Protein Alignment DNAlig4 and CDC9

DIOPT Version :10

• Sequence 1: NP_572907.1
• Gene: DNAlig4 / 32322
• FlyBaseID: FBgn0030506
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_010117.1
• Gene: CDC9 / 851391
• SGDID: S000002323
• Length: 755
• Species: Saccharomyces cerevisiae
• Alignment Length: 675
• Identity: 159/675 - (23%)
• Similarity: 270/675 - (40%)
• Gaps: 166/675 - (24%)

  Fly     6 ASTIKFRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGASSFYSVL 70
            :|.|.:.::|.:|.||:|   ::::.|:::...:.|.:    ..:|:..|
Yeast   143 SSNIPYSEVCEVFNKIEA---ISSRLEIIRICSDFFIK----IMKQSSKN--------------- 185

  Fly    71 RLLLPGADTGRDTYGLQITALGRLYIRVLQLPT--------------DSSDAIRLQHRNGNMYRD 121
              |:|      .|| |.|..||..|...|:|..              .|...|:|:      |:|
Yeast   186 --LIP------TTY-LFINRLGPDYEAGLELGLGENLLMKTISETCGKSMSQIKLK------YKD 235

  Fly   122 YGDVVYSVLKPRCFNP----PSNLRLKEIHQMLDTIA---NEDTEVKQQQLI-RFTEQASPEEQK 178
            .||:....:..|...|    |..|.:.|:.:.|..||   .:|:::|:.:|| |........|.|
Yeast   236 IGDLGEIAMGARNVQPTMFKPKPLTVGEVFKNLRAIAKTQGKDSQLKKMKLIKRMLTACKGIEAK 300

  Fly   179 WLIRLLLKSLGLGIGEQKIF------GVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDS 237
            :|||.|...|.:|:.|:.:.      .:||.:.::.             ..|:...:|...|...
Yeast   301 FLIRSLESKLRIGLAEKTVLISLSKALLLHDENRED-------------SPDKDVPMDVLESAQQ 352

  Fly   238 KAAVKF------------------VNLNS--VIRPFHQIRPMLCE--RFPGDIQELMQSDVLYLE 280
            |....|                  :||:.  .:||...::|||.:  :...::.:..|.:....|
Yeast   353 KIRDAFCQVPNYEIVINSCLEHGIMNLDKYCTLRPGIPLKPMLAKPTKAINEVLDRFQGETFTSE 417

  Fly   281 TKMDGERFQLH-IDRGRFMYISRNGVDYTRNFGHSYDHGTLTPKLRGLLPLGLESIILDGEMMVW 344
            .|.||||.|:| ::.|.....||||    .|....|....:|..::.|..  .:::|||.|.:.|
Yeast   418 YKYDGERAQVHLLNDGTMRIYSRNG----ENMTERYPEINITDFIQDLDT--TKNLILDCEAVAW 476

  Fly   345 DTNK----------LRFREKGENTDVKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQ 399
            |.::          .|.|:..|..|||.       :.|...:|:|.:|.:.|::.:..:|...|.
Yeast   477 DKDQGKILPFQVLSTRKRKDVELNDVKV-------KVCLFAFDILCYNDERLINKSLKERREYLT 534

  Fly   400 KLIVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAEGIVLKK-QG--SRYQPGVRLGGGWYKDK 461
            |:.....|..|........::.|..:...::::...||:::|. :|  |.|:|..| ...|.|.|
Yeast   535 KVTKVVPGEFQYATQITTNNLDELQKFLDESVNHSCEGLMVKMLEGPESHYEPSKR-SRNWLKLK 598

  Fly   462 ADYIKGLITEFDVLIIGAFYNR-KRT-FVDSFLLGVLQP--------APPGSSNRPEVFSIGVVA 516
            .||::|:....|:.::||:|.| ||| ....||||....        ...|:....|:..:
Yeast   599 KDYLEGVGDSLDLCVLGAYYGRGKRTGTYGGFLLGCYNQDTGEFETCCKIGTGFSDEMLQL---- 659

  Fly   517 NNTKQRGVLNHTLKPHWHDVVNEPPPLWFHYKPKERSGCPDLWIEPQNSVILQVKAADL------ 575
                    |:..|.|    .:.:.|...|.:   :.|..||:|.||  :.:.:|..|||
Yeast   660 --------LHDRLTP----TIIDGPKATFVF---DSSAEPDVWFEP--TTLFEVLTADLSLSPIY 707

  Fly   576 -APNGAFFTRKSLHFPRTEMKRDDK 599
             |.:..|....||.|||....|:||
Yeast   708 KAGSATFDKGVSLRFPRFLRIREDK 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	dnl1	84..613	CDD:273147	145/597 (24%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	59/232 (25%)
		BRCT	670..760	CDD:469589
		BRCT_2	830..917	CDD:465186
CDC9	NP_010117.1	dnl1	215..748	CDD:273147	137/572 (24%)