DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNAlig4 and DNL4

DIOPT Version :9

Sequence 1:NP_572907.1 Gene:DNAlig4 / 32322 FlyBaseID:FBgn0030506 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_014647.1 Gene:DNL4 / 854166 SGDID:S000005531 Length:944 Species:Saccharomyces cerevisiae


Alignment Length:1039 Identity:247/1039 - (23%)
Similarity:408/1039 - (39%) Gaps:237/1039 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 DIASTIKFRDIC-SLFEKIKATQ----KVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGA 63
            :.|.:..|:.:| .||.||...|    ....|....| |||......|.:|:..|.|        
Yeast    13 NFAPSPDFKWLCEELFVKIHEVQINGTAGTGKSRSFK-YYEIISNFVEMWRKTVGNN-------- 68

  Fly    64 SSFYSVLRLLLPGADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIRLQH------RNGNMYRDY 122
              .|..|.|.||..|  |..|.::...|.|.....|:||.:|:...||:.      :.||:    
Yeast    69 --IYPALVLALPYRD--RRIYNIKDYVLIRTICSYLKLPKNSATEQRLKDWKQRVGKGGNL---- 125

  Fly   123 GDVVYSVLKPRCFNPPSN-LRLKEIHQMLDTIANE--------DTEVKQQQLIRFTEQASPEEQK 178
            ..::...:..|...|.|. :.:..::..||:::.:        .:.||.:..:...|..|..|.|
Yeast   126 SSLLVEEIAKRRAEPSSKAITIDNVNHYLDSLSGDRFASGRGFKSLVKSKPFLHCVENMSFVELK 190

  Fly   179 WLIRLLLKSLGLGIGEQKIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKF 243
            :...::||:..:|..|.|:....||.|||.....|||..|.:.|.|....|     ||...::|.
Yeast   191 YFFDIVLKNRVIGGQEHKLLNCWHPDAQDYLSVISDLKVVTSKLYDPKVRL-----KDDDLSIKV 250

  Fly   244 -----------VNLN--SVIRPFHQIRPMLCERFPGDIQELMQSDVLYLETKMDGERFQLH-IDR 294
                       |||:  .:.|..|                    |...:|.||||||.|:| ::.
Yeast   251 GFAFAPQLAKKVNLSYEKICRTLH--------------------DDFLVEEKMDGERIQVHYMNY 295

  Fly   295 GR-FMYISRNGVDYTRNFGHSYDHGTLTPKLRGLLPLGLESIILDGEMMVWDTNK---LRF-REK 354
            |. ..:.||.|:|||..:|.|...||::..||  ....::..:|||||:.:|..:   |.| ..|
Yeast   296 GESIKFFSRRGIDYTYLYGASLSSGTISQHLR--FTDSVKECVLDGEMVTFDAKRRVILPFGLVK 358

  Fly   355 GENTDVKSLKPEGS--WQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQSGVLQLMRARKI 417
            |...:..|.....:  :.|.::|:||||.||.||......||...|..::.....:::::|:.:.
Yeast   359 GSAKEALSFNSINNVDFHPLYMVFDLLYLNGTSLTPLPLHQRKQYLNSILSPLKNIVEIVRSSRC 423

  Fly   418 GSVQEFNELFQQALDSHAEGIVLKKQGSRYQPGVRLGGGWYKDKADYIKGLITEFDVLIIGAFYN 482
            ..|:...:..:.|:...:||:|||...|.|....| ...|.|.|.:|::......|:::||....
Yeast   424 YGVESIKKSLEVAISLGSEGVVLKYYNSSYNVASR-NNNWIKVKPEYLEEFGENLDLIVIGRDSG 487

  Fly   483 RKRTFVDSFLLGVL----------------------QPAPPGSSNR--PEVFSIGVVANNTKQRG 523
            :|    |||:||:|                      |.....:|.|  .::.|...:||...|..
Yeast   488 KK----DSFMLGLLVLDEEEYKKHQGDSSEIVDHSSQEKHIQNSRRRVKKILSFCSIANGISQEE 548

  Fly   524 V--LNHTLKPHWHDVVNEPPP---LWFHYKPKERSGCPDLWIEPQNSVILQVKAADLAPNGA--- 580
            .  ::...:.||.......||   |.|..|      .|..||:|..|::|::|:..|.....   
Yeast   549 FKEIDRKTRGHWKRTSEVAPPASILEFGSK------IPAEWIDPSESIVLEIKSRSLDNTETNMQ 607

  Fly   581 -FFTRKSLHFPRTEMKRDDKTWSECMTLKEFNDLCGGPLAIKKLNKRQLRLEDVTTKRKQMRMTP 644
             :.|..:|:....:..|.||.|::|.||   |||                     .:.:.::..|
Yeast   608 KYATNCTLYGGYCKRIRYDKEWTDCYTL---NDL---------------------YESRTVKSNP 648

  Fly   645 S---ERSRLGLAVYEKRYDASTSAS---------TSKLFDGLSFCILS-----GSAGRHSKHQLQ 692
            |   |||:||| :.:||.....|.|         .|.:|.||.|.:||     .:..|.::.:|:
Yeast   649 SYQAERSQLGL-IRKKRKRVLISDSFHQNRKQLPISNIFAGLLFYVLSDYVTEDTGIRITRAELE 712

  Fly   693 ELAVKNGGCIVENPL-----PNDPKCFCIAGDETFLVKRLILQQPRTCDIVRMEWLLR-VCQKQE 751
            :..|::||.::.|.:     ..|.:  .|:...|...|.||   .|..||:...|:|. :..|:.
Yeast   713 KTIVEHGGKLIYNVILKRHSIGDVR--LISCKTTTECKALI---DRGYDILHPNWVLDCIAYKRL 772

  Fly   752 LELKPRDLIAATEPLQQDLAECFDRHGDSYTKDIANVEELQDLLQGIELTADNVAGITASNLNAL 816
            :.::|......::.::....:..|..|||:..||:.. :|..|.:         :.::...:..|
Yeast   773 ILIEPNYCFNVSQKMRAVAEKRVDCLGDSFENDISET-KLSSLYK---------SQLSLPPMGEL 827

  Fly   817 EDQLLDGK-KNLNMFRNLNAFFYSPH-----GDEVAKLLFLQNGGRIVDD-----------SDPQ 864
            |   :|.: :...:|...|...|.|.     .|::.::.....||:|.|.           :||.
Yeast   828 E---IDSEVRRFPLFLFSNRIAYVPRRKISTEDDIIEMKIKLFGGKITDQQSLCNLIIIPYTDPI 889

  Fly   865 LNLGFICMSSDIDNDHFEHWLHNHSKLTTD-----------KVLNSAWIHQCHREGILLPMHSF 917
            |...  ||:            ..|.|:...           :|:...|:.....|...:|...|
Yeast   890 LRKD--CMN------------EVHEKIKEQIKASDTIPKIARVVAPEWVDHSINENCQVPEEDF 939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNAlig4NP_572907.1 DNA_ligase_A_N 10..197 CDD:282522 49/206 (24%)
dnl1 84..613 CDD:273147 151/597 (25%)
Adenylation_DNA_ligase_IV 249..466 CDD:185713 64/224 (29%)
OBF_DNA_ligase_IV 469..607 CDD:153437 39/170 (23%)
BRCT 668..745 CDD:214602 23/86 (27%)
DNL4NP_014647.1 DNA_ligase_A_N 20..207 CDD:282522 48/203 (24%)
dnl1 84..717 CDD:273147 174/699 (25%)
Adenylation_DNA_ligase_IV 244..471 CDD:185713 68/249 (27%)
OBF_DNA_ligase_IV 474..635 CDD:153437 39/170 (23%)
BRCT 681..767 CDD:278934 24/90 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157346790
Domainoid 1 1.000 86 1.000 Domainoid score I1881
eggNOG 1 0.900 - - E1_COG1793
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1736
Inparanoid 1 1.050 168 1.000 Inparanoid score I1023
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54896
OrthoFinder 1 1.000 - - FOG0004767
OrthoInspector 1 1.000 - - oto99807
orthoMCL 1 0.900 - - OOG6_103257
Panther 1 1.100 - - LDO PTHR45997
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R326
SonicParanoid 1 1.000 - - X3920
TreeFam 1 0.960 - -
1514.790

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