DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nadsyn and Nadsyn1

DIOPT Version :9

Sequence 1:	NP_001285224.1	Gene:	Nadsyn / 32328	FlyBaseID:	FBgn0030512	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_084497.1	Gene:	Nadsyn1 / 78914	MGIID:	1926164	Length:	725	Species:	Mus musculus

Alignment Length:	732	Identity:	436/732 - (59%)
Similarity:	542/732 - (74%)	Gaps:	16/732 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRKVTVAVSTLNQWALDFEGNMVRILQSILEAKDMGASYRTGPELEVCGYSCEDHFREPDTFLH 65
            ||||||||...|||||||||||..|||:||..||..||.||.|||||:|||.|.||:.|.||.||
Mouse     1 MGRKVTVATCALNQWALDFEGNFQRILKSIQIAKGKGARYRLGPELEICGYGCWDHYHESDTLLH 65

  Fly    66 SWEVLLEVMMSPMCENMLVDVGMPVMHRNVAYNCRVAFFNRQILLIRPKMAMCDDGNYRESRWFT 130
            |.:||..::.||:.::::.|||||:|||||.|||||.|.||:|||||||||:.::|||||.||||
Mouse    66 SLQVLAALLDSPVTQDIICDVGMPIMHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFT 130

  Fly   131 AWTKALQTEEYVLPRMIAQHTGQQTVPFGDAVIATRDTCLGYEICEELWNVRSKHIEMSLAGVEL 195
            .||::.||||||||||:...|.|:||||||.|:||:|||:|.|||||||..||.||:|.|.|||:
Mouse   131 PWTRSRQTEEYVLPRMLQDLTKQKTVPFGDVVLATQDTCVGSEICEELWTPRSPHIDMGLDGVEI 195

  Fly   196 IVNSSGSYMELRKAHITSDLIRNASFKAGGAYLFSNLRGCDGQRVYFNGCSAIALNGEILARSQQ 260
            |.|:|||:..|||||...||:..|:.|.||.||.:|.:||||.|:|::||:.||:||.|.|:..|
Mouse   196 ITNASGSHHVLRKAHTRVDLVTMATSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSIFAQGTQ 260

  Fly   261 FALQDVEVTLATIDLEEIRAYRVSLRSRCTAAASAAEYPRIHCDFEMSTHSDIFKTSTPPLNWPM 325
            |:|.||||..||:|||::|:|:..:.||...|...:.|||:..||.:|...|:.:..:.|:.|..
Mouse   261 FSLDDVEVLTATLDLEDVRSYKAEISSRNLEATRVSPYPRVTVDFALSVSEDLLEPVSEPMEWTY 325

  Fly   326 HTPEEEIALGPACWLWDYLRRSGQGGFFLPLSGGVDSSSSATIVHSMCRQIVQAVQQGDAQVLHD 390
            |.|||||:|||||||||:||||.|.||||||||||||::||.||:|||..:..||:.|:.|||.|
Mouse   326 HRPEEEISLGPACWLWDFLRRSKQAGFFLPLSGGVDSAASACIVYSMCCLVCDAVKSGNQQVLTD 390

  Fly   391 IRQLLADSDYTPDNAAGLCNRLLVTCYMGSVNSSKETRRRAAQLANQLGSYHIEISIDSAVNALL 455
            ::.|:.:|.|||.:...||.|||.||||.|.|||:||..||.:||..:|||||.:|||:||.|:|
Mouse   391 VQNLVDESSYTPQDPRELCGRLLTTCYMASENSSQETHSRATKLAQLIGSYHINLSIDTAVKAVL 455

  Fly   456 SIFNAVTGLTPRFRTQGGCARQNLALQNMQSRIRMVLAYIFAQLTLWVRNRPGGLLVLGSANVDE 520
            .||:.:||..|||...||.:|:||||||:|:||||||||:||||:||.|...|.|||||||||||
Mouse   456 GIFSLMTGKLPRFSAHGGSSRENLALQNVQARIRMVLAYLFAQLSLWSRGARGSLLVLGSANVDE 520

  Fly   521 SLRGYLTKYDCSSADINPIGGISKMDLRRFLTYAKDKFNLPVLESIIDAPPTAELEPLQENGELQ 585
            ||.|||||||||||||||||||||.|||.|:.:..::|.||||::|:.||.|||||||.: |::.
Mouse   521 SLLGYLTKYDCSSADINPIGGISKTDLRAFVQFCAERFQLPVLQTILSAPATAELEPLAD-GQVS 584

  Fly   586 QTDEADMGMTYAELSQFGRLRKQSFCGPYSMFCHLVATWKSDLSPKEVAEKVKHFFLCYAINRHK 650
            |.||.||||||||||.||||||.:..|||||||.|:..|:...:|.:||||||.||..|::||||
Mouse   585 QMDEEDMGMTYAELSIFGRLRKVAKAGPYSMFCKLLNMWRDSYTPTQVAEKVKLFFSKYSMNRHK 649

  Fly   651 MTVLTPSVHAESYSPDDNRFDHRPFLYRPNWSWQFKAIDDEAEKLQPIYTPSSAQLRPSSEDLLI 715
            ||.|||:.|||:|||||||||.|||||...|.|||..||::..:|:          |.:|:
Mouse   650 MTTLTPAYHAENYSPDDNRFDLRPFLYNTRWPWQFLCIDNQVLQLE----------RKASQ---- 700

  Fly   716 STQRSSHLDDSKHSSPL 732
             |:....|:..|..||:
Mouse   701 -TREEQVLEHFKEPSPI 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nadsyn	NP_001285224.1	PLN02339	3..695	CDD:177973	426/691 (62%)
Nadsyn1	NP_084497.1	PLN02339	3..697	CDD:177973	427/704 (61%)
		GAT_Gln-NAD-synth	6..287	CDD:143594	172/280 (61%)
		Ligase. /evidence=ECO:0000250	325..706		243/396 (61%)
		NAD_synthase	328..650	CDD:238309	209/322 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835164
Domainoid	1	1.000	369	1.000	Domainoid score	I913
eggNOG	1	0.900	-	-		E1_COG0171
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6098
Inparanoid	1	1.050	892	1.000	Inparanoid score	I388
Isobase	1	0.950	-	0	Normalized mean entropy	S353
OMA	1	1.010	-	-		QHG54707
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004683
OrthoInspector	1	1.000	-	-		oto95272
orthoMCL	1	0.900	-	-		OOG6_100679
Panther	1	1.100	-	-	LDO	PTHR23090
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R791
SonicParanoid	1	1.000	-	-		X3872
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.780