DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12177 and URH1

DIOPT Version :9

Sequence 1:	NP_001285222.1	Gene:	CG12177 / 32326	FlyBaseID:	FBgn0030510	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_010688.4	Gene:	URH1 / 852009	SGDID:	S000002808	Length:	340	Species:	Saccharomyces cerevisiae

Alignment Length:	362	Identity:	95/362 - (26%)
Similarity:	154/362 - (42%)	Gaps:	86/362 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LDCDGGSDDAWALLL-LLHAAKSHGIHLLAITTMGC-GNTSRENAARNMRRILDAC-KRTDIPIY 90
            ||||.|.|||.|:|| ..|.|    .:||.|:|  | ||...||...|.|.:|.|. |...||:|
Yeast    10 LDCDPGHDDAIAILLGCFHPA----FNLLGIST--CFGNAPPENTDYNARSLLTAMGKAQAIPVY 68

  Fly    91 LGAVDALIPSLEDEKKY---FHGRDGFGDCLTDDCALQLEDIVQA---EHAVTAIHDLCRSRPKQ 149
            .||.    ...:.|..|   .||..|.     |..:|..:...:|   :..:.||.:...:...:
Yeast    69 KGAQ----RPWKREPHYAPDIHGISGL-----DGTSLLPKPTFEARTDKTYIEAIEEAILANNGE 124

  Fly   150 ITIFAVGPLTNLALGYTMY--GPEFGNNFRDLFIMGGNYQGVG--NSSRSAEFNFHSDPEAAHTV 210
            |:..:.|.||.||   |::  .|....:.:.:.||||...|:|  |.:.|||||...||:||:.:
Yeast   125 ISFVSTGALTTLA---TVFRCKPYLKKSVKYISIMGGGLHGLGNCNPNLSAEFNVWIDPDAANYI 186

  Fly   211 L----LRTRC---PITILPWEACLPERFNIHI-----NWRLKD--------FAARAK-----EAG 250
            .    ::.:|   |:. |..:|....:.|..|     |.:|::        ||...|     |:|
Yeast   187 FRDPDVKDKCIVVPLN-LTHKAIATYKVNEMIYNEKNNSKLRELFLELFQFFAHTYKDMQGFESG 250

  Fly   251 HPAITMLNQVEAAQWLPMIEQYGIDTWNPCDAIAVAVWLFEDHLIRRHNTWHATVDLRGTHTRGQ 315
            .|.      .:....:|::|.||   |:|..|:.          .|......:.:|.......|:
Yeast   251 PPI------HDPVALMPLLEFYG---WDPSSAVG----------FRYKRMDISCIDDVFNENSGK 296

  Fly   316 MVLDHLREREKYPENVRIIELVDVE-----FFKRICE 347
            ::::     ::||.:..:..::.::     |:.:|.|
Yeast   297 IIIE-----KEYPNDSDVGTIIGLDLNIQYFWDQIFE 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12177	NP_001285222.1	nuc_hydro_CeIAG	25..347	CDD:239115	94/360 (26%)
URH1	NP_010688.4	nuc_hydro_IU_UC_XIUA	7..330	CDD:239117	95/362 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	65	1.000	Domainoid score	I2406
eggNOG	1	0.900	-	-		E1_COG1957
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	65	1.000	Inparanoid score	I1738
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001175
OrthoInspector	1	1.000	-	-		otm46652
orthoMCL	1	0.900	-	-		OOG6_100640
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16688
SonicParanoid	1	1.000	-	-		X724
TreeFam	1	0.960	-	-
	11	10.750