DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNAlig4 and CDC9

DIOPT Version :9

Sequence 1:	NP_572907.1	Gene:	DNAlig4 / 32322	FlyBaseID:	FBgn0030506	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_010117.1	Gene:	CDC9 / 851391	SGDID:	S000002323	Length:	755	Species:	Saccharomyces cerevisiae

Alignment Length:	675	Identity:	159/675 - (23%)
Similarity:	270/675 - (40%)	Gaps:	166/675 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ASTIKFRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGASSFYSVL 70
            :|.|.:.::|.:|.||:|   ::::.|:::...:.|.:    ..:|:..|
Yeast   143 SSNIPYSEVCEVFNKIEA---ISSRLEIIRICSDFFIK----IMKQSSKN--------------- 185

  Fly    71 RLLLPGADTGRDTYGLQITALGRLYIRVLQLPT--------------DSSDAIRLQHRNGNMYRD 121
              |:|      .|| |.|..||..|...|:|..              .|...|:|:      |:|
Yeast   186 --LIP------TTY-LFINRLGPDYEAGLELGLGENLLMKTISETCGKSMSQIKLK------YKD 235

  Fly   122 YGDVVYSVLKPRCFNP----PSNLRLKEIHQMLDTIA---NEDTEVKQQQLI-RFTEQASPEEQK 178
            .||:....:..|...|    |..|.:.|:.:.|..||   .:|:::|:.:|| |........|.|
Yeast   236 IGDLGEIAMGARNVQPTMFKPKPLTVGEVFKNLRAIAKTQGKDSQLKKMKLIKRMLTACKGIEAK 300

  Fly   179 WLIRLLLKSLGLGIGEQKIF------GVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDS 237
            :|||.|...|.:|:.|:.:.      .:||.:.::.             ..|:...:|...|...
Yeast   301 FLIRSLESKLRIGLAEKTVLISLSKALLLHDENRED-------------SPDKDVPMDVLESAQQ 352

  Fly   238 KAAVKF------------------VNLNS--VIRPFHQIRPMLCE--RFPGDIQELMQSDVLYLE 280
            |....|                  :||:.  .:||...::|||.:  :...::.:..|.:....|
Yeast   353 KIRDAFCQVPNYEIVINSCLEHGIMNLDKYCTLRPGIPLKPMLAKPTKAINEVLDRFQGETFTSE 417

  Fly   281 TKMDGERFQLH-IDRGRFMYISRNGVDYTRNFGHSYDHGTLTPKLRGLLPLGLESIILDGEMMVW 344
            .|.||||.|:| ::.|.....||||    .|....|....:|..::.|..  .:::|||.|.:.|
Yeast   418 YKYDGERAQVHLLNDGTMRIYSRNG----ENMTERYPEINITDFIQDLDT--TKNLILDCEAVAW 476

  Fly   345 DTNK----------LRFREKGENTDVKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQ 399
            |.::          .|.|:..|..|||.       :.|...:|:|.:|.:.|::.:..:|...|.
Yeast   477 DKDQGKILPFQVLSTRKRKDVELNDVKV-------KVCLFAFDILCYNDERLINKSLKERREYLT 534

  Fly   400 KLIVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAEGIVLKK-QG--SRYQPGVRLGGGWYKDK 461
            |:.....|..|........::.|..:...::::...||:::|. :|  |.|:|..| ...|.|.|
Yeast   535 KVTKVVPGEFQYATQITTNNLDELQKFLDESVNHSCEGLMVKMLEGPESHYEPSKR-SRNWLKLK 598

  Fly   462 ADYIKGLITEFDVLIIGAFYNR-KRT-FVDSFLLGVLQP--------APPGSSNRPEVFSIGVVA 516
            .||::|:....|:.::||:|.| ||| ....||||....        ...|:....|:..:
Yeast   599 KDYLEGVGDSLDLCVLGAYYGRGKRTGTYGGFLLGCYNQDTGEFETCCKIGTGFSDEMLQL---- 659

  Fly   517 NNTKQRGVLNHTLKPHWHDVVNEPPPLWFHYKPKERSGCPDLWIEPQNSVILQVKAADL------ 575
                    |:..|.|    .:.:.|...|.:   :.|..||:|.||  :.:.:|..|||
Yeast   660 --------LHDRLTP----TIIDGPKATFVF---DSSAEPDVWFEP--TTLFEVLTADLSLSPIY 707

  Fly   576 -APNGAFFTRKSLHFPRTEMKRDDK 599
             |.:..|....||.|||....|:||
Yeast   708 KAGSATFDKGVSLRFPRFLRIREDK 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	DNA_ligase_A_N	10..197	CDD:282522	49/208 (24%)
		dnl1	84..613	CDD:273147	145/597 (24%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	59/232 (25%)
		OBF_DNA_ligase_IV	469..607	CDD:153437	39/148 (26%)
		BRCT	668..745	CDD:214602
CDC9	NP_010117.1	dnl1	215..748	CDD:273147	137/572 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810