Protein Alignment Nna1 and AGTPBP1

DIOPT Version :10

• Sequence 1: NP_001285225.1
• Gene: Nna1 / 32329
• FlyBaseID: FBgn0265726
• Length: 1890
• Species: Drosophila melanogaster
• Sequence 2: NP_001273644.1
• Gene: AGTPBP1 / 23287
• HGNCID: 17258
• Length: 1278
• Species: Homo sapiens
• Alignment Length: 1276
• Identity: 314/1276 - (24%)
• Similarity: 487/1276 - (38%)
• Gaps: 424/1276 - (33%)

  Fly     5 VKDKENRNSAMGPEICEV--------QQHPSKQNDGFLGSFLSKGLK--TN-------------- 45
            :|.|.|...|:.....:|        .:|.::..:..:...:.:.||  ||
Human   283 LKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSLKSVTNIKLGRKAFIDANGM 347

  Fly    46 QLVVNTDE-----KTLRPVARLKE-------PRDLFALPKDKDNDCSQQAPRWPVECQVIEERII 98
            :::.||.:     :||.|:.....       |::...||..|.:...|
Human   348 KILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSSFHFQ----------------- 395

  Fly    99 HIPYVPAVPEPLNAPTGNELKPRPVGEENGIVVFSYSPISAVNYEKPKAKKEDD-------ESSD 156
             :|.:|.        ||      ||.:     ::|..|  .|:....::...||       |:.:
Human   396 -LPVIPV--------TG------PVAQ-----LYSLPP--EVDDVVDESDDNDDIDVEAENETEN 438

  Fly   157 ESDYSSDSRQD--STPPSRSTPMRLAGGGECAPGKLNSVSKMINNVDNRSTSASLDDNDDYYDDE 219
            |.|...:.:.|  .|..::..|.:       .||:.....||..::    ....:||..||
Human   439 EDDLDQNFKNDDIETDINKLKPQQ-------EPGRTIEDLKMYEHL----FPELVDDFQDY---- 488

  Fly   220 YDTSGGYCGGSGEAKEKAIIKDLIEAKKKRYQEEAE-----VTPVGG----GTARNSR------- 268
                                 |||..:.|.:..|.:     |.|..|    |.:.|.|
Human   489 ---------------------DLISKEPKPFVFEGKVRGPIVVPTAGEETSGNSGNLRKVVMKEN 532

  Fly   269 -AASRSEASKDASDID----DIWKNN-TSEYKPASP-RYVLSQFGKN--VTKAVIDRIVDHEDLV 324
             ::...|..|.::.:|    ||..|: |.:.:|... |.:.|..|.|  :.|| :|||.
Human   533 ISSKGDEGEKKSTFMDLAKEDIKDNDRTLQQQPGDQNRTISSVHGLNNDIVKA-LDRIT------ 590

  Fly   325 PPSGSQKVSNQFAVG-------PVKLPKTNIARLEVAFERSAC-----QDRSKSRLKKKMSSSRR 377
                .|.:.:|.|.|       ...||.|.:...:.....:.|     :.|: .:|.|...:.
Human   591 ----LQNIPSQTAPGFTAEMKKDCSLPLTVLTCAKACPHMATCGNVLFEGRT-VQLGKLCCTG-- 648

  Fly   378 RRESTSDEDSSSSSLGNEEDEEVDDSDSDAENTGSGIGLRRILGSYSARLAGGAEKCPCPGSGSV 442
             .|:..|||:.|:|...:...||.|..:
Human   649 -VETEDDEDTESNSSVEQASVEVPDGPT------------------------------------- 675

  Fly   443 SDTETLVGDESRSRLAGSNGLHQQDVVCSRNRQAQS--------------------RSPLRSVPH 487
                                ||..|:.....:..:|                    :.|:...|:
Human   676 --------------------LHDPDLYIEIVKNTKSVPEYSEVAYPDYFGHIPPPFKEPILERPY 720

  Fly   488 THAATVAAAAAALARGRNRDKDGCLGGKDEKNMGMGVGTTGTSSMGTRTSSPVRNNVFRLSKDQH 552
                           |..|.|                               :..::.||.....
Human   721 ---------------GVQRTK-------------------------------IAQDIERLIHQSD 739

  Fly   553 ILLNSMTSQETTGTLISSTSTNQTTTTTNSSQSFLCSDLPQAQFSRSAVGGARFMTNCHPMNPEE 617
            |:                              ..:..||....::                .|||
Human   740 II------------------------------DRVVYDLDNPNYT----------------IPEE 758

  Fly   618 YDGLEFESRFESGNLAKAVQITPTYYELYLRPDLYTSRSKQWFYFRVRRTRRKMLYRFSIVNLVK 682
            .|.|:|.|:||||||.|.:||....|:|.|..|:.::...|||||.|...|..:.|||:|:|..|
Human   759 GDILKFNSKFESGNLRKVIQIRKNEYDLILNSDINSNHYHQWFYFEVSGMRPGVAYRFNIINCEK 823

  Fly   683 SDSLYNDGMQPVMYSTLGAKEKSEGWRRCGDNICYYRNDDESASSSANEDDEDNSTYTLTFTIEF 747
            |:|.:|.||||:|||...|......|.|.|.:||||:| ..|.||.|....:..|.||:|||:.|
Human   824 SNSQFNYGMQPLMYSVQEALNARPWWIRMGTDICYYKN-HFSRSSVAAGGQKGKSYYTITFTVNF 887

  Fly   748 EHDDDTVFFAHSYPYTYSDLQDYLMEIQ-RHPVKSKFCKLRLLCRTLAGNNVYYLTVTA-PSSNE 810
            .|.||..:||:.||||||.||.:|.::: .|..:..:.:..:||.||:||:...:|:|| |.||.
Human   888 PHKDDVCYFAYHYPYTYSTLQMHLQKLESAHNPQQIYFRKDVLCETLSGNSCPLVTITAMPESNY 952

  Fly   811 E----NMRRKKSIVVSARVHPSETPASWMMKGLMDFITGDTTVAKRLRHKFIFKLVPMLNPDGVI 871
            .    :.|.:..:.:||||||.||.|||:|||.::::..:...|:.||..:|||:||||||||||
Human   953 YEHICHFRNRPYVFLSARVHPGETNASWVMKGTLEYLMSNNPTAQSLRESYIFKIVPMLNPDGVI 1017

  Fly   872 VGNTRNSLTGKDLNRQYRTVIRETYPSIWYTK------AMIRRLIEECGVAMYCDMHAHSRKHNI 930
            .||.|.||:|:|||||:::...:.:|:|::.|      |.::||     ..:|||.|.||||.|:
Human  1018 NGNHRCSLSGEDLNRQWQSPSPDLHPTIYHAKGLLQYLAAVKRL-----PLVYCDYHGHSRKKNV 1077

  Fly   931 FIYGCENKR---NPEKKLTE---------QVFPLMLHKNSADRFSFESCKFKIQRSKEGTGRIVV 983
            |:|||..|.   :.....|.         :..|.:| .:.|..|...||.|.:::|||.|.|:||
Human  1078 FMYGCSIKETVWHTNDNATSCDVVEDTGYRTLPKIL-SHIAPAFCMSSCSFVVEKSKESTARVVV 1141

  Fly   984 WM-LGITNSYTIEASFGGSSLGSRKGTHFNTQDYEHMGRAFCETL---------LDYCDENPNKI 1038
            |. :|:..|||:|::..|...|..||....|::.|.||..||..|         |:|  ..|:.:
Human  1142 WREIGVQRSYTMESTLCGCDQGKYKGLQIGTRELEEMGAKFCVGLLRLKRLTSPLEY--NLPSSL 1204

  Fly  1039 LNLLKQQDRLRSKIIERLMREGS------SADEPLNIPLSDYSSDEGNCSSSSDNEGKHSITTSD 1097
            |:       ..:.:||...:..|      ..|||..:...|||::     |:.:.:.:.:....|
Human  1205 LD-------FENDLIESSCKVTSPTTYVLDEDEPRFLEEVDYSAE-----SNDELDIELAENVGD 1257

  Fly  1098 LEGPCCAPTRAPPSSPEVIHEIRKFRMRRMRKVMHELDRIY 1138
            .|         |.:..||:.:             .||.|.|
Human  1258 YE---------PSAQEEVLSD-------------SELSRTY 1276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nna1	NP_001285225.1	Pepdidase_M14_N	623..758	CDD:407865	62/134 (46%)
		M14_AGBL2-3_like	780..1031	CDD:349478	107/283 (38%)
AGTPBP1	NP_001273644.1	Pepdidase_M14_N	764..898	CDD:407865	62/134 (46%)
		M14_Nna1	921..1191	CDD:349477	106/275 (39%)