DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11164 and rnaseh2b

DIOPT Version :9

Sequence 1:	NP_001285220.1	Gene:	CG11164 / 32323	FlyBaseID:	FBgn0030507	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_021334305.1	Gene:	rnaseh2b / 393241	ZFINID:	ZDB-GENE-040426-1090	Length:	306	Species:	Danio rerio

Alignment Length:	348	Identity:	104/348 - (29%)
Similarity:	161/348 - (46%)	Gaps:	62/348 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TRARKPKADPDAEGSAKMCKASAL---KKVFFMSEELLPKDADDGHLRLEMFFHPGHGKEALFIT 67
            |..:|..|..:::....:...|||   :.|          |:|...::|:   :|..|..:|::.
Zfish     2 TSKKKRSAHTESDSWVVIAPDSALDTGRSV----------DSDPSFIKLK---NPSTGSSSLYLF 53

  Fly    68 H-PDGRMMELVAFTEPRRSWFVDSEVCSNGRIYMTAPVDPTFLALHHLR------KHCAQRAISL 125
            . .|..:.|:.||:|..||||:...|..:||:....|:||.||.|.::.      |..:.:.:.:
Zfish    54 GCGDLSVYEVKAFSEDFRSWFIGQTVQRDGRLLYVTPMDPLFLLLPYISSVGKEGKFQSVKQMVM 118

  Fly   126 DNIAVEEASTSRLL--NEILDPGNLKCVADVKSSGEQKFYKYNQERTLAWLALKTRQVAKILKEK 188
            |.   :....||||  .:.||  :|..|||.|...:||::|||.|:||.||..|.::....||:.
Zfish   119 DE---DYPGCSRLLQCKQGLD--SLHHVADEKEVNDQKYHKYNLEKTLEWLKKKVQRTVNALKKG 178

  Fly   189 QVHCGHSAQSQNFVRSEKLVAENVSNEMDYTRMACDYVGRYLDADLHGLLTSYLHIPSEIQAIVE 253
            .:..|...:|..|||    |....::|.||.|.|...:..|:..||...|..:|.:| ||.:..|
Zfish   179 NISVGGGVKSSTFVR----VKHEDASEEDYLRYAHGLISEYISEDLSKDLLKHLELP-EISSPKE 238

  Fly   254 EKAASQKRKSVAGKNEGSDSKKIKLNESDAAAKLKSSGLVDSDGDPNATITSPTAAPLKERSLTA 318
            .:..|:||| ::.|...:.....|.|.:|.|.|                       |.|:  :||
Zfish   239 AEPPSKKRK-LSDKPVEAGEDYTKFNSADFARK-----------------------PPKK--MTA 277

  Fly   319 KEKALAKGAK-GTKSIASFFKAK 340
            .:|:|||..| |.||:||||..|
Zfish   278 AQKSLAKADKTGMKSLASFFSPK 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11164	NP_001285220.1	RNase_H2-B	39..338	CDD:187751	95/308 (31%)
rnaseh2b	XP_021334305.1	RNase_H2-Ydr279	17..297	CDD:312838	98/328 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594184
Domainoid	1	1.000	60	1.000	Domainoid score	I10590
eggNOG	1	0.900	-	-		E1_KOG4705
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41572
Inparanoid	1	1.050	114	1.000	Inparanoid score	I4814
OMA	1	1.010	-	-		QHG59373
OrthoDB	1	1.010	-	-		D1092212at2759
OrthoFinder	1	1.000	-	-		FOG0005677
OrthoInspector	1	1.000	-	-		oto38960
orthoMCL	1	0.900	-	-		OOG6_104396
Panther	1	1.100	-	-	LDO	PTHR13383
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6122
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770