Protein Alignment Nna1 and LOC1269705

DIOPT Version :10

• Sequence 1: NP_001285225.1
• Gene: Nna1 / 32329
• FlyBaseID: FBgn0265726
• Length: 1890
• Species: Drosophila melanogaster
• Sequence 2: XP_061501591.1
• Gene: LOC1269705 / 1269705
• VectorBaseID: AGAMI1_015069
• Length: 1760
• Species: Anopheles gambiae
• Alignment Length: 1784
• Identity: 324/1784 - (18%)
• Similarity: 504/1784 - (28%)
• Gaps: 811/1784 - (45%)

  Fly   565 GTLISSTSTNQTTTTTNSSQSFLCSDLPQAQFSRSAVGGARFMTNCHPMNPEEYDGLEFESRFES 629
            |..:||.::......:.||.      :.....|.||:..|......|....:::.|| ..|...|
Mosquito    43 GNTVSSGTSGVPVIGSGSSA------IGPGSTSASAIVAATLGIGLHQQQQQQHHGL-LSSVSGS 100

  Fly   630 GNLAKAVQITP--------------------------TYYELYLRPDL----YTSRSKQWFYFRV 664
            |:.|    .||                          ..:.|:.|||.    |.::::.||:|.|
Mosquito   101 GSAA----ATPGANAGGSLGMPIPSPTPHATENPLVEVEFNLWTRPDCAGTPYENQNRTWFHFAV 161

  Fly   665 RRTRRKMLYRFSIVNLVKSDSLYNDGMQPVMYSTLGAKEKSEGWRRCGDNICYYRNDDESASSSA 729
            ...|...:.:|:::||.|...|::.||.||  :.:|...:   |.|.
Mosquito   162 TGGRPNQIVKFNVMNLNKQAKLFSQGMHPV--TKVGPNGR---WERI------------------ 203

  Fly   730 NEDDEDNSTYTLT---FTIEFEH-------DDDTVFFAHSYPYTYSDLQDYLMEIQ----RHPV- 779
                :|..:|::|   |.|.|.|       |...:::|.::|:||::|.|.|....    |||.
Mosquito   204 ----KDKPSYSITNDVFFISFLHKVPEVGGDTTRIYYAFTFPFTYTELMDQLSTFDRKYGRHPFE 264

  Fly   780 ----------------------------------KSKFCKLRLLCRTL----------------- 793
                                              |.|..|:..:.||.
Mosquito   265 LHKMAYDISQKYDSLPATAAEESKNISNLAPHRRKGKLSKMERVDRTSPESFDETARDGVGEGSP 329

  Fly   794 ---------------------AG------------------------------------------ 795
                                 ||
Mosquito   330 PGKEVLAEAAKSLQTVLGPGGAGGMVIDENTSESMQQITNLVNKVKIELPQGGGGEMKQPAQQAS 394

  Fly   796 ----------------------------------------NNVYY----------------LTV- 803
                                                    :.:||                ||:
Mosquito   395 SSASATKAKLPSFHHQLNVASAVAAAANPSPEDDQKADPRDEIYYCRELLTHSIEHRRIELLTIS 459

  Fly   804 ------TAPSSNEENM------------RRKKSIVVSARVHPSETPASWMMKGLMDFITG-DTTV 849
                  ||..:...|:            |.||.:.:|:||||.|||||:::.|.:..:.. .:.|
Mosquito   460 SFHGIQTARETRLRNLFPDEAAQRCHTFREKKIVFISSRVHPGETPASFVLNGFLSMLLDRKSIV 524

  Fly   850 AKRLRHKFIFKLVPMLNPDGVIVGNTRNSLTGKDLNRQYRTVIRETYPSIWYTKAMIRRLIEECG 914
            ::.||..::||::|.||||||..|..|:...|.:|||.|.:...||.|:|:..:.:||
Mosquito   525 SQTLRRMYVFKIIPFLNPDGVYNGLYRSDTRGHNLNRVYISPCHETQPAIYAARKLIR------- 582

  Fly   915 VAMYCDMHAHSRKHNIFIYGCENKRNPEKKLTEQVFPLMLHKNSADRFSFESCKFKIQRSKEGTG 979
                   :.|.....:..|..|.::.              |.:.             :.|||.
Mosquito   583 -------YYHLGVDEVESYELEKEKE--------------HAHG-------------EGSKEA-- 611

  Fly   980 RIVVWMLGITNSYTIEASFGGSSLGSRKGTHFNTQDYEHMGRAFCETLLDYCDENPNKILNLLKQ 1044
                  :|:.:..:...:..||:                           ..|.:...:...||:
Mosquito   612 ------IGVVDPESATPAGEGSA---------------------------PVDSSGGNVKMALKK 643

  Fly  1045 QDRLRS--------KIIERLMREGSSADEPLNIPLSDYSS-----DEGNCSSSSDNEGKHSITTS 1096
            ..||.|        .|.:|.....||..:|.....|:..|     .....::|..|..|.:|:.|
Mosquito   644 VKRLSSTMSLPVDGSIRKRRTPSLSSTPQPTVSVASERRSVIAFVTPAEPAASLSNRAKSTISPS 708

  Fly  1097 DLEGPCCAPTRAPPSSPEVIHEIRKFRMRRMRKVMHELDRIYFTPLFQRKFKTLTTLKRRRQKMG 1161
            .......|..     |.:::.:|                                 |:|||.|.|
Mosquito   709 SSSSSSSASW-----SDKLLGKI---------------------------------LRRRRAKAG 735

  Fly  1162 VKAAPSGKRLRGGGGPAVS---AATPTPAPAVQAAAPVVETNDVQKLHTPRQLARSLPSNSD--- 1220
            .    ||..:..|.|..:|   .|.|.|...:.|.|....|:..::  .....|:|.||:.:
Mosquito   736 A----SGAAVSAGSGAKLSPIAQALPKPTLVLPAVAEEESTSTAEE--PALSAAKSSPSSPELVS 794

  Fly  1221 QPTG-----------GQSSDSSESMDSSQSESLLEPD-GSSGSTAASKEVTKKVKTSGAGTKKTA 1273
            .|||           ..||..::..||.:.::....| |.|.:::.|..:|.||.:|.|
Mosquito   795 SPTGLTNANTTTTASVASSPLTDESDSVEQDTPAASDSGFSEASSTSSSLTSKVASSAA------ 853

  Fly  1274 KKKKFMPTEKKKPVVNQKLHVDRNFRLWLANRRIYIYRRKKSTQARRTKVRNKPSKKRGEVVRTT 1338
                 :||:
Mosquito   854 -----LPTQ-------------------------------------------------------- 857

  Fly  1339 LDLPTTDPGSDLHFSTDDEEHSPTSGHNGYGAVPPLRHTLLQSDLQRRYIEEIGDTVVQK----- 1398
                          |:.|...||.:..:...||.|      .:.:|.:.:.....|..|.
Mosquito   858 --------------SSADSTGSPPTADSTPAAVVP------AAVVQPQSLVAAATTAAQVFTEKL 902

  Fly  1399 -PKASHMPPELIVTTPSKS---------GTPGG--GKKLDVYKLTPRTAPELDTGIGMMQRQAGG 1451
             |:.:.:..|...||.|.|         ||.||  ...|.:.|.......::|||       .||
Mosquito   903 IPELNPIVSEGTATTASSSNNLAPATVRGTAGGRSASSLSLKKSIHSVTAKVDTG-------KGG 960

  Fly  1452 TGTSARRTYSWHNLDQQEIPNGNGGGQGKANFYIGDTKPGIKTMAKPLPRRSVPSNFIPQRH--- 1513
            .|.||.  :..|.|::.:              ::|.| ||.....:.|..        |..|
Mosquito   961 IGKSAH--HKQHVLNKPQ--------------FLGAT-PGTLKFKEFLVH--------PHHHHHH 1000

  Fly  1514 -----------------GNVQTADDLQLKLSLKKKVWTG----ANGDADGRPLAW---------- 1547
                             |.|               ..||    |.|:|.|:.:|.
Mosquito  1001 HHHHHHHHHYLAGGGAAGGV---------------AGTGGAMSAGGNAQGQVVATLHGGKMALGA 1050

  Fly  1548 YKGHSITASQMANTTTTIRSAGGGAAGGGGAGAGAGAGGGG---GGQNRNMFPSNGREQ------ 1603
            :|..|....|.|.:::|....|.|.||......|...|.||   ||:||...|.....|
Mosquito  1051 FKKGSAGGKQQATSSSTSSLIGVGGAGRASGSGGTVLGDGGTTVGGKNRPQTPQTNAAQYSHYRS 1115

  Fly  1604 --------TAASGGIAMGVP--------------------------------------------- 1615
                    ....||:. |||
Mosquito  1116 HRNEYLNPVMGGGGVG-GVPRSLNISLDFLAQLDERHDRVVYEDRSNLFMYIDLHGHASKKGVFM 1179

  Fly  1616 -----PAFVGA------PRRVRKLEQVDLFNAC--SQKLMMWQ------QQEEQRRSHPQQAQRL 1661
                 |:.|.|      ||.:....|...|:||  |::.|.::      .:|...|....::..|
Mosquito  1180 YGNHLPSTVEAVECMLLPRLMSLNSQHFHFDACNFSERNMYYKGKRDGLSKEGSGRVAVYKSTGL 1244

  Fly  1662 LK---VEDHPQHSRDREQQPFKPMHVVRKSTGTTSQAKVIQALVAAESGGK-------------- 1709
            :|   :|.:....:.....|.:...:|.|:|.|....|...|:.  |..||
Mosquito  1245 IKSYTLECNYNTGKCVNILPPRGKEIVAKTTHTLVPPKYTPAVF--EEVGKALGPSILDLTNSNP 1307

  Fly  1710 ----------------------VKRKSSSMMKIAETTQLVTRFARNRNSAGGSAAQQQQQQQPPQ 1752
                                  ::|.||......:|.:..|:...|:.|.....|::...|
Mosquito  1308 LSRLPNCEFRTLQGLRNALRIEIERGSSKARVTNKTQKSHTKRLANQLSCSIDVAKENAIQ---- 1368

  Fly  1753 HMHHQHKRLLFKGQGGVGAMGSRMHSAGVMG-------NMQGN---------GGGRAPNKFKTGG 1801
               ..|.    .|...||..|......||.|       .|.|:         |||
Mosquito  1369 ---WDHS----LGAPVVGVAGGAGQQTGVPGPTVAVASKMVGDPDAATLLLAGGG---------- 1416

  Fly  1802 LVITAVQQPTNMTGGGSRRMRNAAGLQAKGSNGALGSSTGQMQYQRSNAS-----------VQAN 1855
                         ||||           .|::||.|:.:.|...|...||           |.|.
Mosquito  1417 -------------GGGS-----------SGASGATGAGSTQHPRQVLKASGSSVTLKTTHVVGAG 1457

  Fly  1856 KSATEISMDAVSLVRKVKTKLKKRKSRTL 1884
            .:..:||       |||....|.:||:.|
Mosquito  1458 GAGGKIS-------RKVGAFGKPKKSKVL 1479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nna1	NP_001285225.1	Pepdidase_M14_N	623..758	CDD:407865	36/174 (21%)
		M14_AGBL2-3_like	780..1031	CDD:349478	63/406 (16%)
LOC1269705	XP_061501591.1	None