                                .|..:::.......|.|||:| :|.
Zfish   725 ------------------------------------AVKVRIQEKTTCYVKDAKKQK-VPC---- 748

  Fly  1286 PVVNQKLHVDRNFRLWLANRRIYIYRRKKSTQARRTKVRNKPSKKRGEVVRTTLDLPTTDPG--- 1347
                                                      |.:..:.||:.:..|||..|
Zfish   749 ------------------------------------------SGRANQTVRSWIPHPTTHIGVID 771

  Fly  1348 --SDLHFSTDDEEHSPTSGHNGYGAVPPLRHTLLQSDLQRRYIEEIGDTVVQKPKASHMPPELIV 1410
              .|:..:..|:....|:.|||:.|   .||::                     ...|
Zfish   772 NVPDIWENRLDKISPATNLHNGFSA---FRHSV---------------------SVDH------- 805

  Fly  1411 TTPSKSGTPGGGKKLDVYKLTPRTAPELDTGIGMMQRQAGGTGTSARRTYSWHNLDQQEIPNGNG 1475
                       |.|  .|:....:||:     |.:|||......|.:|..|        :|....
Zfish   806 -----------GHK--TYQNATSSAPQ-----GQLQRQTHLVAGSHKRCPS--------VPASQE 844

  Fly  1476 GGQGKANFYIGDTKPGIKTMAKPLPRRSVPSNFIPQ-----------RHGNVQTADDLQLKLSLK 1529
                             :|:..|:|  |...:|.|:           ...|:....  |.||..:
Zfish   845 -----------------RTLTMPVP--SYTMSFYPEFRPQPELKGRPHISNIMARS--QQKLRQE 888

  Fly  1530 KKVWTGANGDADGRPLAWYKGHSITASQMANTTTTIRSAGGGAAGGGGAGAGAGAGGGGGGQNRN 1594
            :::...........||     |::...::::.|            .|.||||||
Zfish   889 RQMQVNHIPVKHLMPL-----HNMGTLRISHKT------------DGQAGAGAG----------- 925

  Fly  1595 MFPSNGREQT----------------------------AASGGIAMGVPPAFVGAPRRVRKLEQV 1631
             |.|...|||                            ||.|.:::|..|.  |:.      .||
Zfish   926 -FASPNTEQTRRANQISKQELSCFLPDMHSHAQLFGNQAAFGNLSLGRLPK--GSK------SQV 981

  Fly  1632 DLFNACSQKLMMWQQQEEQRRSHPQQAQRLLKVEDH-----PQHSRDREQQ 1677
            .|.||.||..:     ..:.:.|.:..|..::|||.     ||.|...|.|
Zfish   982 FLKNAASQDAL-----RSEEKFHVRFLQESMQVEDQFDGVLPQTSHSLESQ 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nna1	NP_001285225.1	Pepdidase_M14_N	623..758	CDD:407865	69/134 (51%)
		M14_AGBL2-3_like	780..1031	CDD:349478	148/259 (57%)
agbl2	XP_073798308.1	None