DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig4 and ATLIG4

DIOPT Version :9

Sequence 1:	NP_572907.1	Gene:	DNAlig4 / 32322	FlyBaseID:	FBgn0030506	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_568851.2	Gene:	ATLIG4 / 835822	AraportID:	AT5G57160	Length:	1219	Species:	Arabidopsis thaliana

Alignment Length:	939	Identity:	239/939 - (25%)
Similarity:	424/939 - (45%)	Gaps:	155/939 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKFRDICSLFEKIKATQKVANKEEVLKSYYESFCRHRESFRRQTGLNNDQPEDGASSFYSVLRLL 73
            |||..:.|||..|:.::..:.|....:.:.:::|:               |.|    ::..:||:
plant     5 IKFSVLVSLFNWIQKSKTSSQKRSKFRKFLDTYCK---------------PSD----YFVAVRLI 50

  Fly    74 LPGADTGRDTYGLQITALGRLYIRVLQLPTDSSDAIRLQH-RNGNMYR------DYGDVVYSVLK 131
            :|..|..|.:|||:.:.|....|..|.:..|:.||:||.: |.|...:      ::..:...||:
plant    51 IPSLDRERGSYGLKESVLATCLIDALGISRDAPDAVRLLNWRKGGTAKAGANAGNFSLIAAEVLQ 115

  Fly   132 PRCFNPPSNLRLKEIHQMLDTIA-NEDTEVKQQQLIRFTEQASPEEQKWLIRLLLKSLGLGIGEQ 195
            .|.......|.:||::.:||.:| :|:...|...|....::.:.:|.||:||::||.|.||:.|:
plant   116 RRQGMASGGLTIKELNDLLDRLASSENRAEKTLVLSTLIQKTNAQEMKWVIRIILKDLKLGMSEK 180

  Fly   196 KIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKFVNLNSVIRPFHQIRPML 260
            .||...||.|:|::....||..||..|.||.........:..||                :||.|
plant   181 SIFQEFHPDAEDLFNVTCDLKLVCEKLRDRHQRHKRQDIEVGKA----------------VRPQL 229

  Fly   261 CERFPGDI----QELMQSDVLYLETKMDGERFQLHIDRGRFMYISRNGVDYTRNFGHSYDHGTLT 321
            ..|. ||:    ::|...||: .|.|.||:|.|:|.:.....|.|||.:|::     .|.|....
plant   230 AMRI-GDVNAAWKKLHGKDVV-AECKFDGDRIQIHKNGTDIHYFSRNFLDHS-----EYAHAMSD 287

  Fly   322 PKLRGLLPLGLESIILDGEMMVWDTNKLRFREKGENTDVKSLKPEG---SWQPCFVVYDLLYFNG 383
            ..::.:|   ::..||||||:||||:..||.|.|.|.::.....||   ..|.|:|.:|:||...
plant   288 LIVQNIL---VDKCILDGEMLVWDTSLNRFAEFGSNQEIAKAAREGLDSHKQLCYVAFDVLYVGD 349

  Fly   384 QSLLDHTYIQRAYKLQKLIVEQSGVLQLMRAR----------------KIGSVQEFNELFQQALD 432
            .|::..:..:|...|:|::....|.|:::...                .:.:..:....|::.::
plant   350 TSVIHQSLKERHELLKKVVKPLKGRLEVLVPEGGLNVHRPSGEPSWSIVVHAAADVERFFKETVE 414

  Fly   433 SHAEGIVLKKQGSRYQPGVRLGGGWYKDKADYIKGLITEFDVLIIGAFY--NRKRTFVDSFLLGV 495
            :..||||||...|:::||.| .|.|.|.|.:||:. ..:.||||||.:|  .|:...|..||:.:
plant   415 NRDEGIVLKDLESKWEPGDR-SGKWMKLKPEYIRA-GADLDVLIIGGYYGSGRRGGEVAQFLVAL 477

  Fly   496 LQPAPPGSSNRPEVF----SIGVVANNTKQRGVLNHTLKPHW--HDVVNEPPPLWFHY--KPKER 552
            ...|.  ::..|..|    .:|...::.:...|:: .|||::  ::...:.||.::..  ..|||
plant   478 ADRAE--ANVYPRRFMSFCRVGTGLSDDELNTVVS-KLKPYFRKNEHPKKAPPSFYQVTNHSKER 539

  Fly   553 SGCPDLWIE-PQNSVILQVKAADLAP--NGAFFTRKSLHFPRTEMKRDDKTWSECMTLKEFNDLC 614
               ||:||: |:.|:||.: .:|:..  :..|....||.|||.:..|.||.|.||:.::.|.:|.
plant   540 ---PDVWIDSPEKSIILSI-TSDIRTIRSEVFVAPYSLRFPRIDKVRYDKPWHECLDVQAFVELV 600

  Fly   615 GGPLAI-------------KKLNKRQLRLEDVTTKRKQMRMTPSERSRLGLAVYEKRYDASTSAS 666
            ......             .|:||...|.|     :|.:.:.||:..:.         |.|....
plant   601 NSSNGTTQKQKESESTQDNPKVNKSSKRGE-----KKNVSLVPSQFIQT---------DVSDIKG 651

  Fly   667 TSKLFDGLSFCILSGSAGRHSKHQLQELAVKNGGCIVENPLPNDPKCFCIAGDETFLVKRLILQQ 731
            .:.:|..:.|..::.... ||.....::.|:|||....|  .|:....|||.:.:.:..:...:|
plant   652 KTSIFSNMIFYFVNVPRS-HSLETFHKMVVENGGKFSMN--LNNSVTHCIAAESSGIKYQAAKRQ 713

  Fly   732 PRTCDIVRMEWLLRVCQKQE-LELKPRDLIAATEPLQQDLAECFDRHGDSYTKDIANVEELQDLL 795
            .   |::...|:|..|.:.: |.|.|:..:..|:..:..|.:..|...|||..|: ::|.|:.:|
plant   714 R---DVIHFSWVLDCCSRNKMLPLLPKYFLHLTDASRTKLQDDIDEFSDSYYWDL-DLEGLKQVL 774

  Fly   796 QGIELTADNVAGITASNLNALEDQLLDGKKNLNMFRNLNAFFYSPHGDE-----------VAKLL 849
            ...:.:.|      :.:::..:.:|.. :|..:...:...:|| |:...           :||.|
plant   775 SNAKQSED------SKSIDYYKKKLCP-EKRWSCLLSCCVYFY-PYSQTLSTEEEALLGIMAKRL 831

  Fly   850 FLQ---NGGRIVDDSDPQLNLGFICMSSD 875
            .|:   .||::.::.....:|..:.|:.:
plant   832 MLEVLMAGGKVSNNLAHASHLVVLAMAEE 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig4	NP_572907.1	DNA_ligase_A_N	10..197	CDD:282522	51/194 (26%)
		dnl1	84..613	CDD:273147	167/572 (29%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	69/239 (29%)
		OBF_DNA_ligase_IV	469..607	CDD:153437	45/150 (30%)
		BRCT	668..745	CDD:214602	16/76 (21%)
ATLIG4	NP_568851.2	dnl1	61..600	CDD:273147	167/573 (29%)
		BRCT_DNA_ligase_IV_rpt1	655..741	CDD:349354	21/91 (23%)
		BRCT_DNA_ligase_IV_rpt2	802..898	CDD:349349	11/60 (18%)
		PTZ00121	<909..>1180	CDD:173412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	87	1.000	Domainoid score	I2770
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1736
Inparanoid	1	1.050	247	1.000	Inparanoid score	I1047
OMA	1	1.010	-	-		QHG54896
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	1	1.000	-	-		FOG0004767
OrthoInspector	1	1.000	-	-		oto3932
orthoMCL	1	0.900	-	-		OOG6_103257
Panther	1	1.100	-	-	LDO	PTHR45997
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3920
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840