Protein Alignment Nadsyn and NADSYN1

DIOPT Version :10

• Sequence 1: NP_572913.1
• Gene: Nadsyn / 32328
• FlyBaseID: FBgn0030512
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_060631.2
• Gene: NADSYN1 / 55191
• HGNCID: 29832
• Length: 706
• Species: Homo sapiens
• Alignment Length: 712
• Identity: 420/712 - (58%)
• Similarity: 538/712 - (75%)
• Gaps: 9/712 - (1%)

  Fly     1 MGRKVTVAVSTLNQWALDFEGNMVRILQSILEAKDMGASYRTGPELEVCGYSCEDHFREPDTFLH 65
            ||||||||...|||||||||||:.|||:||..||:.||.||.|||||:|||.|.||:.|.||.||
Human     1 MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLH 65

  Fly    66 SWEVLLEVMMSPMCENMLVDVGMPVMHRNVAYNCRVAFFNRQILLIRPKMAMCDDGNYRESRWFT 130
            |::||..::.||:.::::.|||||||||||.|||||.|.||:|||||||||:.::|||||.||||
Human    66 SFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFT 130

  Fly   131 AWTKALQTEEYVLPRMIAQHTGQQTVPFGDAVIATRDTCLGYEICEELWNVRSKHIEMSLAGVEL 195
            .|:::..||||.|||||...|.|:||||||||:.|.|||:|.|||||||...|.||:|.|.|||:
Human   131 PWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWTPHSPHIDMGLDGVEI 195

  Fly   196 IVNSSGSYMELRKAHITSDLIRNASFKAGGAYLFSNLRGCDGQRVYFNGCSAIALNGEILARSQQ 260
            |.|:|||:..||||:...||:...:.|.||.||.:|.:||||.|:|::||:.||:||.:.|:..|
Human   196 ITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQ 260

  Fly   261 FALQDVEVTLATIDLEEIRAYRVSLRSRCTAAASAAEYPRIHCDFEMSTHSDIFKTSTPPLNWPM 325
            |:|.||||..||:|||::|:||..:.||..||:.|:.|||:..||.:|.|.|:....:.|:.|..
Human   261 FSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKY 325

  Fly   326 HTPEEEIALGPACWLWDYLRRSGQGGFFLPLSGGVDSSSSATIVHSMCRQIVQAVQQGDAQVLHD 390
            |:|||||:|||||||||:||||.|.||.|||||||||:::|.:::|||.|:.:||:.|:.:||.|
Human   326 HSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGVDSAATACLIYSMCCQVCEAVRSGNEEVLAD 390

  Fly   391 IRQLLADSDYTPDNAAGLCNRLLVTCYMGSVNSSKETRRRAAQLANQLGSYHIEISIDSAVNALL 455
            :|.::....|||.:...||.|:|.||||.|.|||:||..||.:||.|:||:||.::||.||.|::
Human   391 VRTIVNQISYTPQDPRDLCGRILTTCYMASKNSSQETCTRARELAQQIGSHHISLNIDPAVKAVM 455

  Fly   456 SIFNAVTGLTPRFRTQGGCARQNLALQNMQSRIRMVLAYIFAQLTLWVRNRPGGLLVLGSANVDE 520
            .||:.|||.:|.|...||.:|:||||||:|:||||||||:||||:||.|...|||||||||||||
Human   456 GIFSLVTGKSPLFAAHGGSSRENLALQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDE 520

  Fly   521 SLRGYLTKYDCSSADINPIGGISKMDLRRFLTYAKDKFNLPVLESIIDAPPTAELEPLQENGELQ 585
            ||.|||||||||||||||||||||.|||.|:.:...:|.||.|:||:.||.|||||||.: |::.
Human   521 SLLGYLTKYDCSSADINPIGGISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLAD-GQVS 584

  Fly   586 QTDEADMGMTYAELSQFGRLRKQSFCGPYSMFCHLVATWKSDLSPKEVAEKVKHFFLCYAINRHK 650
            ||||.||||||||||.:|:|||.:..|||||||.|:..|:...:|::||:|||.||..|::||||
Human   585 QTDEEDMGMTYAELSVYGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHK 649

  Fly   651 MTVLTPSVHAESYSPDDNRFDHRPFLYRPNWSWQFKAIDDEAEKLQPIYTPSSAQLRPSSED 712
            ||.|||:.|||:|||:|||||.|||||..:|.|||:.|:::..:|:        :..|.|.|
Human   650 MTTLTPAYHAENYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLE--------RAEPQSLD 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nadsyn	NP_572913.1	PLN02339	3..695	CDD:177973	414/691 (60%)
NADSYN1	NP_060631.2	PLN02339	3..699	CDD:177973	415/704 (59%)
		Ligase. /evidence=ECO:0000250	325..706		232/388 (60%)